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Volumn 66, Issue 5, 2007, Pages 529-537

Human soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN; LYMPHOCYTE ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; RECOMBINANT PROTEIN; RECOMBINANT SOLUBLE CD80; UNCLASSIFIED DRUG;

EID: 35348940179     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2007.02009.x     Document Type: Article
Times cited : (32)

References (51)
  • 1
    • 0036669785 scopus 로고    scopus 로고
    • The interaction properties of costimulatory molecules revisited
    • Collins AV, Brodie DW, Gilbert RJ et al. The interaction properties of costimulatory molecules revisited. Immunity 2002 17 : 201 10.
    • (2002) Immunity , vol.17 , pp. 201-10
    • Collins, A.V.1    Brodie, D.W.2    Gilbert, R.J.3
  • 2
    • 0029856894 scopus 로고    scopus 로고
    • Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes
    • Fleischer J, Soeth E, Reiling N, Grage-Griebenow E, Flad HD, Ernst M. Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes. Immunology 1996 89 : 592 8.
    • (1996) Immunology , vol.89 , pp. 592-8
    • Fleischer, J.1    Soeth, E.2    Reiling, N.3    Grage-Griebenow, E.4    Flad, H.D.5    Ernst, M.6
  • 3
    • 0032706715 scopus 로고    scopus 로고
    • Peripheral blood antigen-presenting cells from African-Americans exhibit increased CD80 and CD86 expression
    • Hutchings A, Purcell WM, Benfield MR. Peripheral blood antigen-presenting cells from African-Americans exhibit increased CD80 and CD86 expression. Clin Exp Immunol 1999 118 : 247 52.
    • (1999) Clin Exp Immunol , vol.118 , pp. 247-52
    • Hutchings, A.1    Purcell, W.M.2    Benfield, M.R.3
  • 4
    • 0024444165 scopus 로고
    • B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
    • Freeman GJ, Freedman AS, Segil JM, Lee G, Whitman JF, Nadler LM. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol 1989 143 : 2714 22.
    • (1989) J Immunol , vol.143 , pp. 2714-22
    • Freeman, G.J.1    Freedman, A.S.2    Segil, J.M.3    Lee, G.4    Whitman, J.F.5    Nadler, L.M.6
  • 5
    • 0037330704 scopus 로고    scopus 로고
    • CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties
    • Vasu C, Wang A, Gorla SR, Kaithamana S, Prabhakar BS, Holterman MJ. CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties. Int Immunol 2003 15 : 167 75.
    • (2003) Int Immunol , vol.15 , pp. 167-75
    • Vasu, C.1    Wang, A.2    Gorla, S.R.3    Kaithamana, S.4    Prabhakar, B.S.5    Holterman, M.J.6
  • 6
    • 0029133256 scopus 로고
    • Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28
    • Peach RJ, Bajorath J, Naemura J et al. Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. J Biol Chem 1995 270 : 21181 7.
    • (1995) J Biol Chem , vol.270 , pp. 21181-7
    • Peach, R.J.1    Bajorath, J.2    Naemura, J.3
  • 7
    • 0032761161 scopus 로고    scopus 로고
    • New forms of dog CD80 and CD86 transcripts that encode secreted B7 molecules
    • Yang S, Sim GK. New forms of dog CD80 and CD86 transcripts that encode secreted B7 molecules. Immunogenetics 1999 50 : 349 53.
    • (1999) Immunogenetics , vol.50 , pp. 349-53
    • Yang, S.1    Sim, G.K.2
  • 9
    • 0028925551 scopus 로고
    • Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain
    • Guo Y, Wu Y, Zhao M, Kong XP, Liu Y. Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain. J Exp Med 1995 181 : 1345 55.
    • (1995) J Exp Med , vol.181 , pp. 1345-55
    • Guo, Y.1    Wu, Y.2    Zhao, M.3    Kong, X.P.4    Liu, Y.5
  • 11
    • 0034659768 scopus 로고    scopus 로고
    • Primary structure and functional characterization of a soluble, alternatively spliced form of B7-1
    • Faas SJ, Giannoni MA, Mickle AP et al. Primary structure and functional characterization of a soluble, alternatively spliced form of B7-1. J Immunol 2000 164 : 6340 8.
