Matrine inhibits the activity of translation factor eIF4E through dephosphorylation of 4E-BP1 in gastric MKN45 cells

Planta Medica

Volumn 73, Issue 11, 2007, Pages 1176-1181

  Jiang, Tiejun ^a   Zhu, Yongliang ^a   Luo, Cong ^a   Lu, Xiaoyong ^a   Zhang, Wo ^a   Qiu, Fuming ^a   Huang, Jian ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

4E binding protein 1; Eukaryotic initiation factor 4E; Leguminosae; Matrine; Sophora flavescens

Indexed keywords

EUKARYOTIC INITIATION FACTOR; INITIATION FACTOR; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MATRINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STOMACH CANCER;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EUKARYOTIC INITIATION FACTOR-4E; HUMANS; PHOSPHOPROTEINS; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; QUINOLIZINES; SOPHORA; STOMACH NEOPLASMS;

EUKARYOTA; FABACEAE; SOPHORA FLAVESCENS;

EID: 35348827382     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-981592     Document Type: Article

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