Structure-activity relationships of 2-aminothiazole derivatives as inducible nitric oxide synthase inhibitor

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 5, 2004, Pages 634-637

  Ueda, Shigeo ^a   Terauchi, Hideo ^a   Kawasaki, Motoji ^a   Yano, Akihiro ^a   Ido, Motoharu ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

2 aminothiazole; Inducible nitric oxide synthase inhibitor; Neuronal nitric oxide synthase (nNOS); Neuronal nitric oxide synthase inhibitor; Nitric oxide; Thiazole

Indexed keywords

(2 AMINO 4 METHYLTHIAZOL 5 YL)ACETIC ACID ETHYL ESTER; 2 AMINOTHIAZOLE DERIVATIVE; 2 IMINO 1,3 OXAZOLIDINE; 3 (2 AMINOTHIAZOL 4 YL)PROPIONIC ACID ETHYL ESTER; 4 (2 METHYL)PROPYLTHIAZOL 2 YLAMINE; 4 (2,2 DIMETHYL)PROPYLTHIAZOL 2 YLAMINE; 4 METHYL 4 PROPYL 2 IMINO 1,3 OXAZOLIDINE; 4 METHYL 5 (1 METHYL)ETHYLTHIAZOL 2 YLAMINE; 4 PENTYLTHIAZOL 2 YLAMINE; 4,5 DIMETHYLTHIAZOL 2 YLAMINE; 4,5,6 TRIHYDROCYCLOPENTA[D]THIAZOL 2 YLAMINE; 4,5,6,7 TETRAHYDROBENZO[D]THIAZOL 2 YLAMINE; 5 (1,1 DIMETHYL)ETHYL 4 METHYLTHIAZOL 2 YLAMINE; 5 BUTYL 4 METHYLTHIAZOL 2 YLAMINE; 5 METHYL 4 PROPYLTHIAZOL 2 YLAMINE; ALKYL GROUP; FUNCTIONAL GROUP; INDUCIBLE NITRIC OXIDE SYNTHASE; N (1 METHYL)ETHYL N' [5 (1 METHYL)ETHYL 4 METHYLTHIAZOL 2 YL]THIOUREA; N PHENYL N 4,5,6 TRIHYDROCYCLOPENTA[D]THIAZOL 2 YLAMINE; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OXAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG; 2-AMINOTHIAZOLE; AMINOTHIAZOLE; ENZYME INHIBITOR; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; NOS2 PROTEIN, RAT; THIAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; HYDROPHILICITY; MALE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; METABOLISM; WISTAR RAT;

ANIMALS; CELL LINE; ENZYME INHIBITORS; MALE; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 3042757659     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.634     Document Type: Article

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