    • (2000) J Immunol , vol.164 , pp. 6340-8
    • Faas, S.J.1    Giannoni, M.A.2    Mickle, A.P.3
  • 12
    • 4544269839 scopus 로고    scopus 로고
    • Identification of a circulating soluble form of CD80: Levels in patients with hematological malignancies
    • Hock B, Starling G, Patton W et al. Identification of a circulating soluble form of CD80: levels in patients with hematological malignancies. Leuk Lymphoma 2004 45 : 2111 8.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2111-8
    • Hock, B.1    Starling, G.2    Patton, W.3
  • 13
    • 24944465752 scopus 로고    scopus 로고
    • Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus
    • Wong CK, Lit LC, Tam LS, Li EK, Lam CW. Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus. Rheumatology (Oxford) 2005 44 : 989 94.
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 989-94
    • Wong, C.K.1    Lit, L.C.2    Tam, L.S.3    Li, E.K.4    Lam, C.W.5
  • 14
    • 19444366800 scopus 로고    scopus 로고
    • Elevation of plasma soluble T cell costimulatory molecules CTLA-4, CD28 and CD80 in children with allergic asthma
    • Ip WK, Wong CK, Leung TF, Lam CW. Elevation of plasma soluble T cell costimulatory molecules CTLA-4, CD28 and CD80 in children with allergic asthma. Int Arch Allergy Immunol 2005 137 : 45 52.
    • (2005) Int Arch Allergy Immunol , vol.137 , pp. 45-52
    • Ip, W.K.1    Wong, C.K.2    Leung, T.F.3    Lam, C.W.4
  • 15
    • 35348953066 scopus 로고
    • CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production
    • Freeman GJ, Lombard DB, Gimmi CD et al. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J Immunol 1992 15 : 149.
    • (1992) J Immunol , vol.15 , pp. 149
    • Freeman, G.J.1    Lombard, D.B.2    Gimmi, C.D.3
  • 16
    • 35348970795 scopus 로고    scopus 로고
    • The clinical significance of soluble CD86 levels in patients with acute myeloid leukemia and myelodysplastic syndrome
    • Hock BD, McKenzie JL, Patton WN et al. The clinical significance of soluble CD86 levels in patients with acute myeloid leukemia and myelodysplastic syndrome. Cancer 2003 15 : 98.
    • (2003) Cancer , vol.15 , pp. 98
    • Hock, B.D.1    McKenzie, J.L.2    Patton, W.N.3
  • 17
    • 0036099578 scopus 로고    scopus 로고
    • Human plasma contains a soluble form of CD86 which is present at elevated levels in some leukaemia patients
    • Hock BD, Patton WN, Budhia S, Mannari D, Roberts P, McKenzie JL. Human plasma contains a soluble form of CD86 which is present at elevated levels in some leukaemia patients. Leukemia 2002 16 : 865 73.
    • (2002) Leukemia , vol.16 , pp. 865-73
    • Hock, B.D.1    Patton, W.N.2    Budhia, S.3    Mannari, D.4    Roberts, P.5    McKenzie, J.L.6
  • 18
    • 6344238673 scopus 로고    scopus 로고
    • Soluble CD86 protein in serum samples of patients with asthma
    • Shi HZ, Xie ZF, Deng JM, Chen YQ, Xiao CQ. Soluble CD86 protein in serum samples of patients with asthma. Thorax 2004 59 : 870 5.
    • (2004) Thorax , vol.59 , pp. 870-5
    • Shi, H.Z.1    Xie, Z.F.2    Deng, J.M.3    Chen, Y.Q.4    Xiao, C.Q.5
  • 19
    • 2142705256 scopus 로고    scopus 로고
    • Detection of circulating soluble CD28 in patients with systemic lupus erythematosus, primary Sjogren's syndrome and systemic sclerosis
    • Hebbar M, Jeannin P, Magistrelli G et al. Detection of circulating soluble CD28 in patients with systemic lupus erythematosus, primary Sjogren's syndrome and systemic sclerosis. Clin Exp Immunol 2004 136 : 388 92.
