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Volumn 42, Issue 9, 2007, Pages 529-544

Management of Parkinson disease: Current treatments, recent advances, and future development

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; APOMORPHINE; BENZATROPINE; BROMOCRIPTINE; CABERGOLINE; CARBIDOPA; CARBIDOPA PLUS ENTACAPONE PLUS LEVODOPA; CARBIDOPA PLUS LEVODOPA; CATECHOL METHYLTRANSFERASE INHIBITOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLOZAPINE; DOPAMINE RECEPTOR STIMULATING AGENT; ENTACAPONE; ERGOT DERIVATIVE; LEVODOPA; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; PERGOLIDE; PLACEBO; PRAMIPEXOLE; RASAGILINE; ROPINIROLE; ROTIGOTINE; SELEGILINE; TOCOPHEROL; TOLCAPONE; TRIHEXYPHENIDYL; TRIMETHOBENZAMIDE; UBIDECARENONE; UNINDEXED DRUG;

EID: 35048860925     PISSN: 1082801X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (58)
  • 3
    • 0037675042 scopus 로고    scopus 로고
    • Incidence of Parkinson's disease: Variation by age, gender, and race/ethnicity
    • Van Den Eeden SK, Tanner CM, Bernstein AL, et al. Incidence of Parkinson's disease: Variation by age, gender, and race/ethnicity. Am J Epidemiol. 2003;157:1015-1022.
    • (2003) Am J Epidemiol , vol.157 , pp. 1015-1022
    • Van Den Eeden, S.K.1    Tanner, C.M.2    Bernstein, A.L.3
  • 4
    • 0034658015 scopus 로고    scopus 로고
    • Impact of Parkinson's disease and its pharmacologic treatment on quality of life and economic outcomes
    • Scheife RT, Schumock GT, Burstein A, Gottwald MD, Luer MS. Impact of Parkinson's disease and its pharmacologic treatment on quality of life and economic outcomes. Am J Health Syst Pharm. 2000;57:953-962.
    • (2000) Am J Health Syst Pharm , vol.57 , pp. 953-962
    • Scheife, R.T.1    Schumock, G.T.2    Burstein, A.3    Gottwald, M.D.4    Luer, M.S.5
  • 5
    • 0042134524 scopus 로고    scopus 로고
    • Recent developments in the pharmacological treatment of Parkinson's disease
    • Tuite P, Riss J. Recent developments in the pharmacological treatment of Parkinson's disease. Expert Opin Investig Drugs. 2003;12:1335-1352.
    • (2003) Expert Opin Investig Drugs , vol.12 , pp. 1335-1352
    • Tuite, P.1    Riss, J.2
  • 8
    • 0034973443 scopus 로고    scopus 로고
    • An algorithm (decision tree) for the management of Parkinson's disease (2001): Treatment guidelines
    • Olanow CW, Watts RL, Koller WC. An algorithm (decision tree) for the management of Parkinson's disease (2001): Treatment guidelines. Neurology. 2001;56(11 suppl 5):S1-S88.
    • (2001) Neurology , vol.56 , Issue.11 SUPPL. 5
    • Olanow, C.W.1    Watts, R.L.2    Koller, W.C.3
  • 9
    • 33646104205 scopus 로고    scopus 로고
    • Suchowersky O, Gronseth G, Perlmutter J, Reich S, Zesiewicz T, Weiner WJ; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: Neuroprotective strategies and alternative therapies for Parkinson disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology [erratum in Neurology. 2006;67:299]. Neurology. 2006;66:976-982.
    • Suchowersky O, Gronseth G, Perlmutter J, Reich S, Zesiewicz T, Weiner WJ; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: Neuroprotective strategies and alternative therapies for Parkinson disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology [erratum in Neurology. 2006;67:299]. Neurology. 2006;66:976-982.
  • 10
    • 84888655746 scopus 로고    scopus 로고
    • Accessed August 7, 2007
    • Facts & Comparisons. http://www.factsandcomparisons.com. Accessed August 7, 2007.
