Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 4, 2007, Pages

  Morrison, R Ray ^a   Tan, Xing Lin ^b   Ledent, Catherine ^c   Mustafa, S Jamal ^d   Hofmann, Polly A ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac troponin I; Ischemia reperfusion; Phosphorylated Akt; Phosphorylated extracellular signal regulated kinase 1 2

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; RECEPTOR SUBTYPE; SYNAPSIN I; MITOGEN ACTIVATED PROTEIN KINASE 3; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; TROPONIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; ENZYME PHOSPHORYLATION; GENE DELETION; GENE TARGETING; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISOLATED HEART; KNOCKOUT MOUSE; MOUSE; MYOCARDIAL POSTCONDITIONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RECEPTOR GENE; RECEPTOR UPREGULATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART VENTRICLE PRESSURE; METABOLISM; METHODOLOGY; MOUSE MUTANT; PATHOPHYSIOLOGY; PHOSPHORYLATION; TIME;

ADENOSINE; ANIMALS; DISEASE MODELS, ANIMAL; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ADENOSINE A2A; RESEARCH DESIGN; SIGNAL TRANSDUCTION; TIME FACTORS; TRIAZINES; TRIAZOLES; TROPONIN I; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 35349031091     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00612.2007     Document Type: Article

References (40)

1. Ashton KJ, Peart JN, Morrison RR, Matherne GP, Blackburn MR, Headrick JP. Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues. J Mol Cell Cardiol 42: 693-705, 2007.
2. Bopassa JC, Ferrera R, Gateau-Roesch O, Couture-Lepetit E, Ovize M. PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning. Cardiovasc Res 69: 178-185, 2006.
3. 2A adenosine receptors: dependent of phosphatidylinositol 3-kinase pathway. J Cardiovasc Pharmacol 43: 416-422, 2004.
4. 2A adenosine receptor stimulation after 72 hours of myocardial reperfusion. J Cardiovasc Pharmacol 45: 439-446, 2005.
5. Darling CE, Jiang R, Maynard M, Whittaker P, Vinten-Johansen J, Przyklenk K. Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2. Am J Physiol Heart Circ Physiol 289: H1618-H1626, 2005.
6. Eckle T, Grenz A, Kohler D, Redel A, Falk M, Rolauffs B, Osswald H, Kehl F, Eltzschig HK. Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice. Am J Physiol Heart Circ Physiol 291: H2533-H2540, 2006.
7. Germack R, Dickenson JM. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol 141: 329-339, 2004.
8. Gross ER, Gross GJ. Ligand triggers of classical preconditioning and postconditioning. Cardiovasc Res 70: 212-221, 2006.
9. Gross GJ, Auchampach JA. Reperfusion injury: does it exist? J Mol Cell Cardiol 42: 12-18, 2007.
10. Hausenloy DJ, Tsang A, Yellon DM. The reperfusion injury survival kinase pathway: a common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc Med 15: 69-75, 2005.
11. Hausenloy DJ, Yellon DM. Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res 70: 240-253, 2006.
12. Headrick JP, Hack B, Ashton KJ. Acute adenosinergic cardioprotection in ischemic-reperfused hearts. Am J Physiol Heart Circ Physiol 285: H1797-H1818, 2003.
13. Kaljusto ML, Mori T, Rizvi SMH, Galagudza M, Frantzen ML, Valen G, Vaage J. Postconditioning in rats and mice. Scand Cardiovasc J 40: 334-341, 2006.
14. Kin H, Zatta AJ, Lofye MT, Amerson BS, Halkos ME, Kerendi F, Zhao ZQ, Guyton RA, Headrick JP, Vinten-Johansen J. Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine. Cardiovasc Res 67: 124-133, 2005.
15. Kloner RA, Rezkalla SH. Preconditioning, postconditioning and their application to clinical cardiology. Cardiovasc Res 70: 297-307, 2006.
16. 2A receptor. Nature 388: 674-678, 1997.
17. 2B receptors. Am J Physiol Heart Circ Physiol 282: H437-H444, 2002.
18. 1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes. Am J Physiol Heart Circ Physiol 291: H1875-H1882, 2006.
19. Murry CE, Jenning RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124-1136, 1986.
20. Peart JN, Headrick JP. Adenosinergic cardioprotection: multiple receptors, multiple pathways. Pharmacol Ther 114: 208-221 2007.
21. Penna C, Cappello S, Mancardi D, Raimondo S, Rastaldo R, Gattullo D, Losano G, Pagliaro P. Post-conditioning reduces infarct size in the isolated rat heart: role of coronary flow and pressure and the nitric oxide/cGMP pathway. Basic Res Cardiol 101: 168-179, 2006.
22. 2B receptor cascade. Cardiovasc Res 70: 308-314, 2006.
23. 2A selective adenosine receptor antagonist. Br J Pharmacol 115: 1096-1102, 1995.
24. Reid EA, Kristo G, Yoshimura Y, Ballard-Croft C, Keith BJ, Mentzer RM, Lasley RD. In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling. Am J Physiol Heart Circ Physiol 288: H2253-H2259, 2005.
25. 2B receptor recruits divergent pathways to regulate ERK1/2 and p38. Exp Cell Res 290: 168-176, 2003.
26. Schwartz LM, Lagranha CJ. Ischemic postconditioning during reperfusion activates Akt and ERK without protecting against lethal myocardial ischemia-reperfusion injury in pigs. Am J Physiol Heart Circ Physiol 290: H1011-H1018, 2006.
27. Solenkova NV, Solodushko V, Cohen MV, Downey JM. Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. Am J Physiol Heart Circ Physiol 290: H441-H449, 2006.
28. Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit JF, Bonnefoy E, Finet G, Andre-Fouet X, Ovize M. Postconditioning the human heart. Circulation 112: 2143-2148, 2005.
29. 3 receptors augments adenosine-induced coronary flow in isolated mouse hearts. Am J Physiol Heart Circ Physiol 282: H2183-H2189, 2002.
30. 2B Receptors in Mice. J Cardiovasc Pharmacol 41: 562-570, 2003.
31. Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM. Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res 95: 230-232, 2004.
32. Vinten-Johansen J, Thourani VH, Ronson RS, Jordan JE, Zhao ZQ, Nakamura M, Velez D, Guyton RA. Broad spectrum cardioprotection with adenosine. Ann Thorac Surg 68: 1942-1948, 1999.
33. Vinten-Johansen J, Zhao ZQ, Zatta A, Kin H, Halkos ME, Kerendi F. Postconditioning: a new link in nature's armor against myocardial ischemia-reperfusion injury. Basic Res Cardiol 100: 295-310, 2005.
34. 2 receptor activation at reperfusion. J Cardiovasc Pharmacol 46: 794-802, 2005.
35. Yang XM, Philipp S, Downey JM, Cohen MV. Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and quanylyl cyclase activation. Basic Res Cardiol 100: 57-63, 2005.
36. Yang XM, Proctor JB, Cui L, Krieg T, Downey JM, Cohen MV. Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol 44: 1103-1110, 2004.
37. + T lymphocytes. Circulation 114: 2056-2064, 2006.
38. Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Vinten-Johansen J. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 285: H579-H588, 2003.
39. Zhao ZQ, Vinten-Johansen J. Postconditioning: reduction of reperfusion-induced injury. Cardiovasc Res 70: 200-211, 2006.
40. Zhu M, Feng J, Lucchinetti E, Fischer G, Xu L, Pedrazzini T, Schaub MC, Zaugg M. Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc Res 72: 152-162, 2006.