    • (2004) Clin Exp Immunol , vol.136 , pp. 388-92
    • Hebbar, M.1    Jeannin, P.2    Magistrelli, G.3
  • 20
    • 0036710498 scopus 로고    scopus 로고
    • Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: Effect of an AT-rich gene sequence
    • Wang XB, Kakoulidou M, Giscombe R et al. Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence. J Neuroimmunol 2002 130 : 224 32.
    • (2002) J Neuroimmunol , vol.130 , pp. 224-32
    • Wang, X.B.1    Kakoulidou, M.2    Giscombe, R.3
  • 21
    • 35348990174 scopus 로고    scopus 로고
    • Cutting edge: A soluble form of CTLA-4 in patients with autoimmune thyroid disease
    • Oaks MK, Hallett KM. Cutting edge: a soluble form of CTLA-4 in patients with autoimmune thyroid disease. J Immunol 2000 15 : 164.
    • (2000) J Immunol , vol.15 , pp. 164
    • Oaks, M.K.1    Hallett, K.M.2
  • 22
    • 5444243792 scopus 로고    scopus 로고
    • Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis
    • Sato S, Fujimoto M, Hasegawa M et al. Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis. Rheumatology (Oxford) 2004 43 : 1261 6.
    • (2004) Rheumatology (Oxford) , vol.43 , pp. 1261-6
    • Sato, S.1    Fujimoto, M.2    Hasegawa, M.3
  • 23
    • 0038040546 scopus 로고    scopus 로고
    • Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus
    • Liu MF, Wang CR, Chen PC, Fung LL. Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus. Scand J Immunol 2003 57 : 568 72.
    • (2003) Scand J Immunol , vol.57 , pp. 568-72
    • Liu, M.F.1    Wang, C.R.2    Chen, P.C.3    Fung, L.L.4
  • 24
    • 4544269839 scopus 로고    scopus 로고
    • Identification of a circulating soluble form of CD80: Levels in patients with hematological malignancies
    • Hock BD, Starling GC, Patton WN et al. Identification of a circulating soluble form of CD80: levels in patients with hematological malignancies. Leuk Lymphoma 2004 45 : 2111 8.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2111-8
    • Hock, B.D.1    Starling, G.C.2    Patton, W.N.3
  • 25
    • 0015387315 scopus 로고
    • Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides
    • Andersson J, Sjoberg O, Moller G. Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides. Eur J Immunol 1972 2 : 349 53.
    • (1972) Eur J Immunol , vol.2 , pp. 349-53
    • Andersson, J.1    Sjoberg, O.2    Moller, G.3
  • 26
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: An overview of signals, mechanisms and functions
    • Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004 75 : 163 89.
    • (2004) J Leukoc Biol , vol.75 , pp. 163-89
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 27
    • 0035133292 scopus 로고    scopus 로고
    • Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses
    • Bugeon L, Hargreaves RE, Crompton T et al. Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses. Eur J Immunol 2001 31 : 118 27.
    • (2001) Eur J Immunol , vol.31 , pp. 118-27
    • Bugeon, L.1    Hargreaves, R.E.2    Crompton, T.3
  • 28
    • 0019409654 scopus 로고
    • The use of concanavalin a to study the immunoregulation of human T cells
    • Dwyer JM, Johnson C. The use of concanavalin A to study the immunoregulation of human T cells. Clin Exp Immunol 1981 46 : 237 49.
    • (1981) Clin Exp Immunol , vol.46 , pp. 237-49
    • Dwyer, J.M.1    Johnson, C.2
  • 29
    • 1542328827 scopus 로고    scopus 로고
    • B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis: A model for lentivirus-induced T cell depletion
    • Vahlenkamp TW, Bull ME, Dow JL et al. B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion. Vet Immunol Immunopathol 2004 98 : 203 14.
    • (2004) Vet Immunol Immunopathol , vol.98 , pp. 203-14
    • Vahlenkamp, T.W.1    Bull, M.E.2    Dow, J.L.3
  • 30
    • 0032935966 scopus 로고    scopus 로고
    • Expression of CD80 and CD86 on peripheral blood T lymphocytes in patients with systemic lupus erythematosus
    • Abe K, Takasaki Y, Ushiyama C et al. Expression of CD80 and CD86 on peripheral blood T lymphocytes in patients with systemic lupus erythematosus. J Clin Immunol 1999 19 : 58 66.