    • Facts & Comparisons
  • 11
    • 84888677393 scopus 로고    scopus 로고
    • Accessed August 7, 2007
    • First DataBank. http://www.firstdatabank.com. Accessed August 7, 2007.
  • 12
    • 0037039267 scopus 로고    scopus 로고
    • Miyasaki JM, Martin W, Suchowersky O, Weiner WJ, Lang AE. Practice parameter: Initiation of treatment for Parkinson's disease: An evidence-based review: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2002;58:11-17.
    • Miyasaki JM, Martin W, Suchowersky O, Weiner WJ, Lang AE. Practice parameter: Initiation of treatment for Parkinson's disease: An evidence-based review: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2002;58:11-17.
  • 13
    • 33646076457 scopus 로고    scopus 로고
    • Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: Treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Pahwa R, Factor SA, Lyons KE, et al; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: Treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006;66:983-995.
    • (2006) Neurology , vol.66 , pp. 983-995
    • Pahwa, R.1    Factor, S.A.2    Lyons, K.E.3
  • 14
    • 84938465236 scopus 로고
    • Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease
    • Kostic V, Przedborski S, Flaster E, Sternic N. Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease. Neurology. 1991;41:202-205.
    • (1991) Neurology , vol.41 , pp. 202-205
    • Kostic, V.1    Przedborski, S.2    Flaster, E.3    Sternic, N.4
  • 15
    • 33745823166 scopus 로고    scopus 로고
    • Association of dopamine agonist use with impulse control disorders in Parkinson disease
    • Weintraub D, Siderowf AD, Potenza MN, et al. Association of dopamine agonist use with impulse control disorders in Parkinson disease. Arch Neurol. 2006;63:969-973.
    • (2006) Arch Neurol , vol.63 , pp. 969-973
    • Weintraub, D.1    Siderowf, A.D.2    Potenza, M.N.3
  • 16
    • 84888729494 scopus 로고    scopus 로고
    • FDA announces voluntary withdrawal of pergolide products, Washington, DC: US Food and Drug Administration; March 29, Accessed August 7
    • FDA announces voluntary withdrawal of pergolide products. Agency working with product manufacturers [press release]. Washington, DC: US Food and Drug Administration; March 29, 2007. http://www.fda.gov/bbs/topics/news/2007/ new01596.html. Accessed August 7, 2007.
    • (2007) Agency working with product manufacturers [press release]
  • 17
    • 0027931399 scopus 로고
    • The Sydney Multicentre Study of Parkinson's disease: A randomised, prospective five year study comparing low dose bromocriptine with low dose levodopa-carbidopa
    • Hely MA, Morris JG, Reid WG, et al. The Sydney Multicentre Study of Parkinson's disease: A randomised, prospective five year study comparing low dose bromocriptine with low dose levodopa-carbidopa. J Neurol Neurosurg Psychiatry. 1994;57:903-910.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 903-910
    • Hely, M.A.1    Morris, J.G.2    Reid, W.G.3
  • 18
    • 84888716684 scopus 로고    scopus 로고
    • Tasmar [package insert, Aliso Viejo, CA: Valeant Pharmaceuticals International; 2006
    • Tasmar [package insert]. Aliso Viejo, CA: Valeant Pharmaceuticals International; 2006.
  • 19
    • 0345019854 scopus 로고    scopus 로고
    • Selegiline delays the onset of disability in de novo parkinsonian patients. Swedish Parkinson Study Group
    • Palhagen S, Heinonen EH, Hagglund J, et al. Selegiline delays the onset of disability in de novo parkinsonian patients. Swedish Parkinson Study Group. Neurology. 1998;51:520-525.
