Reconstruction of the nigrostriatal pathway by simultaneous intrastriatal and intranigral dopaminergic transplants

Journal of Neuroscience

Volumn 16, Issue 22, 1996, Pages 7216-7227

  Mendez, Ivar ^a   Sadi, Damaso ^b   Hong, Murray ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b NONE

Author keywords

dopamine; double grafts; fetal transplants; neural transplantation; nigrostriatal pathway; Parkinson's disease

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; FEMALE; FETUS CELL; NERVE TRANSPLANTATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

EID: 0029832802     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-22-07216.1996     Document Type: Article

References (37)

1. Björklund A, Stenevi U (1979) Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res 177:555-560.
2. Björklund A, Schmidt RH, Stenevi U (1980) Functional reinnervation of the neostriatum in the adult rat by use of intraparenchymal grafting from the substantia nigra. Cell Tissue Res 212:39-45.
3. Bolam JP, Freund TF, Björklund A, Dunnett SB, Smith AD (1987) Synaptic input and local output of dopaminergic neurons in grafts that functionally reinnervate the host neostriatum. Exp Brain Res 68:131-146.
4. Brecknell JE, Haque NSK, Du J-S, Muir EM, Fidler PS, Hlavin M-L, Fawcett JW, Dunnett SB (1996) Functional and anatomical reconstruction of the 6-hydroxydopamine lesioned nigrostriatal system of the adult rat. Neuroscience 71:913-925.
5. Carder RK, Snyder-Keller AM, Lund RD (1987) Amphetamine- and stress-induced turning after nigral transplants in neonatally dopamine-depleted rats. Dev Brain Res 33:315-318.
6. Clarke DJ, Brundin P, Strecker RE, Nilsson OG, Björklund A, Lindvall O (1988) Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: ultrastructure evidence for synapse formation using tyrosine hydroxylase immunocytochemistry. Exp Brain Res 73:115-126.
7. Denis-Donini S, Glowinski J, Prochiantz A (1983) Specific influence of striatal target neurons on the in vitro outgrowth of mesencephalic dopaminergic neurites: a morphological qualitative study. Neuroscience 3:2292-2299.
8. Doucet G, Murata Y, Brundin P, Bosler O, Mons N, Geffard M, Ouimet CC, Björklund A (1989) Host afferents into intrastriatal transplants of fetal ventral mesencephalon. Exp Neurol 106:1-19.
9. Dunnett SB, Björklund A (1987) Mechanisms of function of neural grafts in the adult mammalian brain. J Exp Biol 132:265-289.
10. Dunnett SB, Rogers DC, Richards S-J (1989) Nigrostriatal reconstruction after 6-ODHA lesion in rats: combination of dopamine-rich nigral grafts and nigrostriatal "bridge" grafts. Exp Brain Res 75:523-535.
11. Edelman GM, Crossin KL (1991) Cell adhesion molecules: implications for a molecular histology. Annu Rev Biochem 60:155-190.
12. Floeter MK, Jones EJ (1984) Connections made by transplants to the cerebral cortex of rat brains damaged in utero. J Neurosci 4:141-150.
13. Forni C, Brundin P, Stricker EM, El Ganouni S, Björklund A, Nieoullon A (1989) Time-course of recovery of dopamine neuron activity during reinnervation of the denervated striatum by fetal mesencephalic grafts as assessed by in vivo voltammetry. Exp Brain Res 76:75-87.
14. Freund TF, Bolam JP, Björklund A, Stenevi U, Dunnett SB, Powell JF, Smith AD (1985) Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: a tyrosine hydroxylase immunocytochemical study. J Neurosci 5:603-616.
15. Herman JP, Choulli K, Le Moal M (1985) Hyper-reactivity to amphetamine in rats with dopaminergic grafts. Exp Brain Res 60:521-526.
16. Herman JP, Abrous DN, Le MM (1991) Anatomical and behavioral comparison of unilateral dopamine-rich grafts implanted into the striatum of neonatal and adult rats. Neuroscience 40:465-475.