    • (1999) J Clin Immunol , vol.19 , pp. 58-66
    • Abe, K.1    Takasaki, Y.2    Ushiyama, C.3
  • 31
    • 0032974046 scopus 로고    scopus 로고
    • CD80 and CD86 costimulatory molecules on circulating T cells of HIV infected individuals
    • Kochli C, Wendland T, Frutig K, Grunow R, Merlin S, Pichler WJ. CD80 and CD86 costimulatory molecules on circulating T cells of HIV infected individuals. Immunol Lett 1999 65 : 197 201.
    • (1999) Immunol Lett , vol.65 , pp. 197-201
    • Kochli, C.1    Wendland, T.2    Frutig, K.3    Grunow, R.4    Merlin, S.5    Pichler, W.J.6
  • 33
    • 0035865391 scopus 로고    scopus 로고
    • Acquisition of CD80 (B7-1) by T cells
    • Sabzevari H, Kantor J, Jaigirdar A et al. Acquisition of CD80 (B7-1) by T cells. J Immunol 2001 166 : 2505 13.
    • (2001) J Immunol , vol.166 , pp. 2505-13
    • Sabzevari, H.1    Kantor, J.2    Jaigirdar, A.3
  • 34
    • 35348979069 scopus 로고    scopus 로고
    • Acquisition of CD80 by human T cells at early stages of activation: Functional involvement of CD80 acquisition in T cell to T cell interaction
    • Tatari-Calderone Z, Semnani RT, Nutman TB, Schlom J, Sabzevari H. Acquisition of CD80 by human T cells at early stages of activation: functional involvement of CD80 acquisition in T cell to T cell interaction. J Immunol 2002 1 : 169.
    • (2002) J Immunol , vol.1 , pp. 169
    • Tatari-Calderone, Z.1    Semnani, R.T.2    Nutman, T.B.3    Schlom, J.4    Sabzevari, H.5
  • 35
    • 35348975970 scopus 로고    scopus 로고
    • B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]
    • Taylor PA, Lees CJ, Fournier S, Allison JP, Sharpe AH, Blazar BR. B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]. J Immunol 2004 1 : 172.
    • (2004) J Immunol , vol.1 , pp. 172
    • Taylor, P.A.1    Lees, C.J.2    Fournier, S.3    Allison, J.P.4    Sharpe, A.H.5    Blazar, B.R.6
  • 36
    • 0029089750 scopus 로고
    • Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4
    • Fargeas CA, Truneh A, Reddy M, Hurle M, Sweet R, Sekaly RP. Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J Exp Med 1995 1 : 182.
    • (1995) J Exp Med , vol.1 , pp. 182
    • Fargeas, C.A.1    Truneh, A.2    Reddy, M.3    Hurle, M.4    Sweet, R.5    Sekaly, R.P.6
  • 38
    • 0032577644 scopus 로고    scopus 로고
    • Non-glycosylated human B7-1(CD80) retains the capacity to bind its counter-receptors
    • Chen A, Meyerson HJ, Salvekar A, Tykocinski ML. Non-glycosylated human B7-1(CD80) retains the capacity to bind its counter-receptors. FEBS Lett 1998 29 : 428.
    • (1998) FEBS Lett , vol.29 , pp. 428
    • Chen, A.1    Meyerson, H.J.2    Salvekar, A.3    Tykocinski, M.L.4
  • 40
    • 0036141947 scopus 로고    scopus 로고
    • A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes
    • Deshpande M, Venuprasad K, Parab PB, Saha B, Mitra D. A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes. Hum Immunol 2002 63 : 20 3.
    • (2002) Hum Immunol , vol.63 , pp. 20-3
    • Deshpande, M.1    Venuprasad, K.2    Parab, P.B.3    Saha, B.4    Mitra, D.5
  • 41
    • 0033169022 scopus 로고    scopus 로고
    • Expression of a variant of CD28 on a subpopulation of human NK cells: Implications for B7-mediated stimulation of NK cells
    • Galea-Lauri J, Darling D, Gan SU et al. Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells. J Immunol 1999 1 : 163.
