Delivery of PEGylated drugs from mucoadhesive formulations by pH-induced disruption of H-bonded complexes of PEG-drug with poly(acrylic acid)

Reactive and Functional Polymers

Volumn 67, Issue 11 SPEC. ISS., 2007, Pages 1330-1337

  Hayashi, Yoshiki ^a,b   Milton Harris, J ^c   Hoffman, Allan S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c NEKTAR THERAPEUTICS   (United States)

Author keywords

Mucoadhesive polymers; PEG polyacrylic acid complexes; PEGylated drugs

Indexed keywords

DRUG DELIVERY; GELS; MOLECULAR WEIGHT; PH EFFECTS; POLYACRYLATES; PROTEINS;

MUCOADHESIVE POLYMERS; PEG POLYACRYLIC ACID COMPLEXES; PEGYLATED DRUGS;

POLYETHYLENE GLYCOLS;

EID: 35248884446     PISSN: 13815148     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reactfunctpolym.2007.08.005     Document Type: Article

References (27)

1. Park H., and Robinson J. Pharm. Res. 4 (1987)
2. Peppas N.A., and Sahlin J.J. Biomaterials 17 (1996) 1553
3. Iliopoulos L., and Audebert R. Polym. Bull. 13 (1995) 171
4. Krupers M.J., Van Der Gaag F.J., and Feijen J. Eur. Polym. J. 32 (1996) 785
5. Huang Y., Leobandung W., Foss A., and Peppas N.A. J. Contr. Rel. 65 (2000) 63
6. Goto T., Morishita M., Kavimandan N.J., Takayama K., and Peppas N.A. J. Pharm. Sci. 95 (2006) 462
7. Serra L., Domenech J., and Peppas N.A. Eur. J. Pharm. Biopharm. 63 (2006) 11
8. Sahlin J.J., and Peppas N.A. J. Biomater. Sci. Polym. Ed. 8 (1997) 421
9. Peppas N.A., Keys K.B., Torres-Lugo M., and Lowman A.M. J. Contr. Rel. 62 (1999) 81
10. Nakamura K., Maitani Y., Lowman A.M., Takayama K., Peppas N.A., and Nagai T. J. Contr. Rel. 61 (1999) 329
11. Varma M., Singla A.K., and Dhawan S. Drug Dev. Ind. Pharm. 30 (2004) 545
12. Lopez J.E., and Peppas N.A. J. Biomater. Sci. Polym. Ed. 15 (2004) 385
13. Blanchette J., Kavimandan N.J., and Peppas N.A. Biomed. Pharmacother. 58 (2004) 142
14. Hoffman A.S., Chen G.H., Kaang S.Y., Ding Z.L., Randeri K., and Kabra B. In: Ogata N., Kim S., Feijin J., and Okano T. (Eds). Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems (1996), Springer, Tokyo, New York 62
15. Saito H., Wu X., Harris J.M., and Hoffman A.S. Macromol. Rapid Commun. 18 (1997) 547
16. Chen G., Hoffman A.S., Kabra B., and Randeri K. In: Harris J.M., and Zalipsky S. (Eds). Chemistry and Biological Applications of Polyethylene Glycol. ACS Symposium Series vol. 680 (1997), American Chemical Society, Washington, DC (Chapter 27)
17. Inoue T., Chen G., Nakamae K., and Hoffman A.S. J. Contr. Rel. 49 (1998) 167
18. Inoue T., Chen G., Hoffman A.S., and Nakamae K. J. Bioact. Comp. Polym. 13 (1998) 50
19. Hoffman A.S., Chen G., Wu X., Ding Z., Matsuura J.E., and Gombotz W.R. In: Ottenbrite R. (Ed). Frontiers in Biomedical Polymer Applications (1999), Technomic Publishing Co., Lancaster 17
20. A.S. Hoffman, Y. Hayashi, US Patent 6,165,509, December 26, 2000.
21. Inoue T., Chen G., Nakamae K., and Hoffman A.S. J. Contr. Rel. 51 (1998) 221
22. Lele B.S., and Hoffman A.S. J. Biomater. Sci. Polym. Ed. 11 (2000) 1319
23. Lele B.S., and Hoffman A.S. J. Contr. Rel. 69 (2000) 237
24. Zhao X., and Harris J.M. In: Harris J.M., and Zalipsky S. (Eds). Chemistry and Biological Applications of Polyethylene Glycol. ACS Symposium Series vol. 680 (1997), American Chemical Society, Washington, DC (Chapter 28)
25. Zalipsky S. Adv. Drug Delver. Rev. 16 (1995) 157
26. Luessen H.L., Verhoef J.C., and Borchard G. Pharm. Res. 12 (1995) 1293
27. Jensen-Pippo K., Whitcomb K.L., DePrince R.B., and Habberfield A.D. Pharm. Res. 13 (1996) 102