메뉴 건너뛰기




Volumn 7, Issue 5, 2007, Pages 455-458

Clostridium difficile: new therapeutic options

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIDIARRHEAL AGENT; CLINDAMYCIN; IMMUNOGLOBULIN; METRONIDAZOLE; NITAZOXANIDE; OLIGOFRUCTOSE; PLACEBO; PREBIOTIC AGENT; PROBIOTIC AGENT; RAMOPLANIN; RIFAMPICIN; RIFAXIMIN; TOLEVAMER; TOXOID; UNCLASSIFIED DRUG; VANCOMYCIN;

EID: 35248851268     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2007.05.007     Document Type: Review
Times cited : (10)

References (30)
  • 1
    • 33845634379 scopus 로고    scopus 로고
    • Past, present, and future therapies for Clostridium difficile-associated disease
    • Surowiec D., Kuyumjian A.G., Wynd M.A., and Cicogna C.E. Past, present, and future therapies for Clostridium difficile-associated disease. Ann Pharmacother 40 (2006) 2155-2163
    • (2006) Ann Pharmacother , vol.40 , pp. 2155-2163
    • Surowiec, D.1    Kuyumjian, A.G.2    Wynd, M.A.3    Cicogna, C.E.4
  • 2
    • 28844494086 scopus 로고    scopus 로고
    • An epidemic, toxin gene-variant strain of Clostridium difficile
    • The investigators evaluated 187 isolates of C. difficile from eight health care facilities by pulsed-field electrophoresis, describing the BI/NAP1 isolate, its putative virulence mechanisms, and association with epidemic CDAD.
    • McDonald L.C., Killgore G.E., Thompson A., Owens Jr. R.C., Kazakova S.V., Sambol S.P., Johnson S., and Gerding D.N. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 353 (2005) 2433-2441. The investigators evaluated 187 isolates of C. difficile from eight health care facilities by pulsed-field electrophoresis, describing the BI/NAP1 isolate, its putative virulence mechanisms, and association with epidemic CDAD.
    • (2005) N Engl J Med , vol.353 , pp. 2433-2441
    • McDonald, L.C.1    Killgore, G.E.2    Thompson, A.3    Owens Jr., R.C.4    Kazakova, S.V.5    Sambol, S.P.6    Johnson, S.7    Gerding, D.N.8
  • 3
    • 32544446901 scopus 로고    scopus 로고
    • Severe Clostridium difficile-associated disease in populations previously at low risk - four states, 2005. MMWR Morb Mortal Wkly Rep 2005, 54:1201-1205.
  • 4
    • 29144473282 scopus 로고    scopus 로고
    • Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease
    • Dial S., Delaney J.A., Barkun A.N., and Suissa S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA 294 (2005) 2989-2995
    • (2005) JAMA , vol.294 , pp. 2989-2995
    • Dial, S.1    Delaney, J.A.2    Barkun, A.N.3    Suissa, S.4
  • 5
    • 33750689923 scopus 로고    scopus 로고
    • Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based study
    • Lowe D.O., Mamdani M.M., Kopp A., Low D.E., and Juurlink D.N. Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based study. Clin Infect Dis 43 (2006) 1272-1276
    • (2006) Clin Infect Dis , vol.43 , pp. 1272-1276
    • Lowe, D.O.1    Mamdani, M.M.2    Kopp, A.3    Low, D.E.4    Juurlink, D.N.5
  • 6
    • 33749338125 scopus 로고    scopus 로고
    • Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy
    • Dial S., Delaney J.A., Schneider V., and Suissa S. Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy. CMAJ 175 (2006) 745-748
    • (2006) CMAJ , vol.175 , pp. 745-748
    • Dial, S.1    Delaney, J.A.2    Schneider, V.3    Suissa, S.4
  • 7
    • 28844441314 scopus 로고    scopus 로고
    • A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
    • A prospective study characterizing a Canadian outbreak (1703 patients) of CDAD associated with a high mortality because of the BI/NAP1 strain.
    • Loo V.G., Poirier L., Miller M.A., Oughton M., Libman M.D., Michaud S., Bourgault A.M., Nguyen T., Frenette C., Kelly M., et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 353 (2005) 2442-2449. A prospective study characterizing a Canadian outbreak (1703 patients) of CDAD associated with a high mortality because of the BI/NAP1 strain.