    • (1999) J Immunol , vol.1 , pp. 163
    • Galea-Lauri, J.1    Darling, D.2    Gan, S.U.3
  • 42
    • 0043237868 scopus 로고    scopus 로고
    • CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease
    • Deurloo DT, van Berkel MA, van Esch BC et al. CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease. Clin Exp Allergy 2003 33 : 1297 304.
    • (2003) Clin Exp Allergy , vol.33 , pp. 1297-304
    • Deurloo, D.T.1    Van Berkel, M.A.2    Van Esch, B.C.3
  • 43
    • 0035057078 scopus 로고    scopus 로고
    • B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
    • Mandelbrot DA, Oosterwegel MA, Shimizu K et al. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest 2001 107 : 881 7.
    • (2001) J Clin Invest , vol.107 , pp. 881-7
    • Mandelbrot, D.A.1    Oosterwegel, M.A.2    Shimizu, K.3
  • 45
    • 35348983324 scopus 로고    scopus 로고
    • Costimulation light: Activation of CD4+ T cells with CD80 or CD86 rather than anti-CD28 leads to a Th2 cytokine profile
    • Broeren CP, Gray GS, Carreno BM, June CH. Costimulation light: activation of CD4+ T cells with CD80 or CD86 rather than anti-CD28 leads to a Th2 cytokine profile. J Immunol 2000 15 : 165.
    • (2000) J Immunol , vol.15 , pp. 165
    • Broeren, C.P.1    Gray, G.S.2    Carreno, B.M.3    June, C.H.4
  • 46
    • 0034256398 scopus 로고    scopus 로고
    • Bacterially produced human B7-1 protein encompassing its complete extracellular domain maintains its costimulatory activity in vitro
    • Shen W, Wang Y, Geng Y, Si L. Bacterially produced human B7-1 protein encompassing its complete extracellular domain maintains its costimulatory activity in vitro. Chin Med J (Engl) 2000 113 : 714 9.
    • (2000) Chin Med J (Engl) , vol.113 , pp. 714-9
    • Shen, W.1    Wang, Y.2    Geng, Y.3    Si, L.4
  • 47
    • 35348965595 scopus 로고    scopus 로고
    • Potent activity of soluble B7-IgG fusion proteins in therapy of established tumors and as vaccine adjuvant
    • Sturmhoefel K, Lee K, Gray GS et al. Potent activity of soluble B7-IgG fusion proteins in therapy of established tumors and as vaccine adjuvant. Cancer Res 1999 1 : 59.
    • (1999) Cancer Res , vol.1 , pp. 59
    • Sturmhoefel, K.1    Lee, K.2    Gray, G.S.3
  • 48
    • 0036935086 scopus 로고    scopus 로고
    • Soluble tumor necrosis factor receptor type II in the early diagnosis of fever in neutropenia
    • Goetz M, Behre G, Heussel G et al. Soluble tumor necrosis factor receptor type II in the early diagnosis of fever in neutropenia. Ann Hematol 2002 81 : 382 5.
    • (2002) Ann Hematol , vol.81 , pp. 382-5
    • Goetz, M.1    Behre, G.2    Heussel, G.3
  • 49
    • 0036330146 scopus 로고    scopus 로고
    • Soluble FLT-1 is detectable in the sera of colorectal and breast cancer patients
    • Kumar H, Heer K, Greenman J, Kerin MJ, Monson JR. Soluble FLT-1 is detectable in the sera of colorectal and breast cancer patients. Anticancer Res 2002 22 : 1877 80.
    • (2002) Anticancer Res , vol.22 , pp. 1877-80
    • Kumar, H.1    Heer, K.2    Greenman, J.3    Kerin, M.J.4    Monson, J.R.5
  • 50
  • 51
    • 3543112656 scopus 로고    scopus 로고
    • Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83
    • Zinser E, Lechmann M, Golka A, Lutz MB, Steinkasserer A. Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83. J Exp Med 2004 2 : 200.
    • (2004) J Exp Med , vol.2 , pp. 200
    • Zinser, E.1    Lechmann, M.2    Golka, A.3    Lutz, M.B.4    Steinkasserer, A.5


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