Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(a-azolylbenzyl)-1H-indoles as selective aromatase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 22, Issue 5, 2007, Pages 667-676

  Le Borgne, Marc ^a   Marchand, Pascal ^a   Nourrisson, Marie Renee ^a   Loquet, Denis ^a   Palzer, Martina ^b   Baut, Guillaume Le ^a   Hartmann, Rolf W ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

17 hydroxylase C17,20 lyase; Aromatase; Azoles; Breast cancer; Indole; Inhibitor; Selective

Indexed keywords

1 (2 CHLOROBENZYL) 1H 3 INDOLECARBALDEHYDE; 1 (2 CHLOROBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 1 (2 CHLOROBENZYL) 3 HYDROXYMETHYL 1H INDOLE; 1 (2 FLUOBENZYL) 3 (1H IMIDAZOL 1 YLMETHYL) 1H INDOLE; 1 (2 FLUOROBENZYL) 1H 3 INDOLECARBALDEHYDE; 1 (2 FLUOROBENZYL) 3 HYDROXYMETHYL 1H INDOLE; 1 (3 FLUOROBENZYL) 1H 3 INDOLECARBALDEHYDE; 1 (3 FLUOROBENZYL) 3 HYDROXYMETHYL 1H INDOLE; 1 (4 CYANOBENZYL) 1H 3 INDOLECARBALDEHYDE; 1 (4 CYANOBENZYL) 3 HYDROXYMETHYL 1H INDOLE; 3 (ALPHA AZOLYLBENZYL) 1H INDOLE DERIVATIVE; 3 (AZOLYLMETHYL) 1H INDOLE DERIVATIVE; 4 [N (4 BROMOBENZYL) N (1,2,4 TRIAZOL 4 YL)AMINO]BENZONITRILE; 5 BROMO 1 (2 CHLOROBENZYL) 3 (4 FLUOROBENZOYL) 1H INDOLE; 5 BROMO 1 (2 CHLOROBENZYL) 3 [(4 FLUOROPHENYL)(HYDROXY)METHYL] 1H INDOLE; 5 BROMO 1 ETHYL 3 (4 FLUOROBENZOYL) 1H INDOLE; 5 BROMO 1 ETHYL 3 [(4 FLUOROPHENYL)(HYDROXY)METHYL] 1H INDOLE; 5 BROMO 3 (2,4 DICHLOROBENZOYL) 1 ETHYL 1H INDOLE; 5 BROMO 3 (4 FLUOROBENZOYL) 1 (4 FLUOROBENZOYL) 1H INDOLE; 5 BROMO 3 (4 FLUOROBENZOYL) 1H INDOLE; 5 BROMO 3 [(2,4 DICHLOROPHENYL)(HYDROXY)METHYL] 1 ETHYL 1H INDOLE; AMINOGLUTETHIMIDE; ANASTROZOLE; ANTINEOPLASTIC AGENT; AROMATASE; AROMATASE INHIBITOR; FADROZOLE; LETROZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOROZOLE;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AROMATASE INHIBITORS; AZOLES; ENZYME ACTIVATION; FEMALE; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MALE; MICROSOMES; MOLECULAR STRUCTURE; PLACENTA; RATS; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS;

EID: 35349009106     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360701652658     Document Type: Article

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