    • (2005) N Engl J Med , vol.353 , pp. 2442-2449
    • Loo, V.G.1    Poirier, L.2    Miller, M.A.3    Oughton, M.4    Libman, M.D.5    Michaud, S.6    Bourgault, A.M.7    Nguyen, T.8    Frenette, C.9    Kelly, M.10
  • 8
    • 33746643774 scopus 로고    scopus 로고
    • New drugs for Clostridium difficile infection
    • The author presents a review and editorial of recent therapeutics for CDAD, centered on nitazoxanide and tolevamer.
    • Bartlett J.G. New drugs for Clostridium difficile infection. Clin Infect Dis 43 (2006) 428-431. The author presents a review and editorial of recent therapeutics for CDAD, centered on nitazoxanide and tolevamer.
    • (2006) Clin Infect Dis , vol.43 , pp. 428-431
    • Bartlett, J.G.1
  • 9
    • 19344363493 scopus 로고    scopus 로고
    • Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada
    • The authors performed a retrospective review of 845 patients from one Canadian hospital with CDAD treated with metronidazole and found that rates of recurrence in 2003-2004 had more than doubled compared with 1991-2002.
    • Pepin J., Alary M.E., Valiquette L., Raiche E., Ruel J., Fulop K., Godin D., and Bourassa C. Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin Infect Dis 40 (2005) 1591-1597. The authors performed a retrospective review of 845 patients from one Canadian hospital with CDAD treated with metronidazole and found that rates of recurrence in 2003-2004 had more than doubled compared with 1991-2002.
    • (2005) Clin Infect Dis , vol.40 , pp. 1591-1597
    • Pepin, J.1    Alary, M.E.2    Valiquette, L.3    Raiche, E.4    Ruel, J.5    Fulop, K.6    Godin, D.7    Bourassa, C.8
  • 10
    • 23944507069 scopus 로고    scopus 로고
    • Treatment of Clostridium difficile-associated disease: old therapies and new strategies
    • The authors present a review of the history of CDAD and its treatment, the evolution of recurrent disease, and several of the newer agents which are under investigation.
    • Aslam S., Hamill R.J., and Musher D.M. Treatment of Clostridium difficile-associated disease: old therapies and new strategies. Lancet Infect Dis 5 (2005) 549-557. The authors present a review of the history of CDAD and its treatment, the evolution of recurrent disease, and several of the newer agents which are under investigation.
    • (2005) Lancet Infect Dis , vol.5 , pp. 549-557
    • Aslam, S.1    Hamill, R.J.2    Musher, D.M.3
  • 11
    • 33847714210 scopus 로고    scopus 로고
    • New definitions will help, but cultures are critical for resolving unanswered questions about Clostridium difficile
    • Gerding D.N. New definitions will help, but cultures are critical for resolving unanswered questions about Clostridium difficile. Infect Control Hosp Epidemiol 28 (2007) 113-115
    • (2007) Infect Control Hosp Epidemiol , vol.28 , pp. 113-115
    • Gerding, D.N.1
  • 12
    • 33644978353 scopus 로고    scopus 로고
    • Continuation of antibiotics is associated with failure of metronidazole for Clostridium difficile-associated diarrhea
    • The investigators performed an observational prospective study of 27 patients and found that patients who had 'offending' antibiotics discontinued all had improvement of their diarrhea, compared to improvement in only 59% of patients who had antibiotics continued.
    • Modena S., Gollamudi S., and Friedenberg F. Continuation of antibiotics is associated with failure of metronidazole for Clostridium difficile-associated diarrhea. J Clin Gastroenterol 40 (2006) 49-54. The investigators performed an observational prospective study of 27 patients and found that patients who had 'offending' antibiotics discontinued all had improvement of their diarrhea, compared to improvement in only 59% of patients who had antibiotics continued.
    • (2006) J Clin Gastroenterol , vol.40 , pp. 49-54
    • Modena, S.1    Gollamudi, S.2    Friedenberg, F.3
  • 13
    • 33846436449 scopus 로고    scopus 로고
    • Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain
    • The authors conducted this retrospective review of 165 patients with CDAD requiring ICU care from 2 tertiary care hospitals in Quebec, Canada, and found that select patients were less likely to die if an emergency colectomy was performed.
