The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation

Epilepsia

Volumn 48, Issue 10, 2007, Pages 1842-1849

  Palma, Eleonora ^a,b,c,f   Ragozzino, Davide ^a   Angelantonio, Silvia Di ^a   Mascia, Addolorata ^b,c   Maiolino, Francesca ^a   Manfredi, Mario ^b   Cantore, Giampaolo ^b   Esposito, Vincenzo ^b   Di Gennaro, Giancarlo ^b   Quarato, Pierpaolo ^b   Miledi, Ricardo ^d,e   Eusebi, Fabrizio ^a,b,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS NEUROMED   (Italy)

^c Italian National Olympic Committee   (Italy)

^d CENTRO DE FÍSICA APLICADA Y TECNOLOGÍA AVANZADA   (Mexico)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f Istituto Fisiologia Umana   (Italy)

Author keywords

Current; Epilepsy; GABAA receptor; Levetiracetam; Run down

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ETIRACETAM;

ADULT; AGED; ARTICLE; BRAIN; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG STABILITY; EPILEPTOGENESIS; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; ISOLATION PROCEDURE; MALE; MEMBRANE; MICROELECTRODE; NEOCORTEX; NERVE CELL NETWORK; OOCYTE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SUBICULUM; TEMPORAL LOBE EPILEPSY; VOLTAGE CLAMP; XENOPUS;

ADULT; AGED; ANIMALS; ANTICONVULSANTS; BRAIN TISSUE TRANSPLANTATION; CELL MEMBRANE; CHILD; EPILEPSY, TEMPORAL LOBE; FEMALE; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; HUMANS; MALE; MICROELECTRODES; NEOCORTEX; NEURAL INHIBITION; PATCH-CLAMP TECHNIQUES; PIRACETAM; PYRAMIDAL CELLS; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION; XENOPUS;

EID: 35148832613     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01131.x     Document Type: Article

References (21)

1. Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R. (2002) On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 298 1418 1421.
2. Doheny HC, Whittington MA, Jefferys JG, Patsalos PN. (2002) A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy. British Journal of Pharmacology 135 : 1425 1434.
3. Engel J. (2004) Natural history of mesial temporal lobe epilepsy with hippocampal sclerosis: how does kindling compare with other commonly used animal models? In Corcoran ME, Moshé SL (Eds) Kindling 6 (advances in behavioral biology). Vol. 35, Springer Science, New York, pp. 371 384.
4. Genton P, Sadzot B, Fejerman N, Peltola J, Despland PA, Steinhoff B, Rektor I, Wroe S, Maubrey MC, Vandervelden C, van Hammee G, Schlit AF, van Paesschen W 2006) Levetiracetam in a broad population of patients with refractory epilepsy: interim results of the international SKATE trial. Acta Neurologica Scandinavica 113 : 387 394.
5. Glien M, Brandt C, Potschka H, Loscher W 2002) Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy. Epilepsia 43 : 350 357.
6. Hovinga CA 2001) Levetiracetam: a novel antiepileptic drug. Pharmacotherapy 21 : 1375 88.
7. Lukyanetz EA, Shkryl VM, Kostyuk PG 2002) Selective blockade of N-type calcium channels by levetiracetam. Epilepsia 43 : 9 18.
8. Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B. (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proceedings of the National Academy of Sciences of the United States of America 101 : 9861 9866.
9. Miledi R. (1982) A calcium-dependent transient outward current in Xenopus laevis oocytes. Proceedings of the Royal Society of London. Series B, Biological Sciences 215 49l 497.
10. Miledi R, Eusebi F, Martínez-Torres A, Palma E, Trettel F. (2002) Expression of functional neurotransmitter receptors in Xenopus oocytes after injection with human brain membranes. Proceedings of the National Academy of Sciences of the United States of America 99 : 13238 13242.
11. Miledi R, Palma E, Eusebi F 2006) Microtransplantation of neurotransmitter receptors from cells to Xenopus oocyte membranes: New procedure for ion channel studies. Methods in Molecular Biology 322 347 355.
12. Nash EM, Sangha KS 2001) Levetiracetam. American Journal of Health-System Pharmacy 58 : 1195 1199.
13. Palma E, Ragozzino D, Di Angelantonio S, Spinelli G, Trettel F, Martinez-Torres A, Torchia G, Arcella A, Di Gennaro G, Quarato PP, Esposito V, Cantore G, Miledi R, Eusebi F. (2004) Phosphatase inhibitors remove the run-down of GABAA-receptors in human epileptic brain. Proceedings of the National Academy of Sciences of the United States of America 101 : 10183 10188.
14. Palma E, Torchia G, Limatola C, Trettel F, Arcella A, Cantore G, Di Gennaro G, Manfredi M, Esposito V, Quarato PP, Miledi R, Eusebi F. (2005a) BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America 102 : 1667 1672.
15. Palma E, Spinelli G, Torchia G, Martinez-Torres A, Ragozzino D, Miledi R, Eusebi F. (2005b) Abnormal GABAA receptors from human epileptic hippocampal subiculum microtransplanted to Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America 102 : 2514 2518.
16. Palma E, Amici M, Sombrero F, Spinelli G, Di Angelantonio S, Ragozzino D, Mascia A, Scoppetta C, Esposito V, Miledi R, Eusebi F. (2006) Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proceedings of the National Academy of Sciences of the United States of America 103 : 8465 8468.
17. Pisani A, Bonsi P, Martella G, De Persis C, Costa C, Pisani F, Bernardi G, Calabresi P. (2004) Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine. Epilepsia, 45 : 719 728.
18. Ragozzino D, Palma E, Di Angelantonio S, Amici M, Mascia A, Arcella A, Giangaspero F, Cantore G, Di Gennaro G, Manfredi M, Esposito V, Quarato PP, Miledi R, Eusebi F. (2005) Run-down of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America 102 : 15219 15223.
19. Rambeck B, Jurgens UH, May TW, Pannek HW, Behne F, Ebner A, Gorji A, Straub H, Speckmann Ej, Pohlmann-Eden B, Loscher W. (2006) Comparison of Brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentration of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy. Epilepsia 47 : 681 694.
20. Rocamora R, Wagner K, Schulze-Bonhange A. (2006) Levetiracetam reduces frequency and duration of epileptic activity in patients with refractory primary generalized epilepsy. Seizure 15 : 428 433.
21. Wieser HG. (2004) Mesial temporal lobe epilepsy with hippocampal sclerosis: report of the Commission on Neurosurgery. Epilepsia 45 : 695 714