Active micromixer based on artificial cilia

Physics of Fluids

Volumn 19, Issue 8, 2007, Pages

  Khatavkar, Vinayak V ^a   Anderson, Patrick D ^a   den Toonder, Jaap M J ^a   Meijer, Han E H ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL METHODS; COMPUTER SIMULATION; FLOW PATTERNS; FLUID STRUCTURE INTERACTION; MATHEMATICAL MODELS; MICROACTUATORS; MICROCHANNELS; MIXERS (MACHINERY);

ACTIVE MICROMIXER; ARTIFICIAL CILIA; SIMULATED FLOW PATTERNS;

MIXING;

COMPUTATIONAL METHODS; COMPUTER SIMULATION; FLOW PATTERNS; FLUID STRUCTURE INTERACTION; MATHEMATICAL MODELS; MICROACTUATORS; MICROCHANNELS; MIXERS (MACHINERY); MIXING;

EID: 35348923771     PISSN: 10706631     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.2762206     Document Type: Article

References (47)

1. M. A. Burns, B. N. Johnson, S. N. Brahmasandra, K. Handique, J. R. Websters, M. Krishnan, T. S. Sammarco, P. M. Man, D. Jones, D. Heldsinger, C. H. Mastrangelo, and D. T. Burke, "An integrated nanoliter DNA analysis device," Science SCIEAS0036-807510.1126/ science.282.5388.484 282, 484 (1998).
2. M. W. Losey, M. A. Schmidt, and K. F. Jensen, "Microfabricated multiphase packed-bed reactors: Characterization of mass transfer and reactions," Ind. Eng. Chem. Res. IECRED0888-588510.1021/ie000523f 40, 2555 (2001).
3. P. K. Yuen, L. J. Kricka, P. Fortina, N. J. Panaro, T. Sakazume, and P. Wilding, "Microchip module for blood sample preparation and nucleic acid amplification reactions," Genome Res. GEREFS1088-905110.1101/ gr.155301 11, 405 (2001).
4. D. J. Beebe, G. A. Mensing, and G. M. Walker, "Physics and applications of microfluidics in biology," Annu. Rev. Biomed. Eng. ARBEF71523-982910.1146/annurev.bioeng.4.112601.125916 4, 261 (2002).
5. J. Knight, "Honey, I shrunk the lab," Nature NATUAS0028-083610.1038/418474a 418, 474 (2002).
6. G. M. Whitesides, "The origins and the future of microfluidics," Nature NATUAS0028-083610.1038/nature05058 442, 368 (2006).
7. H. A. Stone, A. D. Stroock, and A. Ajdari, "Engineering flows in small devices: Microfluidics toward a lab-on-a-chip," Annu. Rev. Fluid Mech. ARVFA30066-418910.1146/annurev.fluid.36.050802.122124 36, 381 (2004).
8. T. M. Squires and S. R. Quake, "Microfluidics: Fluid physics at the nanoliter scale," Rev. Mod. Phys. RMPHAT0034-686110.1103/ RevModPhys.77.977 77, 977 (2005).
9. J. M. Ottino and S. Wiggins, "Introduction: Mixing in microfluidics," Philos. Trans. R. Soc. London, Ser. APTRMAD0962-842810.1098/rsta.2003.1355 362, 923 (2004).
10. N.-T. Nguyen and Z. Wu, "Micromixers-A review," J. Micromech. Microeng. JMMIEZ0960-131710.1088/0960-1317/15/2/R01 15, R1 (2005).
11. A. D. Stroock, S. K. W. Dertinger, A. Ajdari, I. Mezic, H. A. Stone, and G. M. Whitesides, "Chaotic mixer for microchannels," Science SCIEAS0036-807510.1126/science.1066238 295, 647 (2002).
12. A. D. Stroock, G. J. McGraw, S. K. W. Dertinger, A. Ajdari, and G. M. Whitesides, "Investigation of the staggered herringbone mixer with a simple analytical model," Philos. Trans. R. Soc. London, Ser. APTRMAD0962-8428 362, 971 (2004).
13. R. H. Liu, M. A. Stremler, K. V. Sharp, M. G. Olsen, J. G. Santiago, R. J. Adrian, H. Aref, and D. Beebe, "Passive mixing in a three-dimensional serpentine microchannel," J. Microelectromech. Syst. JMIYET1057-715710.1109/84.846699 9, 190 (2000).
