NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 35, 2007, Pages 13954-13959

  Cheng, Wei ^a   Dumont, Sophie ^b,d   Tinoco Jr , Ignacio ^b   Bustamante, Carlos ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Hairpin; Molecular motors; Optical tweezers; Processivity

Indexed keywords

DOUBLE STRANDED RNA; MOLECULAR MOTOR; RNA HELICASE; VIRUS RNA; NS3 PROTEIN, HEPATITIS C VIRUS; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; DISSOCIATION; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA REPLICATION; RNA SEQUENCE; RNA STABILITY; SEQUENCE ANALYSIS; CHEMISTRY; CONFORMATION; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

HEPATITIS C VIRUS;

BASE SEQUENCE; HEPACIVIRUS; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS;

EID: 35348856329     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702315104     Document Type: Article

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