    • Lamontagne F., Labbe A.C., Haeck O., Lesur O., Lalancette M., Patino C., Leblanc M., Laverdiere M., and Pepin J. Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain. Ann Surg 245 (2007) 267-272. The authors conducted this retrospective review of 165 patients with CDAD requiring ICU care from 2 tertiary care hospitals in Quebec, Canada, and found that select patients were less likely to die if an emergency colectomy was performed.
    • (2007) Ann Surg , vol.245 , pp. 267-272
    • Lamontagne, F.1    Labbe, A.C.2    Haeck, O.3    Lesur, O.4    Lalancette, M.5    Patino, C.6    Leblanc, M.7    Laverdiere, M.8    Pepin, J.9
  • 14
    • 19344364596 scopus 로고    scopus 로고
    • Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole
    • The authors prospectively observed 207 patients with CDAD in a Veterans' Hospital who were treated with metronidazole and reported that 28% of patients had a recurrence of CDAD within 90 days.
    • Musher D.M., Aslam S., Logan N., Nallacheru S., Bhaila I., Borchert F., and Hamill R.J. Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole. Clin Infect Dis 40 (2005) 1586-1590. The authors prospectively observed 207 patients with CDAD in a Veterans' Hospital who were treated with metronidazole and reported that 28% of patients had a recurrence of CDAD within 90 days.
    • (2005) Clin Infect Dis , vol.40 , pp. 1586-1590
    • Musher, D.M.1    Aslam, S.2    Logan, N.3    Nallacheru, S.4    Bhaila, I.5    Borchert, F.6    Hamill, R.J.7
  • 16
    • 33746626011 scopus 로고    scopus 로고
    • Nitazoxanide for the treatment of Clostridium difficile colitis
    • The investigators performed a double-blinded, prospective, randomized-controlled trial of nitazoxanide versus metronidazole for CDAD and found them to have similar rates of sustained response to therapy.
    • Musher D.M., Logan N., Hamill R.J., DuPont H.L., Lentnek A., Gupta A., and Rossignol J.F. Nitazoxanide for the treatment of Clostridium difficile colitis. Clin Infect Dis 43 (2006) 421-427. The investigators performed a double-blinded, prospective, randomized-controlled trial of nitazoxanide versus metronidazole for CDAD and found them to have similar rates of sustained response to therapy.
    • (2006) Clin Infect Dis , vol.43 , pp. 421-427
    • Musher, D.M.1    Logan, N.2    Hamill, R.J.3    DuPont, H.L.4    Lentnek, A.5    Gupta, A.6    Rossignol, J.F.7
  • 17
    • 33845703357 scopus 로고    scopus 로고
    • Nitazoxanide versus metronidazole for Clostridium difficile-associated colitis
    • Young J.D., Mangino J.E., Stevenson K.B., and Koletar S.L. Nitazoxanide versus metronidazole for Clostridium difficile-associated colitis. Clin Infect Dis 44 (2007) 152-154
    • (2007) Clin Infect Dis , vol.44 , pp. 152-154
    • Young, J.D.1    Mangino, J.E.2    Stevenson, K.B.3    Koletar, S.L.4
  • 18
    • 33747603490 scopus 로고    scopus 로고
    • Prospective, randomized inpatient study of oral metronidazole versus oral metronidazole and rifampin for treatment of primary episode of Clostridium difficile-associated diarrhea
    • Lagrotteria D., Holmes S., Smieja M., Smaill F., and Lee C. Prospective, randomized inpatient study of oral metronidazole versus oral metronidazole and rifampin for treatment of primary episode of Clostridium difficile-associated diarrhea. Clin Infect Dis 43 (2006) 547-552
    • (2006) Clin Infect Dis , vol.43 , pp. 547-552
    • Lagrotteria, D.1    Holmes, S.2    Smieja, M.3    Smaill, F.4    Lee, C.5
  • 19
    • 33746656237 scopus 로고    scopus 로고
    • Tolevamer, a novel nonantibiotic polymer, compared with vancomycin in the treatment of mild to moderately severe Clostridium difficile-associated diarrhea
    • The investigators conducted a prospective randomized-controlled double-blinded Phase II trial of tolevamer in patients with mild to moderately severe CDAD compared with vancomycin demonstrating noninferiority of vancomycin and higher dose tolevamer.