    • (1998) Neurology , vol.51 , pp. 520-525
    • Palhagen, S.1    Heinonen, E.H.2    Hagglund, J.3
  • 20
    • 0027530638 scopus 로고
    • Effect of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • The Parkinson Study Group
    • The Parkinson Study Group. Effect of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med. 1993;328:176-183.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 21
    • 84888764251 scopus 로고    scopus 로고
    • Azilect [package insert, Kansas City, MO: Teva Neuroscience, Inc; 2006
    • Azilect [package insert]. Kansas City, MO: Teva Neuroscience, Inc; 2006.
  • 22
    • 0036894795 scopus 로고    scopus 로고
    • A controlled trial of rasagiline in early Parkinson disease: The TEMPO Study
    • Parkinson Study Group
    • Parkinson Study Group. A controlled trial of rasagiline in early Parkinson disease: The TEMPO Study. Arch Neurol. 2002;59:1937-1943.
    • (2002) Arch Neurol , vol.59 , pp. 1937-1943
  • 23
    • 2342655732 scopus 로고    scopus 로고
    • A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease
    • Parkinson Study Group
    • Parkinson Study Group. A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch Neurol. 2004;61:561-566.
    • (2004) Arch Neurol , vol.61 , pp. 561-566
  • 24
    • 13444302612 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: The PRESTO study
    • Parkinson Study Group
    • Parkinson Study Group. A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: The PRESTO study. Arch Neurol. 2005;62:241-248.
    • (2005) Arch Neurol , vol.62 , pp. 241-248
  • 25
    • 15844386001 scopus 로고    scopus 로고
    • LARGO study group. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, lasting effect in adjunct therapy with rasagiline given once daily, study): A randomised, double-blind, parallel-group trial
    • Rascol O, Brooks DJ, Melamed E, et al; LARGO study group. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, lasting effect in adjunct therapy with rasagiline given once daily, study): A randomised, double-blind, parallel-group trial. Lancet. 2005;365:947-954.
    • (2005) Lancet , vol.365 , pp. 947-954
    • Rascol, O.1    Brooks, D.J.2    Melamed, E.3
  • 26
    • 33646790126 scopus 로고    scopus 로고
    • Chen JJ, Ly AV. Rasagiline: A second-generation monoamine oxidase type-B inhibitor for the treatment of Parkinson's disease. Am J Health Syst Pharm. 2006;63:915-928.
    • Chen JJ, Ly AV. Rasagiline: A second-generation monoamine oxidase type-B inhibitor for the treatment of Parkinson's disease. Am J Health Syst Pharm. 2006;63:915-928.
  • 27
    • 2342426425 scopus 로고    scopus 로고
    • Zydis Selegiline Study Group. Zydis selegiline reduces off time in Parkinson's disease patients with motor fluctuations: A 3-month, randomized, placebo-controlled study
    • Waters CH, Sethi KD, Hauser RA, Molho E, Bertoni JM; Zydis Selegiline Study Group. Zydis selegiline reduces off time in Parkinson's disease patients with motor fluctuations: A 3-month, randomized, placebo-controlled study. Mov Disord. 2004;19:426-432.
    • (2004) Mov Disord , vol.19 , pp. 426-432
    • Waters, C.H.1    Sethi, K.D.2    Hauser, R.A.3    Molho, E.4    Bertoni, J.M.5
  • 28
    • 84888741343 scopus 로고    scopus 로고
    • Zelapar [package insert, Costa Mesa, CA: Valeant Pharmaceuticals International; 2006
    • Zelapar [package insert]. Costa Mesa, CA: Valeant Pharmaceuticals International; 2006.
  • 30
    • 33846438955 scopus 로고    scopus 로고
    • Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson disease
    • Watts RL, Jankovic J, Waters C, Rajput A, Boroojerdi B, Rao J. Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson disease. Neurology. 2007;68:272-276.
