A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention services

Canadian Journal of Psychiatry

Volumn 52, Issue 9, 2007, Pages 563-571

  Malla, Ashok ^a,b   Schmitz, Norbert ^a   Norman, Ross ^c   Archie, Suzanne ^d   Windell, Deborah ^c   Roy, Paul ^e   Zipursky, Robert B ^d  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

^e UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Early schizophrenia; Health system; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; CLOZAPINE; MOOD STABILIZER; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; RISPERIDONE;

ABSENCE OF SIDE EFFECTS; ADULT; ANALYSIS OF VARIANCE; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DISEASE DURATION; EDUCATION; ETHNICITY; FEMALE; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MENTAL HEALTH; MENTAL HEALTH SERVICE; OUTCOME ASSESSMENT; PSYCHOSIS;

EID: 34948903281     PISSN: 07067437     EISSN: 14970015     Source Type: Journal    
DOI: 10.1177/070674370705200904     Document Type: Article

References (30)

1. Ciompi L. Catamnestic long-term study on the course of life and aging of schizophrenics. Schizophr Bull. 1980;6:606-618.
2. Jablensky A, Sartorius N, Ernberg G, et al. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monograph Suppl. 1992;20:1-97.
3. Mason P, Harrison G, Glazebrook C, et al. Characteristics of outcome in schizophrenia at 13 years. Br J Psychiatry. 1995;167:596-603.
4. Harrow M, Grossman LS, Jobe TH, et al. Do patients with schizophrenia ever show periods of recovery? A 15-year multi-follow-up study. Schizophr Bull. 2005;31:723-734.
5. Rosen K, Garety P. Predicting recovery from schizophrenia: a retrospective comparison of characteristics at onset of people with single and multiple episodes. Schizophr Bull. 2005;31:735-750.
6. Harrison G, Hopper K, Craig T, et al. Recovery from psychotic illness: a 15- and 25-year international follow-up study. B J Psychiatry. 2001;178:506-517.
7. Malla AK, Norman RM, Joober R. First-episode psychosis, early intervention, and outcome: what have we learned? Can J Psychiatry. 2005;50:881-891.
8. Norman RM, Malla AK. Duration of untreated psychosis: a critical examination of the concept and its importance. Psychol Med. 2001;31:381-400.
9. Marshall M, Lewis S, Lockwood A, et al. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry. 2005;62:975-983.
10. Perkins DO, Gu H, Boteva K, et al. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry. 2005;162:1785-1804.
11. Malla A, Payne J. First-episode psychosis: psychopathology, quality of life, and functional outcome. Schizophr Bull. 2005;31:650-671.
12. Penn DL, Waldheter EJ, Perkins DO, et al. Psychosocial treatment for first-episode psychosis: a research update. Am J Psychiatry. 2005;162:2220-2232.
13. McGorry PD, Edwards J, Mihalopoulos C, et al. EPPIC: an evolving system of early detection and optimal management. Schizophr Bull. 1996;22:305-326.
14. Malla AK, Norman RM, Manchanda R, et al. One year outcome in first episode psychosis: influence of DUP and other predictors. Schizophr Res. 2002;54:231-342.
15. Malla A, Norman R, Schmitz N, et al. Predictors of rate and time to remission in first-episode psychosis: a two-year outcome study. Psychol Med. 2006;36:649-658.
16. Szymanski S, Lieberman JA, Alvir JM, et al. Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients. Am J Psychiatry. 1995;152:698-703.
17. Lieberman JA, Alvir JM, Koreen A, et al. Psychobiologic correlates of treatment response in schizophrenia. Neuropsychopharmacology. 1996;14:13S-21S.
18. Amminger GP, Resch F, Mutschlechner R, et al. Premorbid adjustment and remission of positive symptoms in first-episode psychosis. Eur Child Adolesc Psychiatry. 1997;6:212-218.
19. Perkins D, Lieberman J, Gu H, et al. Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders. Br J Psychiatry. 2004;185:18-24.
20. Harrigan SM, McGorry PD, Krstev H. Does treatment delay in first-episode psychosis really matter? Psychol Med. 2003;33:97-110.
21. Larsen TK, Melle I, Friis S, et al. One-year outcome in first episode nonaffective psychosis-earlier detection vs later detection. Schizophr Bull Suppl. 2004;70:36.
22. Larsen TK, Moe LC, Vibe-Hansen L, et al. Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis. Schizophr Res. 2000;45:1-9.
23. Archie S, Wilson JH, Woodward K, et al. Psychotic disorders clinic and first-episode psychosis: a program evaluation. Can J Psychiatry. 2005;50:46-51.
24. Malla A, Norman R, McLean T, et al. A Canadian programme for early intervention in non-affective psychotic disorders. Aust N Z J Psychiatry. 2003;37:407-413.
25. First MB, Spitzer RL, Gibbon M, et al. Structured clinical interview for the DSM-IV Axis I Disorders. Washington (DC): American Psychiatric Press; 1997.
26. Norman RM, Malla AK, Verdi MB, et al. Understanding delay in treatment for first-episode psychosis. Psychol Med. 2004;34:255-266.
27. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261-276.
28. Norman RM, Lewis SW, Marshall M. Duration of untreated psychosis and its relationship to clinical outcome. Br J Psychiatry Suppl. 2005;48:s19-23.
29. Ho BC, Andreasen NC, Flaum M, et al. Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophrenia. Am J Psychiatry. 2000;157:808-815.
30. Schmitz N, Malla A, Norman R, et al. Inconsistency in the relationship between duration of untreated psychosis (DUP) and negative symptoms: sorting out the problem of heterogeneity. Schizophr Res. 2007;93:152-159.