Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 271, Issue 2 40-2, 1996, Pages

  Scammell, Thomas E ^a,b   Elmquist, Joel K ^a   Saper, Clifford B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

body temperature; endotoxin; fever; hypothermia

Indexed keywords

CYTOKINE; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; NEUROPEPTIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME INACTIVATION; FEVER; HYPOTHERMIA; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; THERMOGENESIS; VASOMOTOR REFLEX;

EID: 0029813709     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.271.2.r333     Document Type: Article

References (31)

1. Baudry, N., and E. Vicaut. Role of nitric oxide in effects of tumor necrosis factor-aα on microcirculation in rat. J. Appl. Physiol. 75: 2392-2399, 1993.
2. Benzi, R. H., and L. Girardier. The response of adipose tissue blood flow to insulin-induced hypoglycemia in conscious dogs and rats. Pfluegers Arch. 406: 37-44, 1986.
3. Boje, K. M., and P. K. Arora. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587: 250-256, 1992.
4. Elmquist, J. K., T. E. Scammell, C. D. Jacobson, and C. B. Saper. Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide. J. Comp. Neurol. 371: 1-19, 1996.
5. Elmquist, J. K., T. E. Scammell, C. D. Jacobson, and C. B. Saper. Colocalization of fos-like immunoreactivity and nitric oxide synthase activity following immunological stimulation (Abstract). The Physiologist 37: A50, 1994.
6. Foster, D. O., and M. L. Frydman. Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis. Can. J. Physiol. Pharmacol. 57: 257-270, 1979.
7. Gordon, C. Thermal biology of the laboratory rat. Physiol. & Behav. 47: 963-991, 1989.
8. Huang, Z., P. L. Huang, N. Panahian, T. Dalkara, M. C. Fishman, and M. A. Moskowitz. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science Wash. DC 265: 1883-1885, 1994.
9. Iadecola, C., X. Xu, F. Zhang, J. Hu, and F. E. El. Prolonged inhibition of brain nitric oxide synthase by short-term systemic administration of nitro-L-arginine methyl ester. Neurochem. Res. 19: 501-505, 1994.
10. Ignarro, L. J., G. M. Buga, K. S. Wood, R. E. Byrns, and G. Chaudhuri. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84: 9265-9269, 1987.
11. Iyengar, R., D. J. Stuehr, and M. A. Marletta. Macrophage synthesis of nitrite, nitrate, and N-nitrosammes: precursors and role of the respiratory burst. Proc. Natl. Acad. Sci. USA 84: 6369-6373, 1987.
12. Kapas, L., J. Fang, and J. M. Krueger. Inhibition of nitric oxide synthesis inhibits rat sleep. Brain Res. 664: 189-196, 1994.
13. Kapas, L., M. Shibata, M. Kimura, and J. Krueger. Inhibition of nitric oxide synthesis suppresses sleep in rabbits. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R151-R157, 1994.
14. Karanth, S., K. Lyson, and S. M. McCann. Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami. Proc. Natl. Acad. Sci. USA 90: 3383-3387, 1993.
15. Kluger, M. J. Fever: role of pyrogens and cryogens. Physiol. Rev. 71: 93-127, 1991.
16. Long, N. C., S. L. Kunkel, A. J. Vander, and M. J. Kluger. Antiserum against tumor necrosis factor enhances lipopolysaccharide fever in rats. Am. J. Physiol. 258 (Regulators Integrative Comp. Physiol. 27): R332-R337, 1990.
17. Long, N., A. Morimoto, T. Nakamori, and N. Murakami. The effect of physical restraint in IL-1b- and LPS-induced fever. Physiol. Behav. 50: 625-628, 1991.
18. Long, N. C., A. Morimoto, T. Nakamori, and N. Murakami. Systemic injection of TNF-α attenuates fever due to IL-1β and LPS in rats. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R987-R991, 1992.
19. Long, N. C., I. Otterness, S. L. Kunkel, A. J. Vander, and M. J. Kluger. Roles of interleukin 1 beta and tumor necrosis factor in lipopolysaccharide fever in rats. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R724-R728, 1990.
20. Nagashima, T., H. Ohinata, and A. Kuroshima. Involvement of nitric oxide in noradrenaline-induced increase in blood flow through, brown adipose tissue. Life Sci. 54: 17-25, 1994.
21. Rees, D., R. Palmer, R. Schulz, H. Hodson, and S. Moncada. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101: 746-752, 1990.
22. Reimers, J. I., U. Bjerre, P. T. Mandrup, and J. Nerup. Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases. Cytokine 6: 512-520, 1994.
23. Rivier, C., and G. Shen. In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1β, vasopressin, and oxytocin. J. Neurosci. 14: 1985-1993, 1994.
24. Scammell, T. E., J. K. Elmquist, and C. B. Saper. Mechanism of hypothermia and hyperthermia during sepsis (Abstract). Ann. Neural. 38: 339, 1995.
25. Smith, B. K., and M. J. Kluger. Human IL-1 receptor antagonist partially suppresses LPS fever but not plasma levels of IL-6 in Fischer rats. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R653-R655, 1992.
26. Tiao, G., J. Rafferty, C. Ogle, J. Fischer, and P.-O. Hasselgren. Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6. Surgery St. Louis 116: 332-338, 1994.
27. Vincent, S., and H. Kimura. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46: 755-784, 1992.
28. Wan, W., L. Wetmore, C. M. Sorensen, A. H. Greenberg, and D. M. Nance. Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain. Brain Res. Bull. 34: 7-14, 1994.
29. Watkins, L. R., L. E. Goehler, J. K. Relton, N. Tartaglia, L. Silbert, D. Martin, and S. F. Maier. Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 183: 27-31, 1995.
30. Wilkinson, M., and Q. Pittman. Alteration of the physiological responses to indomethacin by endotoxin tolerance in the rat: a possible role for central vasopressin. J. Physiol. Lond. 479: 441-449, 1994.
31. Yamamoto, T., T. Kimura, K. Ota, M. Shoji, M. Inoue, M. Ohta, K. Sato, T. Funyu, and K. Abe. Effects of a nitric oxide synthase inhibitor on vasopressin and atrial natriuretic hormone release, thermogenesis and cardiovascular functions in response to interleukin-1 beta in rats. Tohoku J. Exp. Med. 174: 59-69, 1994.