HLA and H2 class II transgenic mouse models to study susceptibility and protection in autoimmune thyroid disease

Autoimmunity

Volumn 36, Issue 6-7, 2003, Pages 397-404

  Kong, Yi Chi M ^a   Flynn, Jeffrey C ^a   Wan, Qiang ^a   David, Chella S ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Autoimmune thyroiditis; Autoimmunity; Class II interactions; Graves' disease model; H2 transgenes; HLA transgenes

Indexed keywords

DNA; H2 ANTIGEN; H2E ANTIGEN; HLA ANTIGEN; HLA DQ ANTIGEN; HLA DQ6 ANTIGEN; HLA DQ8 ANTIGEN; HLA DR ANTIGEN; HLA DR2 ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; PEPTIDE; THYROGLOBULIN; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN BINDING; AUTOIMMUNE DISEASE; DISEASE MODEL; DISEASE PREDISPOSITION; DISEASE RESISTANCE; DISEASE SEVERITY; GENE INTERACTION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GRAVES DISEASE; HUMAN; IMMUNIZATION; INHERITANCE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PROTECTION; REVIEW; STRAIN DIFFERENCE; THYROID DISEASE; THYROIDITIS; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; GENE TRANSFER TECHNIQUES; H-2 ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; MICE; MICE, TRANSGENIC; POLYMORPHISM, GENETIC; THYROGLOBULIN; THYROIDITIS, AUTOIMMUNE; TRANSGENES;

EID: 0141815956     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.1080/08916930310001603028     Document Type: Review

References (29)