    • Louie T.J., Peppe J., Watt C.K., Johnson D., Mohammed R., Dow G., Weiss K., Simon S., John Jr. J.F., Garber G., et al. Tolevamer, a novel nonantibiotic polymer, compared with vancomycin in the treatment of mild to moderately severe Clostridium difficile-associated diarrhea. Clin Infect Dis 43 (2006) 411-420. The investigators conducted a prospective randomized-controlled double-blinded Phase II trial of tolevamer in patients with mild to moderately severe CDAD compared with vancomycin demonstrating noninferiority of vancomycin and higher dose tolevamer.
    • (2006) Clin Infect Dis , vol.43 , pp. 411-420
    • Louie, T.J.1    Peppe, J.2    Watt, C.K.3    Johnson, D.4    Mohammed, R.5    Dow, G.6    Weiss, K.7    Simon, S.8    John Jr., J.F.9    Garber, G.10
  • 20
    • 33846018033 scopus 로고    scopus 로고
    • Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent
    • Fulco P., and Wenzel R.P. Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. Expert Rev Anti-Infect Ther 4 (2006) 939-945
    • (2006) Expert Rev Anti-Infect Ther , vol.4 , pp. 939-945
    • Fulco, P.1    Wenzel, R.P.2
  • 21
    • 0037373020 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube
    • Aas J., Gessert C.E., and Bakken J.S. Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis 36 (2003) 580-585
    • (2003) Clin Infect Dis , vol.36 , pp. 580-585
    • Aas, J.1    Gessert, C.E.2    Bakken, J.S.3
  • 22
    • 33846042589 scopus 로고    scopus 로고
    • Inappropriate use of meta-analysis to estimate efficacy of probiotics
    • Dendukuri N., and Brophy J. Inappropriate use of meta-analysis to estimate efficacy of probiotics. Am J Gastroenterol 102 (2007) 201-204
    • (2007) Am J Gastroenterol , vol.102 , pp. 201-204
    • Dendukuri, N.1    Brophy, J.2
  • 23
    • 33645455337 scopus 로고    scopus 로고
    • Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease
    • McFarland L.V. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 101 (2006) 812-822
    • (2006) Am J Gastroenterol , vol.101 , pp. 812-822
    • McFarland, L.V.1
  • 24
    • 33644843614 scopus 로고    scopus 로고
    • Treatment of first recurrences of Clostridium difficile-associated disease: waiting for new treatment options
    • Louie T.J. Treatment of first recurrences of Clostridium difficile-associated disease: waiting for new treatment options. Clin Infect Dis 42 (2006) 765-767
    • (2006) Clin Infect Dis , vol.42 , pp. 765-767
    • Louie, T.J.1
  • 25
    • 33644837200 scopus 로고    scopus 로고
    • Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec
    • Pepin J., Routhier S., Gagnon S., and Brazeau I. Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec. Can Clin Infect Dis 42 (2006) 758-764
    • (2006) Can Clin Infect Dis , vol.42 , pp. 758-764
    • Pepin, J.1    Routhier, S.2    Gagnon, S.3    Brazeau, I.4
  • 26
    • 0036311186 scopus 로고    scopus 로고
    • Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease
    • McFarland L.V., Elmer G.W., and Surawicz C.M. Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol 97 (2002) 1769-1775
    • (2002) Am J Gastroenterol , vol.97 , pp. 1769-1775
    • McFarland, L.V.1    Elmer, G.W.2    Surawicz, C.M.3
  • 27
    • 18144414625 scopus 로고    scopus 로고
    • Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study
    • Lewis S., Burmeister S., and Brazier J. Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study. Clin Gastroenterol Hepatol 3 (2005) 442-448
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 442-448
    • Lewis, S.1    Burmeister, S.2    Brazier, J.3
  • 28
    • 28044437962 scopus 로고    scopus 로고
    • Invasive Saccharomyces infection: a comprehensive review
    • Enache-Angoulvant A., and Hennequin C. Invasive Saccharomyces infection: a comprehensive review. Clin Infect Dis 41 (2005) 1559-1568
    • (2005) Clin Infect Dis , vol.41 , pp. 1559-1568
    • Enache-Angoulvant, A.1    Hennequin, C.2
  • 30
    • 33847630925 scopus 로고    scopus 로고
    • Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin
    • Johnson S., Schriever C., Galang M., Kelly C.P., and Gerding D.N. Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin. Clin Infect Dis 44 (2007) 846-848
    • (2007) Clin Infect Dis , vol.44 , pp. 846-848
    • Johnson, S.1    Schriever, C.2    Galang, M.3    Kelly, C.P.4    Gerding, D.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.