17. Lund RD, Radel JD, Hankin MH, Klassen H, Coffey PJ, Rawlins JNP (1990) Developmental and functional integrations of retinal transplants with host rat brains. In: Brain repair (Björklund A, Aguayo AJ, Ottoson D, eds), pp 327-340. London: McMillan.
18. McKeon RJ, Schreiber RC, Rudge JS, Silver J (1991) Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with expression of inhibitory molecules on reactive astrocytes. J Neurosci 11:3398-3411.
19. Mendez I, Elisevich K, Flumerfelt B (1991) Dopaminergic innervation of substance P-containing striatal neurons by fetal nigral grafts: an ultrastructural double-labeling immunocytochemical study. J Comp Neurol 308:66-78.
20. Nikkhah G, Bentlage C, Cunningham MG, Björklund A (1994a) Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model. J Neurosci 14:3449-3461.
21. Nikkhah G, Cunningham MG, Jödicke A, Knappe U, Björklund A (1994b) Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model. Brain Res 633:133-143.
22. Nikkhah G, Olsson M, Eberhard J, Bentlage C, Cunningham MG, Björklund A (1994c) A microtransplantation approach for cell suspension grafting in the rat Parkinson model: a detailed account of the methodology. Neurology 63:57-72.
23. Nikkhah G, Cunningham MG, Cenci MA, McKay RD, Björklund A (1995a) Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. I. Evidence for anatomical reconstruction of the nigrostriatal pathway. J Neurosci 15:3548-3561.
24. Nikkhah G, Cunningham MG, McKay R, Björklund A (1995b) Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery. J Neurosci 15:3562-3570.
25. Olsson M, Nikkhah G, Bentlage C, Björklund A (1995) Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15:3863-3875.
26. Prochiantz A, DiPorzio U, Kato A, Berger B, Glowinski J (1979) In vitro maturation of mesencephalic dopaminergic neurons from mouse embryos is enhanced in presence of their striatal target cells. Proc Natl Acad Sci USA 76:5387-5391.
27. Schnell L, Schwab ME (1990) Axonal regeneration in the rat spinal cord produced an antibody against myelin-associated neurite growth inhibitors. Nature 343:269-272.
28. Schwab ME (1990) Myelin-associated inhibitors of neurite growth and regeneration in the CNS. Trends Neurosci 13:452-455.
29. Schwab ME, Kapfhammer JP, Bandtlow CE (1993) Inhibitors of neurite growth. Annu Rev Neurosci 16:565-595.
30. Snyder-Keller AM, Carder RK, Lund RD (1989) Development of dopamine innervation and turning behavior in dopamine-depleted infant rats receiving unilateral nigral transplants. Neuroscience 30:779-794.
31. Stanfield BB, O'Leary DDM (1985) Fetal occipital cortical neurones transplanted to the rostral cortex can extend and maintain a pyramidal tract axon. Nature 313:135-137.
32. Takeichi M (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251:1451-1455.
33. Wictorin K, Ouimet CC, Björklund A (1989a) Intrinsic organization and connectivity of intrastriatal striatal transplants in rats as revealed by DARPP-32 immunohistochemistry: specificity of connections with the lesioned host brain. Eur J Neurosci 1:690-701.
34. Wictorin K, Simberly RB, Isacson O, Swanson LW, Björklund A (1989b) Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum. III. Efferent projecting graft neurons and their relation to host afferents within the grafts. Neuroscience 30:313-330.
35. Wictorin K, Brundin P, Gustavii B, Lindvall O, Björklund A (1990) Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts. Nature 347:556-558.
36. Wictorin K, Brundin P, Sauer H, Lindvall O, Björklund A (1992) Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats. J Comp Neurol 323:475-494.
37. Zhou FC, Chiang YH (1995) Excitochemical-induced trophic bridging directs axonal growth of transplanted neurons to distal target. Cell Transplant 4:103-112.