1. Vladutiu, A.O. and Rose, N.R. (1971) "Autoimmune murine thyroiditis: Relation to histocompatibility (H-2) type", Science 174, 1137-1139.
2. Kong, Y.M. (1986) "The mouse model of autoimmune thyroid disease", In: McGregor, A.M., ed, Immunology of Endocrine Diseases (MTP Press Limited, Lancaster, UK), pp 1-24.
3. Kong, Y.M. (1999) "Experimental models for autoimmune thyroid disease: Recent developments", In: Volpe, R., ed, Contemporary Endocrinology: Autoimmune Endocrinopathies (Humana Press Inc., Totowa, NJ), pp 91-111.
4. Kong, Y.M., Lomo, L.C., Motte, R.W., Giraldo, A.A., Baisch, J., Strauss, G., Hämmerling, G.J. and David, C.S. (1996) "HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: Definitive association with HLA-DRB1*0301 (DR3) gene", J. Exp. Med. 184, 1167-1172.
5. Vaidya, B., Kendall-Taylor, P. and Pearce, S.H.S. (2002) "Genetics of endocrine disease: The genetics of autoimmune thyroid disease", J. Clin. Endocrinol. Metab. 87, 5385-5397.
6. Taneja, V. and David, C.S. (1999) "HLA class II transgenic mice as models of human diseases", Immunol. Rev. 169, 67-79.
7. Carayanniotis, G. and Rao, V.P. (1997) "Searching for pathogenic epitopes in thyroglobulin: Parameters and caveats", Immunol. Today 18, 83-88.
8. Kong, Y.M., David, C.S., Lomo, L.C., Fuller, B.E., Motte, R.W. and Giraldo, A.A. (1997) "Role of mouse and human class II transgenes in susceptibility to and protection against mouse autoimmune thyroiditis", Immunogenetics 46, 312-317.
9. Wan, Q., Shah, R., McCormick, D.J., Lomo, L.C., Giraldo, A.A., David, C.S. and Kong, Y.M. (1999) "H2-E transgenic class II-negative mice can distinguish self from nonself in susceptibility to heterologous thyroglobulins in autoimmune thyroiditis", Immunogenetics 50, 22-30.
10. Flynn, J.C., Fuller, B.E., Giraldo, A.A., Panos, J.C., David, C.S. and Kong, Y.M. (2001) "Flexibility of TCR repertoire and permissiveness of HLA-DR3 molecules in experimental autoimmune thyroiditis in nonobese diabetic mice", J. Autoimmun. 17, 7-15.
11. Wan, Q., Shah, R., Panos, J.C., Giraldo, A.A., David, C.S. and Kong, Y.M. (2002) "HLA-DR, LA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible", Human Immunol. 63, 301-310.
12. c congenic mice", Autoimmunity 27, 127-133.
13. Flynn, J.C., Wan, Q., Panos, J.C., McCormick, D.J., Giraldo, A.A., David, C.S. and Kong, Y.M. (2002) "Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis", J. Autoimmun. 18, 213-220.
14. Wan, Q., Motte, R.W., McCormick, D.J., Fuller, B.E., Giraldo, A.A., David, C.S. and Kong, Y.M. (1997) "Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis: Role of MHC class II", Clin. Immunol. Immunopathol. 85, 187-194.
15. β gene usage in experimental autoimmune thyroiditis", Ann. N. Y. Acad. Sci. 756, 450-452.
16. Kong, Y.M., McCormick, D.J., Wan, Q., Motte, R.W., Fuller, B.E., Giraldo, A.A. and David, C.S. (1995) "Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis: Secondary role of iodination", J. Immunol. 155, 5847-5854.
17. Lomo, L.C., Motte, R.W., Giraldo, A.A., Nabozny, G.H., David, C.S., Rimm, I.J. and Kong, Y.M. (1996) "Vβ8.2 transgene expression interferes with development of experimental autoimmune thyroiditis in CBA k/q but not k/k mice", Cell. Immunol. 168, 297-301.
18. + T cells in murine thyroglobulin-induced experimental autoimmune thyroiditis", Cell. Immunol. 159, 315-322.
19. + T cells", Cell. Immunol. 212, 63-70.
20. Caturegli, P., Vidalain, P.O., Vali, M., Aguilera-Galaviz, L.A. and Rose, N.R. (1997) "Cloning and characterization of murine thyroglobulin cDNA", Clin. Immunol. Immunopathol. 85, 221-226.
21. Flynn, J.C., Wan, Q., Brusic, V., McCormick, D.J., Panos, J.C., Giraldo, A.A., David, C.S. and Kong, Y.M. (2001) "Coexpression of susceptible and resistant HLA class II molecules and identification of pathogenic peptides in HLA-DR3-transgenic, H2A-negative mouse strains in autoimmune thyroiditis", J. Endocrinol. Investig. 24(6), 60.
22. + transgenic model of autoimmune thyroiditis inducible only with heterologous thyroglobulin", J. Endocrinol. Investig. 25(7), 30.
23. Shimojo, N., Kohno, Y., Yamaguchi, K., Kikuoka, S., Hoshioka, A., Niimi, H., Hirai, A., Tamura, Y., Saito, Y., Kohn, L.D. and Tahara, K. (1996) "Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule", Proc. Natl Acad. Sci. USA 93, 11074-11079.
24. Kaithamana, S., Fan, J., Osuga, Y., Liang, S-G. and Prabhakar, B.S. (1999) "Induction of experimental autoimmune Graves' disease in BALB/c mice", J. Immunol. 163, 5157-5164.
25. Costagliola, S., Many, M-C., Denef, J-F., Pohlenz, J., Refetoff, S. and Vassart, G. (2000) "Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease", J. Clin. Investig. 105, 803-811.
26. Nagayama, Y., Kita-Furuyama, M., Ando, T., Nakao, K., Mizuguchi, H., Hayakawa, T., Eguchi, K. and Niwa, M. (2002) "A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor", J. Immunol. 168, 2789-2794.
27. Rao, P.V., Watson, P.F., Weetman, A.P., Carayanniotis, G. and Banga, J.P. (2003) "Contrasting activities of thyrotropin receptor antibodies in experimental models of Graves' disease induced by injection of transfected fibroblasts or deoxyribonucleic acid vaccination", Endocrinology 144, 260-266.
28. Pichurin, P., Yan, X-M., Farilla, L., Guo, J., Chazenbalk, G.D., Rapoport, B. and McLachlan, S.M. (2001) "Naked TSH receptor DNA vaccination: A TH1 T cell response in which interferon-γ production, rather than antibody, dominates the immune response in mice", Endocrinology 142, 3530-3536.
29. Flynn, J.C., Rao, P.V., Gora, M., Alsharabi, G., Wei, W., Giraldo, A.A., David, C.S., Banga, J.P. and Kong, Y.M. (2003) "Graves' hyperthyroidism induced in HLA-DRB1*0301 (DR3) transgenic mice by immunization with thyrotropin receptor DNA", FASEB J. 17, C43. (Clin. Exp. Immunol., Submitted).