Polymorphisms in the Interleukin-12/18 genes and recurrent spontaneous abortion

American Journal of Reproductive Immunology

Volumn 58, Issue 5, 2007, Pages 403-408

  Ostojić, Saša ^a   Volk, Marija ^b   Medica, Igor ^b   Kapović, Miljenko ^a   Meden vrtovec, Helena ^b   Peterlin, Borut ^b  

^a UNIVERSITY OF RIJEKA   (Croatia)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

Gene polymorphism; Interleukin 12; Interleukin 18; Recurrent spontaneous abortion

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 18;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; RECURRENT ABORTION; RISK ASSESSMENT; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; ADULT; CASE-CONTROL STUDIES; DNA; ELECTROPHORESIS, AGAR GEL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-18; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; VARIATION (GENETICS);

EID: 35148877408     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2007.00501.x     Document Type: Article

References (32)

1. Li TC, Makris M, Tomsu M, Tuckerman E, Laird S: Recurrent miscarriage: aetiology, managment and prognosis. Hum Reprod Update 2002; 8: 463-481.
2. Wilson R, Jenkins C, Miller H, McInnes IB, Moore J, McLean MA, Walker JJ: Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriage. Eur J Obstet Gynecol Reprod Biol 2004; 115: 51-54.
3. Laird SM, Tuckerman EM, Li TC: Cytokine expression in the endometrium of women with implantation failure and recurrent miscarriage. Reprod Biomed Online 2006; 13: 13-23.
4. Laird SM, Tuckerman EM, Cork BA, Linjawi S, Blakemore AI, Li TC: A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update 2003; 9: 163-174.
5. Chaouat G, Zourbas S, Ostojic S, Lappree-Delage G, Dubanchet S, Ledee N, Martal J: A brief review of recent data on some cytokine expressions at the materno-foetal interface which might callenge the classical Th1/Th2 dichotomy. J Reprod Immunol 2002; 53: 241-256.
6. Wegmann TG, Lin H, Guilbert L, Mosmann TR: Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a Th-2 phenomenon? Immunol Today 1993; 14: 353-356.
7. Chaouat G, Ledee-Bataille N, Zourbas S, Ostojic S, Dubanchet S, Martal J, Frydman R: Cytokines, implantation Rnd early abortion: re-examining the Th1/Th2 paradigm leads to question the single pathway, single therapy concept. Am J Reprod Immunol 2003; 50: 177-186.
8. Makhseed M, Raghupathy R, Azizieh F, Al-Azemi MM, Hassan NA, Bandar A: Mitogen-induced cytokine responses of maternal peripheral blood lymphocytes indicate a differential Th-type bias in normal pregnancy and pregnancy failure. Am J Reprod Immunol 1999; 42: 273-281.
9. Makhseed M, Raghupathy R, Azizieh F, Omu A, Al-Shamali E, Ashkanani L: Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 2001; 16: 2219-2226.
10. Jenkins C, Roberts J, Wilson R, MacLean MA, Shilito J, Walker JJ: Evidence of a T(H) 1 type response associated with recurrent miscarriage. Fertil Steril 2000; 73: 1206-1208.
11. Lim KJ, Odukoya OA, Ajjan RA, Li TC, Weetman AP, Cooke ID: The role of T helper cytokines in human reproduction. Fertil Steril 2000; 73: 136-142.
12. Bates MD, Quenby S, Takakuwa K, Johnson PM, Vince GS: Aberrant cytokine production by peripheral blood mononuclear cells in recurrent pregnancy loss? Hum Reprod 2002; 17: 2439-2444.
13. Shimada S, Kato EH, Morikawa M, Iwabuchi K, Nishida R, Kishi R, Onoe K, Minakami H, Yamada H: No difference in natural killer or natural killer T-cell population, but aberrant T-helper cell population in the endometrium of women with repeated miscarriage. Hum Reprod 2004; 19: 1018-1024.
