Evaluation of the cholinergic and adrenergic effects of two tropane alkaloids from Erythroxylum pervillei

Phytotherapy Research

Volumn 21, Issue 10, 2007, Pages 1002-1005

  Chin, Young Won ^a   Kinghorn, A Douglas ^a   Patil, Popat N ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

( ) pervilleine A HCl; ( ) pervilleine H; Antiadrenergic activity; Anticholinergic activity; Tropane aromatic ester alkaloids

Indexed keywords

6 O 3,4,5 TRIMETHOXYCINNAMOYL ESTER; CARBACHOL; ERYTHROXYLUM PERVILLEI EXTRACT; ESTER DERIVATIVE; NORADRENALIN; PERVILLEINE A; PERVILLEINE H; PLANT EXTRACT; TROPANE ALKALOID; UNCLASSIFIED DRUG;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; ERYTHROXYLACEAE; ERYTHROXYLUM PERVILLEI; GUINEA PIG; MALE; MEDICINAL PLANT; MULTIDRUG RESISTANCE; NONHUMAN; RAT; SMOOTH MUSCLE CONTRACTION;

ADRENERGIC AGENTS; ADRENERGIC ALPHA-AGONISTS; ALKALOIDS; ANIMALS; AORTA; CARBACHOL; CHOLINERGIC AGENTS; CHOLINERGIC AGONISTS; ERYTHROXYLACEAE; GUINEA PIGS; ILEUM; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NOREPINEPHRINE; RATS; TROPANES; VAS DEFERENS;

CAVIA; ERYTHROXYLUM PERVILLEI; RATTUS;

EID: 35348885394     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2155     Document Type: Article

References (9)

1. Brown JH, Taylor P. 2001. Muscarinic receptor agonists and antagonists. In Goodman & Gilman's The Pharmacological Basis of Therapeutics, 10th edn, Hardmann JG, Limbird LE (eds). McGraw-Hill: New York, 155-173.
2. Catterall W, Mackie, K. 2001. Local anesthetics. In Goodman & Gilman's The Pharmacological Basis of Therapeutics, 10th edn, Hardmann JG, Limbird LE (eds). McGraw-Hill: New York, 367-384.
3. Chin Y-W, Jones WP, Waybright TJ et al. 2006. Tropane aromatic ester alkaloids from a large-scale re-collection of Erythroxylum pervillei stem bark obtained in Madagascar. J Nat Prod 69: 414-417.
4. Kinghorn AD, Pezzuto JM, Cui B, Silva GL, You M. 2006. Isolation of tropane alkaloid multidrug resistance inhibitors from Erythroxylum pervillei and their use for treatment of cancer and infections. US Patent 6989396 B2, Jan. 24.
5. Mi Q, Cui B, Chavez H et al. 2002. Characterization of tropane alkaloid aromatic esters that reverse the multidrug resistance phenotype. Anticancer Res 22: 1385-1397.
6. Mi Q, Cui B, Lantvit D et al. 2001. Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype. Cancer Res 61: 4030-4037.
7. Patil PN. 1996. Pharmacological quantitation. Indian J Exp Biol 34: 615-633.
8. Patil PN, Fudge K, Jacobowitz D. 1972. Steric aspects of adrenergic drugs. 18. α-adrenergic receptors of mammalian aorta. Eur J Pharmacol 19: 79-87.
9. Silva GL, Cui B, Chavez D et al. 2001. Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei. J Nat Prod 64: 1514-1520.