Alternative equations for whole-body protein synthesis and for fractional synthetic rates of proteins

Metabolism: Clinical and Experimental

Volumn 56, Issue 11, 2007, Pages 1550-1560

  Ramakrishnan, Rajasekhar ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID;

ARTICLE; LIPID OXIDATION; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STEADY STATE;

PROTEIN BIOSYNTHESIS; REPRODUCIBILITY OF RESULTS;

EID: 35248824646     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2007.06.023     Document Type: Article

References (43)

1. Matthews D.E., Motil K.J., Rohrbaugh D.K., et al. Measurement of leucine metabolism in man from a primed, continuous infusion of l-[1-3C]leucine. Am J Physiol Endocrinol Metab 238 (1980) E473-E479
2. 13C]leucine infusion. Metabolism 38 (1989) 248-255
3. Macallan D.C., Mcnurlan M.A., Milne E., et al. Whole-body protein turnover from leucine kinetics and the response to nutrition in human immunodeficiency virus infection. Am J Clin Nutr 61 (1995) 818-826
4. Cobelli C., Toffolo G., Bier D.M., et al. Models to interpret kinetic data in stable isotope tracer studies. Am J Physiol Endocrinol Metab 253 (1987) E551-E564
5. Cobelli C., Toffolo G., and Foster D.M. Tracer-to-tracee ratio for analysis of stable isotope tracer data-link with radioactive kinetic formalism. Am J Physiol Endocrinol Metab 262 (1992) E968-E975
6. Cobelli C., Saccomani M.P., Tessari P., et al. Compartmental model of leucine kinetics in humans. Am J Physiol Endocrinol Metab 261 (1991) E539-E550
7. Toffolo G., Foster D.M., and Cobelli C. Estimation of protein fractional synthetic rate from tracer data. Am J Physiol Endocrinol Metab 264 (1993) E128-E135
8. Foster D.M., Barrett P.H.R., Toffolo G., et al. Estimating the fractional synthetic rate of plasma apolipoproteins and lipids from stable-isotope data. J Lipid Res 34 (1993) 2193-2205
9. Garlick P.J., Mcnurlan M.A., Essen P., et al. Measurement of tissue protein-synthesis rates in-vivo-a critical analysis of contrasting methods. Am J Physiol Endocrinol Metab 266 (1994) E287-E297
10. Prod'homme M., Rochon C., Balage M., et al. Whole body leucine flux in HIV-infected patients treated with or without protease inhibitors. Am J Physiol Endocrinol Metab 290 (2006) E685-E693
11. Wolfe R.R., Goodenough R.D., Wolfe M.H., et al. Isotopic analysis of leucine and urea metabolism in exercising humans. J Appl Physiol 52 (1982) 458-466
12. Tauveron I., Charrier S., Champredon C., et al. Response of leucine metabolism to hyperinsulinemia under amino acid replacement in experimental hyperthyroidism. Am J Physiol Endocrinol Metab 269 (1995) E499-E507
13. Garlick P.J., Mcnurlan M.A., McHardy K.C., et al. Rates of nutrient utilization in man measured by combined respiratory gas analysis and stable isotopic labelling: effect of food intake. Hum Nutr: Clin Nutr 41 (1987) 177-191
14. Nissen S., and Haymond M.W. Effects of fasting on flux and interconversion of leucine and alpha-ketoisocaproate in vivo. Am J Physiol Endocrinol Metab 241 (1981) E72-E75
15. Matthews D.E., Schwarz H.P., Yang R.D., et al. Relationship of plasma leucine and alpha-ketoisocaproate during a l-[1-C-13]-labeled leucine infusion in man-a method for measuring human intracellular leucine tracer enrichment. Metab-Clin Exp 31 (1982) 1105-1112
16. Ramakrishnan R. Studying apolipoprotein turnover with stable isotope tracers-correct analysis is by modeling enrichments. J Lipid Res 47 (2006) 2738-2753
17. Barrett P.H.R., Chan D.C., and Watts G.F. Design and analysis of lipoprotein tracer kinetics studies in humans. J Lipid Res 47 (2006) 1607-1619
18. Wolfe R.R. Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis (1992), Wiley-Liss, New York
19. Adey D., Kumar R., McCarthy J.T., et al. Reduced synthesis of muscle proteins in chronic renal failure. Am J Physiol Endocrinol Metab 278 (2000) E219-E225
20. Nair K.S., Halliday D., and Griggs R.C. Leucine incorporation into mixed skeletal-muscle protein in humans. Am J Physiol Endocrinol Metab 254 (1988) E208-E213
