Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage

Experimental Dermatology

Volumn 16, Issue 11, 2007, Pages 927-935

  Jacobson, Myron K ^a,d   Kim, Hyuntae ^a,b   Coyle, Russell W ^a,b   Kim, Moonsun ^a,b   Coyle, Donna L ^a,b   Rizer, Ronald L ^c   Jacobson, Elaine L ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b Niadyne Development Inc   (United States)

^c Thomas J Stephens and Associates   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

Facial photodamage; Myristyl nicotinate; Retinoic acid; Skin barrier function

Indexed keywords

KI 67 ANTIGEN; LORICRIN; MYRISTYL NICOTINATE; NICOTINIC ACID DERIVATIVE; PLACEBO; RETINOIC ACID; UNCLASSIFIED DRUG; WATER;

ADULT; ARTICLE; BURNING SENSATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENTIATION; DRUG TOLERABILITY; DRY SKIN; EPIDERMIS; ERYTHEMA; FEMALE; HUMAN; HUMAN TISSUE; HYPOTHESIS; MAJOR CLINICAL STUDY; PERMEABILITY BARRIER; PHOTODERMATOSIS; RANDOMIZED CONTROLLED TRIAL; SELF EVALUATION; SKIN ABRASION; SKIN BIOPSY; SKIN IRRITATION; SKIN PERMEABILITY; SKIN PROTECTION; SKIN WATER LOSS; STRATUM CORNEUM; THICKNESS; TREATMENT OUTCOME;

ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FACE; FEMALE; HUMANS; KERATOLYTIC AGENTS; MEMBRANE PROTEINS; MIDDLE AGED; NIACIN; SKIN; SKIN AGING; TRETINOIN; ULTRAVIOLET RAYS; WATER;

EID: 35348863040     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2007.00616.x     Document Type: Article

References (38)

