Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: A 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin

British Journal of Dermatology

Volumn 151, Issue 6, 2004, Pages 1245-1252

  Machtinger, L A ^a,b   Kaidbey, K ^c   Lim, J ^d   Loven, K H ^e   Rist, T E ^f   Wilson, D C ^g   Parizadeh, D D ^h   Sefton, J ^h   Holland, J M ^h   Walker, P S ^h  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b South Coast Medical Center   (United States)

^c Ivy Laboratories   (United States)

^d West Pharmaceutical Services   (United States)

^e Rivergate Dermatol/Skin Care Ctr   (United States)

^f Dermatology Associates of Knoxville   (United States)

^g Education and Research Foundation   (United States)

^h ALLERGAN INC   (United States)

Author keywords

Atypia; Histology; Photodamage; Randomized controlled trial; Retinoid; Tazarotene

Indexed keywords

DRUG VEHICLE; RETINOID; TAZAROTENE;

ADULT; AGED; ARTICLE; BURNING SENSATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DESQUAMATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; EDEMA; EPIDERMAL POLARITY; EPIDERMIS; ERYTHEMA; FACE; FACE PAIN; FACE SKIN; FEMALE; GRANULAR CELL; GRANULAR CELL LAYER; HISTOPATHOLOGIC SKIN REACTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; INTERCELLULAR SPACE; KERATINOCYTIC ATYPIA; MAJOR CLINICAL STUDY; MALE; MELANOCYTIC ATYPIA; MULTICENTER STUDY; PHOTODAMAGE; PHOTOTOXICITY; POLARIZATION; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; SKIN TOXICITY; STRATUM CORNEUM; WRINKLE;

ADULT; AGED; DOUBLE-BLIND METHOD; FACIAL DERMATOSES; FEMALE; HUMANS; HYPERPIGMENTATION; KERATINOCYTES; KERATOLYTIC AGENTS; MALE; MELANOCYTES; MIDDLE AGED; NICOTINIC ACIDS; SEVERITY OF ILLNESS INDEX; SKIN AGING; TREATMENT OUTCOME; VEHICLES;

EID: 19944409810     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2004.06186.x     Document Type: Article

References (14)

1. Leyden JJ, Grove GL, Grove MJ et al. Treatment of photodamaged facial skin with topical tretinoin. J Am Acad Dermatol 1989; 21: 638-44.
2. Sendagorta E, Lesiewicz J, Armstrong RB. Topical isotretinoin for photodamaged skin. J Am Acad Dermatol 1992; 27: S15-18.
3. Maddin S, Lauharanta J, Agache P et al. Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial. J Am Acad Dermatol 2000; 42: 56-63.
4. Phillips TJ, Gottlieb AB, Leyden JJ et al. Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial. Arch Dermatol 2002; 138: 1486-93.
5. Kang S. Latest findings for retinoids in photodamage. Paper presented at Academy 2001 Meeting of the American Academy of Dermatology; 29 July 2001; Anaheim, CA, U.S.A.
6. Sefton J, Kligman AM, Kopper SC et al. Photodamage pilot study: a double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel. J Am Acad Dermatol 2000; 43: 656-63.
7. Duvic M, Helekar B, Schulz C et al. Expression of a retinoid-inducible tumor suppressor, tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer. Clin Cancer Res 2000; 6: 3249-59.
8. Chandraratna RAS. Tazarotene-first of a new generation of receptor-selective retinoids. Br J Dermatol 1996; 135: 18-25.
9. Kligman AM, Grove GL, Hirose R, Leyden JJ. Topical tretinoin for photoaged skin. J Am Acad Dermatol 1986; 15: 836-59.
10. Kotrajaras R, Kligman AM. The effect of topical tretinoin on photodamaged facial skin: the Thai experience. Br J Dermatol 1993; 129: 302-9.
11. Bhawan J. Short- and long-term histologic effects of topical tretinoin on photodamaged skin, Int J Dermatol 1998; 37: 286-92.
12. Bhawan J, Palko MJ, Lee J et al. Reversible histologic effects of tretinoin on photodamaged skin. J Geriatr Dermatol 1995; 3: 62-7.
13. Bhawan J, Gonzalez-Serva A, Nehal K et al. Effects of tretinoin on photodamaged skin: a histologic study. Arch Dermatol 1991; 127: 666-72.
14. Weiss JS, Ellis CN, Headington JT et al. Topical tretinoin improves photoaged skin: a double-blind vehicle-controlled study. JAMA 1988; 259: 527-32.