Evidence for association and epistasis at the DAOA/G30 and D-amino acid oxidase loci in an Irish schizophrenia sample

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 144, Issue 7, 2007, Pages 949-953

  Corvin, A ^a   McGhee, K A ^a   Murphy, K ^a   Donohoe, G ^a   Nangle, J M ^a   Schwaiger, S ^a   Kenny, N ^a   Clarke, S ^a   Meagher, D ^b   Quinn, J ^b   Scully, P ^b   Baldwin, P ^b   Browne, D ^b   Walsh, C ^c   Waddington, J L ^b,d   Morris, D W ^a   Gill, M ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b St Davnet's Hospital   (Ireland)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Association; DAO; DAOA; Epistasis; Schizophrenia

Indexed keywords

DEXTRO AMINO ACID OXIDASE; N METHYL DEXTRO ASPARTIC ACID;

ARTICLE; CAUCASIAN; CONTROLLED STUDY; DAO GENE; DAOA GENE; EPISTASIS; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; HUMAN; IRELAND; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; SCHIZOPHRENIA;

CARRIER PROTEINS; CASE-CONTROL STUDIES; D-AMINO-ACID OXIDASE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; EPISTASIS, GENETIC; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IRELAND; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; VARIATION (GENETICS);

EID: 35148825001     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30452     Document Type: Article

References (24)

1. Addington AM, Gornick M, Sporn AL, Gogtay N, Greenstein D, Lenane M, Gochman P, Baker N, Balkisson R, Vakkalanka RK, Weinberger DR, Straub Re, Rapoport JL. 2004. Polymorphisms in the 13q33.2 gene G 72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. Biol Psychiatry 55:976-980.
2. Chumakov I, Blumenfeld M, Guerassimenko O, Caverec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen N, Cohen D. 2002. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. PNAS 99:13675-13680.
3. Cordell HJ. 2002. Epistasis: What it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 11:2463-2468.
4. Detera-Wadleigh S, McMahon FJ. 2006. G72/G30 in schizophrenia and bipolar disorder: Review and meta-analysis. Biol Psychiatry (In press).
5. Diagnostic and Statistical Manual of Mental Disorders. 2000. Fourth Edition. Text Revision. (DSM-IV-TR). Washington DC: American Psychiatric Association.
6. Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, Steel G, Nestadt G, Liang KY, Huganir RL, Valle D, Pulver A. 2005. Bipolar I disorder and schizophrenia: A 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am J Hum Genet 77(6):918-936.
7. Hall D, Gogos JA, Karayiorgou M. 2004. The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations. Genes Brain Behav 3:240-248.
8. Hashimoto K, Fukishima T, Shimizu E, Komatsu N, Watanabe H, Shinoda N, Nakazato M, Kumakiri C, Okada S, Hasegawa H, Imai K, Iyo M. 2003. Decreased serum levels of D-serine in patients with schizophrenia: Evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch Gen Psychiatry 572-576.
9. Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dehary D, Bernstein J, Bening-Abu-Schach U, Ben-Asher E, Lancet D, Ritsner M, Navon R. 2004. Is the G72/G30 locus associated with schizophrenia? Single nucleotide polymorphisms, haplotypes, and gene expression analysis. Biol Psychiatry 56:169-176.
10. Korostishevsky M, Kremer I, Kaganovich M, Cholostoy A, Murad I, Muhaheed M, Bannoura I, Rietschel M, Doubrusin M, Bening-Abu-Schach U, Belmaker RH, Maier W, Ebstein RP, Navon R. 2006. Transmission disequilibrium and haplotype analyses of the G72/G30 locus: suggestive linkage to schizophrenia in Palestinian Arabs living in the North of Israel. Am J Med Genet Part B Neuropsychiatr Genet 141B(1):91-95.
11. Liu X, He G, Wang X, Chen Q, Qian X, Li D, Gu N, Feng G, He L. 2004. Association of DAAO with schizophrenia in the Chinese population. Neurosci Lett 369:228-233.
12. Neale BM, Sham PC. 2004. The future of association studies: gene-based analysis and replication. Am J Hum Genet 75(3):353-362.
13. Nyholt DR. 2004. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74(4):765-769.
14. Schulze TG, Ohlraun S, Czerski PM, Schumacher J, Kassem L, Deschner M, Gross M, Tullius M, Heidmann V, Kovalenko S, Jamra RA, Becker T, Leszczynska-Rodziewicz A, Hauser J, Illig T, Klopp N, Wellek S, Cichon S, Henn FA, McMahon Fj, Maier W, Propping P, Nothen MM, Rietschel M. 2005. Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: A first step toward a molecular genetic classification of psychiatric phenotypes. Am J Psychiatry 162(11):2101-2108.
15. Schumacher J, Abon Jamra R, Freudenberg J, Becker T, Ohlraun S, Otte ACJ, Tullius M, Kovalenko S, Van Den Bogaert A, Maier W, Rietschel M, Propping P, Nothen M, Cichon S. 2004. Examination of G72 and D-amino acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry 9:203-207.
16. Schumacher J, Abon Jamra R, Becker T, Klopp N, Franke P, Jacob C, Sand P, Fritze J, Ohlraun J, Schulze TG, Rietschel M, Illig T, Propping P, Cichon S, Deckert J, Nothen MM. et al. 2005. Investigation of the DAOA/G30 locus in panic disorder. Mol Psychiatry 10(5):428-429.
17. Toro CT, Kasher PR, Deakin JFW. 2004. Altered D-serine metabolism in schizophrenia? A post-mortem study using the Stanley Consortium brains. Schizophr Res 67:125-126S.
18. Wang X, He G, Gu N, Yang J, Tang J, Chen Q, Liu X, Shen Y, Qian X, Lin W, Duam Y, Feng G, He L. 2004. Association of G72/G30 with schizophrenia in the Chinese population. Biochem Biophys Res Comm 319(4):1281-1286.
19. Williams NM, Williams H, Norton N, Spurlock G, Kirov G, Morris DW, Waddington JL, Gill M, Corvin A, Owen MJ, O'Donovan MC. 2003. Replication of schizophrenia susceptibility loci. Am J Med Genet Part B Neuropsychr Genet 122B:16-17.
20. Williams NM, Green EK, Macgregor S, Dwyer S, Norton N, Williams H, Raybould R, Grozeva D, Hamshere M, Zammit S, Jones L, Cardno A, Kirov G, Jones I, O'Donovan M, Owen MJ, Craddock N. 2006. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch Gen Psychiatry 63:366-373.
21. Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, Okuno A, Takao H, Toyota T, Minabe Y, Nakamura K, Shimizu E, Itokawa M, Mori N, Iyo M, Yoshikawa T. 2005. Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels. Biol Psychiatry 57:1493-1503.
22. Zhao JH, Sham PC. 2002. Faster allelic association analysis using unrelated subjects. Hum Hered 53(1):36-41.
23. Zhao JH, Lissarrague S, Essioux L, Sham PC. 2000. GENECOUNTING: Haplotype analysis with missing genotypes. Bioinformatics 18(12):1694-1695.
24. Zhou F, Li C, Duan S, Zheng Y, Gu N, Feng G, Xing Y, Shi J, He L. 2005. A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population. Schizophr Res 73(2-3):257-261.