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Volumn 11, Issue 5, 2007, Pages 842-845

A scaleable synthesis of dutasteride: A selective 5α-reductase inhibitor

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EID: 35348818187     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op700068g     Document Type: Article
Times cited : (31)

References (24)
  • 6
    • 35348860946 scopus 로고    scopus 로고
    • Batchelor, K. W.; Frye, S. V.; Dorsey, Jr., G. F.; Mook, Jr., R. A. U.S. Patent 5,565,467, 1996.
    • (a) Batchelor, K. W.; Frye, S. V.; Dorsey, Jr., G. F.; Mook, Jr., R. A. U.S. Patent 5,565,467, 1996.
  • 10
    • 0001002591 scopus 로고    scopus 로고
    • Bhattacharya, A.; DiMichele, L. M.; Dolling, Ulf.-H.; Douglas, A. W.; Grabowski, J. J. E. J. Am. Chem. Soc. 1988, 110, 3318-3319.
    • Bhattacharya, A.; DiMichele, L. M.; Dolling, Ulf.-H.; Douglas, A. W.; Grabowski, J. J. E. J. Am. Chem. Soc. 1988, 110, 3318-3319.
  • 11
    • 14244262196 scopus 로고    scopus 로고
    • Synthesis of 2-Iodo-1,4-bis(trifluoromethyl) Benzene (11). Diazotization of 1,4-bis(trifluoromethyl) aniline in the presence of sodium nitrite, hydrochloric acid, and water as medium generates diazonium ions, which will react with potassium iodide at 5-10 °C to obtain intermediate 11. equation presented Tetrakis(trifluoromethyl)biphenyls: Sidney, D. R.; Markarian, M.; Schwarz, M. J. Am. Chem. Soc. 1953, 75, 4967-4969.
    • Synthesis of 2-Iodo-1,4-bis(trifluoromethyl) Benzene (11). Diazotization of 1,4-bis(trifluoromethyl) aniline in the presence of sodium nitrite, hydrochloric acid, and water as medium generates diazonium ions, which will react with potassium iodide at 5-10 °C to obtain intermediate 11. equation presented Tetrakis(trifluoromethyl)biphenyls: Sidney, D. R.; Markarian, M.; Schwarz, M. J. Am. Chem. Soc. 1953, 75, 4967-4969.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.