    • (2007) Neurology , vol.68 , pp. 272-276
    • Watts, R.L.1    Jankovic, J.2    Waters, C.3    Rajput, A.4    Boroojerdi, B.5    Rao, J.6
  • 31
    • 34247208187 scopus 로고    scopus 로고
    • SP 650 Study Group. Advanced Parkinson disease treated with rotigotine transdermal system: PREFER Study
    • LeWitt PA, Lyons KE, Pahwa R; SP 650 Study Group. Advanced Parkinson disease treated with rotigotine transdermal system: PREFER Study. Neurology. 2007;68:1262-1267.
    • (2007) Neurology , vol.68 , pp. 1262-1267
    • LeWitt, P.A.1    Lyons, K.E.2    Pahwa, R.3
  • 32
    • 84888681795 scopus 로고    scopus 로고
    • Neupro now approved in Europe for all stages of Parkinson's disease [press release]. Monheim, Germany: Schwarz Pharma; January 16, 2007. http://www.schwarzpharma.com/sp/n2587/press_releasejanuary_16_2007. Accessed August 7, 2007.
    • Neupro now approved in Europe for all stages of Parkinson's disease [press release]. Monheim, Germany: Schwarz Pharma; January 16, 2007. http://www.schwarzpharma.com/sp/n2587/press_releasejanuary_16_2007. Accessed August 7, 2007.
  • 33
    • 5144225838 scopus 로고    scopus 로고
    • Clinical trials of neuroprotection for Parkinson's disease
    • LeWitt PA. Clinical trials of neuroprotection for Parkinson's disease. Neurology. 2004;63(7 suppl 2):S23-S31.
    • (2004) Neurology , vol.63 , Issue.7 SUPPL. 2
    • LeWitt, P.A.1
  • 34
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker WD Jr, Boyson SJ, Parks JK. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol. 1989;26:719-723.
    • (1989) Ann Neurol , vol.26 , pp. 719-723
    • Parker Jr, W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 35
    • 0037426566 scopus 로고    scopus 로고
    • Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease
    • Muller T, Buttner T, Gholipour A, Kuhn W. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease. Neurosci Lett. 2003;341:201-204.
    • (2003) Neurosci Lett , vol.341 , pp. 201-204
    • Muller, T.1    Buttner, T.2    Gholipour, A.3    Kuhn, W.4
  • 36
    • 0036771852 scopus 로고    scopus 로고
    • Parkinson Study Group. Effects of coenzyme Q10 in early Parkinson disease: Evidence of slowing of the functional decline
    • Shults CW, Oakes D, Kieburtz K, et al; Parkinson Study Group. Effects of coenzyme Q10 in early Parkinson disease: Evidence of slowing of the functional decline. Arch Neurol. 2002;59:1541-1550.
    • (2002) Arch Neurol , vol.59 , pp. 1541-1550
    • Shults, C.W.1    Oakes, D.2    Kieburtz, K.3
  • 37
    • 33846115045 scopus 로고    scopus 로고
    • A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease
    • The NPNDS NET-PD Investigators
    • The NPNDS NET-PD Investigators. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology. 2007;68:20-28.
    • (2007) Neurology , vol.68 , pp. 20-28
  • 38
    • 34447252358 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease
    • for the German Coenzyme Q10 Study Group
    • Storch A, Jost WH, Vieregge P, et al; for the German Coenzyme Q10 Study Group. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. Arch Neurol. 2007;64:938-944.
    • (2007) Arch Neurol , vol.64 , pp. 938-944
    • Storch, A.1    Jost, W.H.2    Vieregge, P.3
  • 39
    • 0032914740 scopus 로고    scopus 로고
    • Creatine and cyclocreatine attenuate MPTP neurotoxicity
    • Matthews RT, Ferrante RJ, Klivenyi P, et al. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp Neurol. 1999;157:142-149.
    • (1999) Exp Neurol , vol.157 , pp. 142-149
    • Matthews, R.T.1    Ferrante, R.J.2    Klivenyi, P.3
  • 40
    • 33645894705 scopus 로고    scopus 로고
    • A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease
    • NINDS NET-PD Investigators
    • NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology. 2006;66:664-671.