14. A. Sudarsan and V. M. Ugaz, "Fluid mixing in planar spiral microchannels," Lab Chip LCAHAM1473-019710.1039/b511524h 6, 74 (2006).
15. M. H. Oddy, J. G. Santiago, and J. C. Mikkelsen, "Electrokinetic instability micromixing," Anal. Chem. ANCHAM0003-270010.1021/ ac0155411 73, 5822 (2001).
16. L.-H. Lu, K. S. Ryu, and C. Liu, "A magnetic microstirrer and array for microfluidic mixing," J. Microelectromech. Syst. JMIYET1057-715710.1109/JMEMS.2002.802899 11, 462 (2002).
17. G. A. Mensing, T. M. Pearce, M. D. Graham, and D. J. Beebe, "An externally driven magnetic microstirrer," Philos. Trans. R. Soc. London, Ser. APTRMAD0962-8428 362, 1059 (2004).
18. K. S. Ryu, K. Shaikh, E. Glouch, Z. Fan, and C. Liu, "Micro magnetic stir-bar mixer integrated with parylene microfluidic channels," Lab Chip LCAHAM1473-019710.1039/b403305a 4, 608 (2004).
19. M. Yi, S. Qian, and H. H. Bau, "A magnetohydrodynamic chaotic stirrer," J. Fluid Mech. JFLSA70022-112010.1017/S0022112002001635 468, 153 (2002).
20. Z. Yang, H. Goto, M. Matsumoto, and R. Maeda, "Active micromixer for microfluidic systems using lead-zirconate-titanate (PZT) generated ultrasonic vibration," Electrophoresis ELCTDN0173-083510.1002/ (SICI)1522-2683(20000101)21:1<116::AID-ELPS116>3.0.CO;2-Y 21:116 (2000)
21. R. H. Liu, J. Yang, M. Z. Pindere, M. Athavale, and P. Grodzinski, "Bubble-induced acoustic micromixing," Lab Chip LCAHAM1473-019710.1039/b201952c 2, 151 (2002).
22. J. M. J. den Toonder, M. W. J. Prins, H. R. Stapert, and D. J. Broer, "Micro-fluidic system based on actuator elements," European Patent application WO2006087655 (2005).
23. J. J. L. Higdon, "The generation of feeding currents by flagellar motions," J. Fluid Mech. JFLSA70022-112010.1017/S002211207900104X 94, 305 (1979).
24. J. R. Blake and S. R. Otto, "Ciliary propulsion, chaotic filtration and a 'blinking' stokeslet," J. Eng. Math. JLEMAU0022-083310.1007/ BF00118828 30, 151 (1996).
25. S. R. Otto, A. N. Yannacopoulos, and J. R. Blake, "Transport and mixing in Stokes flow: The effect of chaotic dynamics on the blinking stokeslet," J. Fluid Mech. JFLSA70022-112010.1017/S0022112000002494 430, 1 (2001).
26. X.-L. Wu and A. Libchaber, "Particle diffusion in a quasi-two-dimensional bacterial bath," Phys. Rev. Lett. PRLTAO0031-900710.1103/PhysRevLett.84.3017 84, 3017 (2000).
27. M. J. Kim and K. S. Breuer, "Enhanced diffusion due to motile bacteria," Phys. Fluids PHFLE61070-663110.1063/1.1787527 16, L78 (2004).
28. N. Darnton, L. Turner, K. S. Breuer, and H. C. Berg, "Moving fluid with bacterial carpets," Biophys. J. BIOJAU0006-3495 86, 1863 (2004).
29. R. van Loon, P. D. Anderson, J. de Hart, and F. P. T. Baaijens, "A combined fictious domain/adaptive meshing method for fluid-structure interaction in heart valves," Int. J. Numer. Methods Fluids IJNFDW0271-209110.1002/fld.775 46, 533 (2004).
30. J. M. Ottino, The Kinematics of Mixing: Stretching, Chaos and Transport (Cambridge University Press, Cambridge, MA, 1989).
31. R. Glowinski, T.-W. Pan, T. I. Hesla, D. D. Joseph, and J. Periaux, "A distributed Lagrange multiplier/fictious domain method for flows around moving rigid bodies: Application to particulate flow," Int. J. Numer. Methods Fluids IJNFDW0271-209110.1002/ (SICI)1097-0363(19990830)30:8<1043::AID-FLD879>3.3.CO;2-P 30, 1043 (1999)