14. Ledee-Bataille N, Dubanchet S, Coulomb-L'hermine A, Durand-Gasselin I, Frydman R, Chaouat G: A new role for natural killer cells, interleukin (IL)-12, and IL-18 in repeated implantation failure after in vitro fertilization. Fertil Steril 2004; 81: 59-65.
15. Loke YW, King A: Recent developments in the human maternal fetal immune interaction. Curr Opin Immunol 1991; 3: 762-766.
16. Croy BA, Chantakru S, Esadeg S, Ashkar AA, Wei Q: Decidual natural killer cells: Key regulators of placental development. J Reprod Immunol 2002; 57: 151-168.
17. Ledee-Bataille N, Bonnet-Chea K, Hosny G, Dubanchet S, Frydman R, Chaouat G: Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization-embryo transfer failure. Fertil Steril 2005; 83: 598-605.
18. Chaouat G, Ledee-Bataille N, Dubanchet S, Zourbas S, Sandra O, Martal J: Reproductive immunology 2003: Reassessing the Th1/Th2 paradigm? Immunol Lett 2004; 92: 207-214.
19. Ostojic S, Dubanchet S, Chaouat G, Abdelkarim M, Truyens C, Capron F: Demonstration of the presence of IL-16, IL-17 and IL-18 at the murine fetomaternal interface during murine pregnancy. Am J Reprod Immunol 2003; 49: 101-112.
20. Voest EE, Kenyen BM, O'Reilly MS, Tsuitt G, D'Amato RJ, Folkman J: Inhibition of angiogenesis by interleukin 12. J Natl Cancer Inst 1995; 87: 581-586.
21. Morahan G, Huang D, Wu M, Holt BJ, White GP, Kendall GE, Sly PD, Holt PG: Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet, 2002; 360: 455-459.
22. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K: Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995; 378: 88-91.
23. Okamura H, Kashiwamura S, Tsutsui H, Yoshimoto T, Nakanishi K: Regulation of interferon-gamma production by IL-12 and IL-18. Curr Opin Immunol 1998; 10: 259-264.
24. Giedraitis V, He B, Huang WX, Hillert J: Cloning and mutation analysis of the human IL-18 promoter: A possible role of polymorphisms in expression regulation. J Neuroimmunol 2001; 112: 146-152.
25. Tangri S, Raghupathy R: Expression of cytokines in placentas of mice undergoing immunologically-mediated spontaneous fetal resorbtion. Biol Reprod 1993; 49: 850-857.
26. Croy BA, Ashkar AA, Minhas K, Greenwood JD: Can murine uterine natural killer cells give insights into the pathogenesis of preeclampsia? J Soc Gynecol Investig 2000; 7: 12-20.
27. Naeimi S, Ghiam AF, Mojtahedi Z, Dehaghani AS, Amani D, Ghaderi A: Interleukin-18 gene promoter polymorphisms and recurrent spontaneous abortion. Eur J Obstet Gynecol Reprod Biol 2006; 128: 5-9.
28. Wilson R, Moor J, Jenkins C, Miller H, Walker JJ, McLean MA, Norman J, McInnes IB: Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage. Am J Reprod Immunol 2004; 51: 156-159.
29. Paradisi R, Porcu E, Venturoli S, Maldini-Casadei M, Boni P: Maternal serum levels of pro inflammatory cytokines in missed and threatened abortion. Am J Reprod Immunol 2003; 50: 302-308.
30. Ledee-Bataille N, Olivennes F, Kadoch J, Dubanchet S, Frydman N, Chaouat G, Frydman R: Detectable levels of interleukin-18 in uterine luminal secretions at oocyte retrieval predict failure of the embryo transfer. Hum Reprod 2004; 19: 1968-1973.
31. Xu D, Trajkovic V, Hunter D, Leung BP, Schulz K, Gracie JA, McInnes IB, Liew FY: IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background. Eur J Immunol 2000; 30: 3147-3156.
32. Smeltz RB, Chen J, Hu-Li J, Shevach EM: Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4. J Exp Med 2001; 194: 143-153.