    • (2006) Neurology , vol.66 , pp. 664-671
  • 41
    • 84888688050 scopus 로고    scopus 로고
    • Patient enrollment on target in National Institutes of Health phase III Parkinson's disease trial [press release]. Palo Alto, CA: Avicena Group, Inc; July 16, 2007. http://www.avicenagroup.com/news_events/press_releases/ 2007_07_16.php. Accessed August 7, 2007.
    • Patient enrollment on target in National Institutes of Health phase III Parkinson's disease trial [press release]. Palo Alto, CA: Avicena Group, Inc; July 16, 2007. http://www.avicenagroup.com/news_events/press_releases/ 2007_07_16.php. Accessed August 7, 2007.
  • 42
    • 84888682565 scopus 로고    scopus 로고
    • Prestwick Pharmaceuticals announces acquisition of rights to develop and commercialize lisuride in the U.S, press release, Washington, DC: Prestwick Pharmaceuticals, Inc; September 29, 2003. htrp://. Accessed August 7, 2007
    • Prestwick Pharmaceuticals announces acquisition of rights to develop and commercialize lisuride in the U.S. [press release]. Washington, DC: Prestwick Pharmaceuticals, Inc; September 29, 2003. htrp://www.prestwickpharma.com/news/ pr_03_9_29.htm. Accessed August 7, 2007.
  • 43
    • 84888680865 scopus 로고    scopus 로고
    • Lisuride Sub Q. Prestwick Pharmaceuticals website. http://www. prestwickpharma.com/products/pr_lisuridesubq.htm. Acccessed August 7, 2007.
    • Lisuride Sub Q. Prestwick Pharmaceuticals website. http://www. prestwickpharma.com/products/pr_lisuridesubq.htm. Acccessed August 7, 2007.
  • 46
    • 84888714792 scopus 로고    scopus 로고
    • SLV308 for treatment of patients with Parkinson's disease experiencing motor fluctuations. Clinical-Trials.gov.http://clinicaltrials.gov/ct/show/ nct00406588?order-1. Accessed August 7, 2007.
    • SLV308 for treatment of patients with Parkinson's disease experiencing motor fluctuations. Clinical-Trials.gov.http://clinicaltrials.gov/ct/show/ nct00406588?order-1. Accessed August 7, 2007.
  • 47
    • 34147154059 scopus 로고    scopus 로고
    • EASE-PD Adjunct Study Investigators. Ropinirole 24-hour prolonged release: Randomized, controlled study in advanced Parkinson disease
    • Pahwa R, Stacy MA, Factor SA, et al; EASE-PD Adjunct Study Investigators. Ropinirole 24-hour prolonged release: Randomized, controlled study in advanced Parkinson disease. Neurology. 2007;68:1108-1115.
    • (2007) Neurology , vol.68 , pp. 1108-1115
    • Pahwa, R.1    Stacy, M.A.2    Factor, S.A.3
  • 48
    • 35048875881 scopus 로고    scopus 로고
    • Safety and tolerability of ropinirole 24-hour prolonged release as adjunctive therapy to L-dopa in patients with Parkinson disease [abstract]
    • Poster P2201
    • Stocchi F, Stacy MA, Giorgi L, Earl NL. Safety and tolerability of ropinirole 24-hour prolonged release as adjunctive therapy to L-dopa in patients with Parkinson disease [abstract]. Eur J Neurol. 2006;13(suppl2):221. Poster P2201.
    • (2006) Eur J Neurol , vol.13 , Issue.SUPPL.2 , pp. 221
    • Stocchi, F.1    Stacy, M.A.2    Giorgi, L.3    Earl, N.L.4
  • 49
    • 84888657387 scopus 로고    scopus 로고
    • Once-daily Requip (ropinirole HCl) XL 24-hour extended-release tablets accepted for filing by U.S. FDA [press release]. London, England: SkyePharma PLC; April 13, 2007. http://ir.skyepharma.com/phoenix.zhtml?c=79810&p=irol- newsarticle&id=984508&highlight=. Accessed August 7, 2007.
