Novel, potent THC/anandamide (hybrid) analogs

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 24, 2007, Pages 7850-7864

  Bourne, Caryl ^a   Roy, Sucharita ^a   Wiley, Jenny L ^b   Martin, Billy R ^b   Thomas, Brian F ^c   Mahadevan, Anu ^a   Razdan, Raj K ^a  

^a ORGANIX INC   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c RTI INTERNATIONAL   (United States)

Author keywords

Cannabinoids; Endocannabinoids; Hybrids; SAR

Indexed keywords

11 [3 (1,1 DIMETHYLHEPTYL)PHENOXY]UNDECA 5,8 DIENOIC ACID(1 HYDROXYPROPAN 2 YL)AMIDE; 11 [3 (5 AZIDO 1,1 DIMETHYLPENTYL)PHENOXY]UNDECA 5,8 DIENOIC ACID(1 HYDROXYPROPAN 2 YL)AMIDE; 11 [3 (5 CYANO 1,1 DIMETHYLPENTYL)PHENOXY]UNDECA 5,8 DIENOIC ACID(1 HYDROXYPROPAN 2 YL)AMIDE; 11 [3 (5 HYDROXY 1,1 DIMETHYLPENTYL)PHENYL]UNDECA 5,8 DIENOIC ACID(1 HYDROXYPROPAN 2 YL)AMIDE; 11 [4 (1,1 DIMETHYLHEPTYL)PHENOXY]UNDECA 5,8 DIENOIC ACID(1 HYDROXYPROPAN 2 YL)AMIDE; 12 [2 (1,1 DIMETHYLHEPTYL)PHENYL]DODECA 5,8,11 TRIENOIC ACID(1 HYDROXYPROPAN 2 YL)AMIDE; 12 [3 (5 BROMO 1,1 DIMETHYLPENTYL)PHENOXY]UNDECA 5,8 DIENOIC ACID(1 HYDROXYPROPAN 2 YL)AMIDE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; DRONABINOL; N (1 HYDROXYPROPAN 2 YL) 14 [3 (2 METHYLOCTAN 2 YL)PHENOXY]TETRADECA 5,8,11 TRIENAMIDE; O 2220; O 2243; O 2294; O 2655; O 2760; O 2781; O 2852; O 2874; OXYGEN; PHENOL; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VIVO STUDY; RECEPTOR AFFINITY; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ARACHIDONIC ACIDS; CELL LINE; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYUNSATURATED ALKAMIDES; RECEPTORS, CANNABINOID; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROCANNABINOL;

EID: 35348916131     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.039     Document Type: Article

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