21. O'Keefe S.J.D., Lee R.B., Li J., et al. Trypsin and splanchnic protein turnover during feeding and fasting in human subjects. Am J Physiol Gastrointest Liver Physiol 290 (2006) G213-G221
22. Toth M.J., Matthews D.E., Tracy R.P., et al. Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am J Physiol Endocrinol Metab 288 (2005) E883-E891
23. Yarasheski K.E., Zachwieja J.J., Gischler J., et al. Increased plasma Gln and Leu R-a and inappropriately low muscle protein synthesis rate in AIDS wasting. Am J Physiol Endocrinol Metab 38 (1998) E577-E583
24. Yarasheski K.E., Smith S.R., and Powderly W.G. Reducing plasma HIV RNA improves muscle amino acid metabolism. Am J Physiol Endocrinol Metab 288 (2005) E278-E284
25. Zachwieja J.J., Witt T.L., and Yarasheski K.E. Intravenous glutamine does not stimulate mixed muscle protein synthesis in healthy young men and women. Metab-Clin Exp 49 (2000) 1555-1560
26. Rennie M.J., Edwards R.H.T., Halliday D., et al. Muscle protein-synthesis measured by stable isotope techniques in man-the effects of feeding and fasting. Clin Sci 63 (1982) 519-523
27. Balagopal P., Bayne E., Sager B., et al. Effect of lifestyle changes on whole-body protein turnover in obese adolescents. Int J Obes 27 (2003) 1250-1257
28. Balagopal P., Olney R., Darmaun D., et al. Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy. Am J Physiol Endocrinol Metab 290 (2006) E530-E539
29. Kalhan S.C., Rossi K.Q., Gruca L.L., et al. Relation between transamination of branched-chain amino acids and urea synthesis: evidence from human pregnancy. Am J Physiol Endocrinol Metab 275 (1998) E423-E431
30. Battezzati A., Benedini S., Fattorini A., et al. Effect of hypoglycemia on amino acid and protein metabolism in healthy humans. Diabetes 49 (2000) 1543-1551
31. Hovorka R., Carroll P.V., Gowrie I.J., et al. A surrogate measure of whole body leucine transport across the cell membrane. Am J Physiol Endocrinol Metab 276 (1999) E573-E579
32. Hsu J.W.C., Kriengsinyos W., Wykes L.J., et al. Leucine is not a good choice as an indicator amino acid for determining amino acid requirements in men. J Nutr 136 (2006) 958-964
33. Parhofer K.G., Barrett P.H.R., Bier D.M., et al. Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes. J Lipid Res 32 (1991) 1311-1323
34. Demant T., Packard C.J., Demmelmair H., et al. Sensitive methods to study human apolipoprotein B metabolism using stable isotope-labeled amino acids. Am J Physiol Endocrinol Metab 270 (1996) E1022-E1036
35. Nagashima K., Lopez C., Donovan D., et al. Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus. J Clin Invest 115 (2005) 1323-1332
36. Ballmer P.E., Mcnurlan M.A., Essen P., et al. Albumin synthesis rates measured with [2H5ring]phenylalanine are not responsive to short-term intravenous nutrients in healthy humans. J Nutr 125 (1995) 512-519
37. Garlick P.J. The role of leucine in the regulation of protein metabolism. J Nutr 135 (2005) 1553S-1556S
38. 13C]valine. Am J Physiol Endocrinol Metab 262 (1992) E372-E376
39. Shah O.J., Antonetti D.A., Kimball S.R., et al. Leucine, glutamine, and tyrosine reciprocally modulate the translation initiation factors eIF4F and eIF2B in perfused rat liver. J Biol Chem 274 (1999) 36168-36175
40. Anthony T.G., Anthony J.C., Yoshizawa F., et al. Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats. J Nutr 131 (2001) 1171-1176
41. Kimball S.R., Jefferson L.S., Nguyen H.V., et al. Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process. Am J Physiol Endocrinol Metab 279 (2000) E1080-E1087
42. Smith K., Reynolds N., Downie S., et al. Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein. Am J Physiol Endocrinol Metab 275 (1998) E73-E78
43. Caso G., Garlick P.J., Ballou L.M., et al. The increase in human muscle protein synthesis induced by food intake is similar when assessed with the constant infusion and flooding techniques. J Nutr 136 (2006) 1504-1510