    • Once-daily Requip (ropinirole HCl) XL 24-hour extended-release tablets accepted for filing by U.S. FDA [press release]. London, England: SkyePharma PLC; April 13, 2007. http://ir.skyepharma.com/phoenix.zhtml?c=79810&p=irol- newsarticle&id=984508&highlight=. Accessed August 7, 2007.
  • 50
    • 7144229372 scopus 로고    scopus 로고
    • Preclinical evaluation of PNU-151774E as a novel anticonvulsant
    • Fariello RG, McArthur R, Bonsignori A, et al. Preclinical evaluation of PNU-151774E as a novel anticonvulsant. J Pharmacol Exp Ther. 1998;285:397-403.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 397-403
    • Fariello, R.G.1    McArthur, R.2    Bonsignori, A.3
  • 51
    • 84888714374 scopus 로고    scopus 로고
    • Research & drug development:, Newron Pharmaceuticals website, Accessed August 7, 2007
    • Research & drug development: Safinamide. Newron Pharmaceuticals website. http://www.newron.com/safinamide.html. Accessed August 7, 2007.
    • Safinamide
  • 52
    • 0042467972 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons
    • Agnati LF, Ferre S, Lluis C, Franco R, Fuxe K. Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacol Rev. 2003;55:509-550.
    • (2003) Pharmacol Rev , vol.55 , pp. 509-550
    • Agnati, L.F.1    Ferre, S.2    Lluis, C.3    Franco, R.4    Fuxe, K.5
  • 53
    • 21244440664 scopus 로고    scopus 로고
    • Jenner P. Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease. Expert Opin Investig Drugs. 2005;14:729-738.
    • Jenner P. Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease. Expert Opin Investig Drugs. 2005;14:729-738.
  • 54
    • 84888651394 scopus 로고    scopus 로고
    • Submission of New Drug Application for istradefylline (KW-6002), an investigational anti-Parkinson's disease drug [press release]. Chiyoda-ku, Tokyo: Kyowa Hakko Kogyo Co, Ltd; April 27, 2006. http://www.kyowa.co.jp/eng/ netext/er070427_02.htm. Accessed August 7, 2007.
    • Submission of New Drug Application for istradefylline (KW-6002), an investigational anti-Parkinson's disease drug [press release]. Chiyoda-ku, Tokyo: Kyowa Hakko Kogyo Co, Ltd; April 27, 2006. http://www.kyowa.co.jp/eng/ netext/er070427_02.htm. Accessed August 7, 2007.
  • 55
    • 84888715792 scopus 로고    scopus 로고
    • Results of phase-III clinical studies of an anti-Parkinson's disease drug istradefylline (KW-6002) conducted overseas [press release]. Chiyoda-ku, Tokyo: Kyowa Hakko Kogyo Co, Ltd; March 7, 2006. http://www.kyowa.co.jp/eng/netext/ er060307.htm. Accessed August 7, 2007.
    • Results of phase-III clinical studies of an anti-Parkinson's disease drug istradefylline (KW-6002) conducted overseas [press release]. Chiyoda-ku, Tokyo: Kyowa Hakko Kogyo Co, Ltd; March 7, 2006. http://www.kyowa.co.jp/eng/netext/ er060307.htm. Accessed August 7, 2007.
  • 56
    • 84888668478 scopus 로고    scopus 로고
    • Preliminary study shows creatine and minocycline may warrant further study in Parkinson's disease [press release]. Washington, DC: National Institutes of Health; February 23, 2006. http://www.nih.gov/news/pr/feb2006/ ninds-23.htm. Accessed August 7, 2007.
    • Preliminary study shows creatine and minocycline may warrant further study in Parkinson's disease [press release]. Washington, DC: National Institutes of Health; February 23, 2006. http://www.nih.gov/news/pr/feb2006/ ninds-23.htm. Accessed August 7, 2007.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.