32. F. P. T. Baaijens, "A fictious domain/mortar element method for fluid-structure interaction," Int. J. Numer. Methods Fluids IJNFDW0271-209110.1002/ 1097-0363(20010415)35:7<743::AID-FLD109>3.0.CO;2-A 35, 43 (2001)
33. R. van Loon, P. D. Anderson, and F. N. van de Vosse, "A fluid-structure interaction method with solid-rigid contact for heart valve dynamics," J. Comput. Phys.JCTPAH0021-9991 217, 816 (2006).
34. P. R. Amestoy and I. S. Duff, "Vectorization of a multiprocessor multifrontal code," Int. J. Supercomput. Appl. IJSAE90890-272010.1007/BF00129647 3, 41 (1989).
35. P. R. Amestoy and I. S. Duff, "Memory management issues in sparse multifrontal methods on multiprocessors," Int. J. Supercomput. Appl. IJSAE90890-2720 7, 64 (1989).
36. P. R. Amestoy and C. Puglisi, "An unsymmetrized multifrontal LU factorization," SIAM J. Matrix Anal. Appl. SJMAEL0895-479810.1137/ S0895479800375370 24, 553 (2002).
37. A. Segal, SEPRAN Manual (Leidschendam, The Netherlands, 1995).
38. H. Aref, "Stirring by choatic advection," J. Fluid Mech. JFLSA70022-112010.1017/S0022112084001233 143, 1 (1984).
39. P. D. Anderson, O. S. Galaktionov, G. W. M. Peters, F. N. van de Vosse, and H. E. H. Meijer, "Chaotic fluid mixing in non-quasi-static time-periodic cavity flows," Int. J. Heat Fluid Flow IJHFD20142-727X10.1016/S0142-727X(99)00073-9 21, 176 (2000).
40. J. C. Lotters, W. Olthuis, P. H. Veltink, and P. Bergveld, "The mechanical properties of the rubber elastic polymer polydimethylsiloxane for sensor applications," Int. J. Numer. Methods Fluids IJNFDW0271-2091 7, 145 (1997).
41. M. A. Unger, H.-P. Chu, T. Thorsen, A. Scherer, and S. R. Quake, "Monolithic microfabricated valves and pumps by multilayer soft lithography," Science SCIEAS0036-807510.1126/science.288.5463.113 288, 113 (2000).
42. W. H. Press, S. A. Tuekolsky, W. T. Vetterling, and B. P. Flannerly, Numerical Recipes in Fortran (Cambridge University Press, Cambridge, MA, 1992).
43. A. Souvaliotis, S. Jana, and J. Ottino, "Potentialities and limitations of mixing simulations," AIChE J. AICEAC0001-154110.1002/ aic.690410702 41, 1605 (1995).
44. A. Galaktionov, P. Anderson, and G. Peters, "Mixing simulations: Tracking strongly deforming fluid volumes in 3D flows," in Recent Advances in Parallel Virtual Machine and Message Passing Interface, edited by M. Bubak, J. Dongarra, and J. Wasniniewski, Vol. 1332 of Lecture Notes in Computer Science (Springer, Berlin, 1997), pp. 463-469.
45. O. S. Galaktionov, P. D. Anderson, G. W. M. Peters, and F. N. van de Vosse, "An adaptive front tracking technique for three-dimensional transient flows," Int. J. Numer. Methods Fluids IJNFDW0271-209110.1002/ (SICI)1097-0363(20000130)32:2<201::AID-FLD934>3.0.CO;2-D 32, 201 (2000)
46. T. S. Krasnopolskaya, V. V. Meleshko, G. W. M. Peters, and H. E. H. Meijer, "Mixing in Stokes flow in an annular wedge cavity," Eur. J. Mech. B/Fluids EJBFEV0997-754610.1016/S0997-7546(99)00119-3 18, 793 (1999).
47. P. D. Anderson, O. S. Galaktionov, G. W. M. Peters, and H. E. H. Meijer, "Analysis of mixing in three-dimensional time-periodic cavity flows," J. Fluid Mech. JFLSA70022-112010.1017/S0022112099004541 386, 149 (1999).