1. Fisher G J, Voorhees J J. Molecular mechanisms of retinoid actions in skin. FASEB J 1996: 10: 1002-1013.
2. Kligman A M, Grove G L, Hirose R, Leyden J J. Topical tretinoin for photoaged skin. J Am Acad Dermatol 1986: 15: 836-859.
3. Gendimenico G J, Mezick J A. Pharmacological effects of retinoids on skin cells. Skin Pharmacol 1993: 6 (Suppl. 1): 24-34.
4. Varani J, Warner R L, Gharaee-Kermani M, et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000: 114: 480-486.
5. Cho S, Lowe L, Hamilton T A, Fisher G J, Voorhees J J, Kang S. Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis. J Am Acad Dermatol 2005: 53: 769-774.
6. Olsen E A, Katz H I, Levine N, et al. Tretinoin emollient cream: A new therapy for photodamaged skin. J Am Acad Dermatol 1992: 26: 215-224.
7. Machtinger L A, Kaidbey K, Lim J, et al. Histological effects of tazarotene 0.1%cream vs. vehicle on photodamaged skin: A 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin. Br J Dermatol 2004: 151: 1245-1252.
8. Rittie L, Varani J, Kang S, Voorhees J J, Fisher G J. Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol 2006: 126: 732-739.
9. Eichner R, Gendimenico G J, Kahn M, Mallon J P, Capetola R J, Mezick J A. Effects of long-term retinoic acid treatment on epidermal differentiation in vivo: Specific modifications in the programme of terminal differentiation. Br J Dermatol 1996: 135: 687-695.
10. Hoal E, Wilson E L, Dowdle E B. Variable effects of retinoids on two pigmenting human melanoma cell lines. Cancer Res 1982: 42: 5191-5195.
11. Kang S, Bergfeld W, Gottlieb A B, et al. Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: A two-year, randomized, placebo-controlled trial. Am J Clin Dermatol 2005: 6: 245-253.
12. Zouboulis C C, Korge B, Akamatsu H, et al. Effects of 13-cis-retinoic acid, all- trans -retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro. J Invest Dermatol 1991: 96: 792-797.
13. Griffiths C E, Russman A N, Majmudar G, Singer R S, Hamilton T A, Voorhees J J. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med 1993: 329: 530-535.
14. Lowe N, Gifford M, Tanghetti E, et al. Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin: A multicenter, double-blind, randomized, parallel-group study. J Cosmet Laser Ther 2004: 6: 79-85.
15. Tagami H, Tadaki T, Obata M, Koyama J. Functional assessment of the stratum corneum under the influence of oral aromatic retinoid (etretinate) in guinea-pigs and humans. Comparison with topical retinoic acid treatment. Br J Dermatol 1992: 127: 470-475.
16. Varani J, Fligiel H, Zhang J, et al. Separation of retinoid-induced epidermal and dermal thickening from skin irritation. Archives of dermatological research 2003: 295: 255-262.
17. Wood L C, Elias P M, Calhoun C, Tsai J C, Grunfeld C, Feingold K R. Barrier disruption stimulates interleukin-1 alpha expression and release from a pre-formed pool in murine epidermis. J Invest Dermatol 1996: 106: 397-403.
18. Blanton R A, Kupper T S, McDougall J K, Dower S. Regulation of interleukin 1 and its receptor in human keratinocytes. Proc Natl Acad Sci U S A 1989: 86: 1273-1277.
19. Ya-Xian Z, Suetake T, Tagami H. Number of cell layers of the stratum corneum in normal skin -relationship to the anatomical location on the body, age, sex and physical parameters. Arch Dermatol Res 1999: 291: 555-559.
20. de Jongh C M, Jakasa I, Verberk M M, Kezic S. Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate. Br J Dermatol 2006: 154: 651-657.
21. Jacobson E L, Kim H, Kim M, Wondrak G T, Jacobson M K. Developing topical prodrugs for skin cancer prevention. In: Alberts D S, Hess L M, eds. Fundamentals of Cancer Prevention. Berlin/Heidelberg: Springer-Verlag, 2005: 139-160.
22. Jacobson E L, Kim H, Kim M, et al. A topical lipophillic niacin derivative increases NAD, epidermal differentiation, and barrier function in photodamaged skin. Exp Dermatol 2007: 16: 490-499.
23. Fitzpatrick T B. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 1988: 124: 869-871.
24. Glogau R G. Aesthetic and anatomic analysis of the aging skin. Semin Cutan Med Surg 1996: 15: 134-138.
25. Matkowskyj K A, Cox R, Jensen R T, Benya R V. Quantitative immunohistochemistry by measuring cumulative signal strength accurately measures receptor number. J Histochem Cytochem 2003: 51: 205-214.
26. Fluhr J W, Feingold K R, Elias P M. Transepidermal water loss reflects permeability barrier status: Validation in human and rodent in vivo and ex vivo models. Exp Dermatol 2006: 15: 483-492.
27. Jakasa I, de Jongh C M, Verberk M M, Bos J D, Kezic S. Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. Br J Dermatol 2006: 155: 104-109.
28. Gibbs S, Backendorf C, Ponec M. Regulation of keratinocyte proliferation and differentiation by all- trans -retinoic acid, 9- cis -retinoic acid and 1,25-dihydroxy vitamin D3. Arch Dermatol Res 1996: 288: 729-738.
29. Monteiro-Riviere N A, Bristol D G, Manning T O, Rogers R A, Riviere J E. Interspecies and interregional analysis of the comparative histologic thickness and laser Doppler blood flow measurements at five cutaneous sites in nine species. J Invest Dermatol 1990: 95: 582-586.
30. Bhawan J, Olsen E, Lufrano L, Thorne E G, Schwab B, Gilchrest B A. Histologic evaluation of the long term effects of tretinoin on photodamaged skin. J Dermatol Sci 1996: 11: 177-182.
31. Weinstein G D, Nigra T P, Pochi P E, et al. Topical tretinoin for treatment of photodamaged skin. A multicenter study. Arch Dermatol 1991: 127: 659-665.
32. Tur E, Hohl D, Jetten A, Panizzon R, Frenk E. Modification of late epidermal differentiation in photoaged skin treated with topical retinoic acid cream. Dermatology 1995: 191: 124-128.
33. Elias P M. Stratum corneum defensive functions: An integrated view. J Invest Dermatol 2005: 125: 183-200.
34. Segre J A. Epidermal barrier formation and recovery in skin disorders. J Clin Invest 2006: 116: 1150-1158.
35. Wickett R R, Visscher M O. Structure and function of the epidermal barrier. Am J Infect Control 2006: 34: S98-S110.
36. Levine N, Moon T E, Cartmel B, et al. Trial of retinol and isotretinoin in skin cancer prevention: A randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol Biomarkers Prev 1997: 6: 957-961.
37. Hageman G J, Stierum R H. Niacin, poly(ADP-ribose) polymerase-1 and genomic stability. Mutat Res 2001: 475: 45-56.
38. Kirkland J B. Niacin and carcinogenesis. Nutr Cancer 2003: 46: 110-118.