A gene expression approach to study perturbed pathways in myositis

Current Opinion in Rheumatology

Volumn 19, Issue 6, 2007, Pages 536-541

  Greenberg, Steven A ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Dermatomyositis; Inclusion body myositis; Interferon; Plasmacytoid dendritic cell; Polymyositis

Indexed keywords

ALPHA1 INTERFERON; AMYLOID BETA PROTEIN; ANTIGEN; BETA1 INTERFERON;

AUTOIMMUNITY; BONE MARROW CELL; CELL INCLUSION; CELL MATURATION; CORRELATION ANALYSIS; DENDRITIC CELL; DERMATOMYOSITIS; DISEASE ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; LYMPHOCYTE; MEDICAL LITERATURE; MICROARRAY ANALYSIS; MYOSITIS; PLASMA CELL; POLYMYOSITIS; PRIORITY JOURNAL; PROTEIN INDUCTION; REVIEW; TISSUE INJURY; UPREGULATION;

GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; INTERFERON TYPE I; MYOSITIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 34948848066     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e3282efe261     Document Type: Review

References (28)

1. Greenberg SA, Sanoudou D, Haslett JN, et al. Molecular profiles of inflammatory myopathies. Neurology 2002; 59:1170-1182.
2. Tezak Z, Hoffman EP, Lutz JL, et al. Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis. J Immunol 2002; 168:4154-4163.
3. Zhou X, Dimachkie MM, Xiong M, et al. cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies. Med Sci Monit 2004; 10:BR191-BR197.
4. Greenberg SA, Pinkus JL, Pinkus GS, et al. Interferon-alpha/beta- mediated innate immune mechanisms in dermatomyositis. Ann Neurol 2005; 57:664-678.
5. Greenberg SA, Bradshaw EM, Pinkus JL, et al. Plasma cells in muscle in inclusion body myositis and polymyositis. Neurology 2005; 65:1782-1787.
6. Raju R, Dalakas MC. Gene expression profile in the muscles of patients with inflammatory myopathies: effect of therapy with IVIg and biological validation of clinically relevant genes. Brain 2005; 128:1887-1896.
7. Walsh RW, Kong SW, Yao Y, et al. Type 1 interferon-inducible blood gene expression is present and reflects disease activity in dermatomyositis and polymyositis. Arthritis Rheum 2007 (in press).
8. Baechler EC, Bauer JW, Slattery CA, et al. An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity. Mol Med 2007; 13:59-68.
9. Kea B, Pesich R, Chung LS, et al. Genomic analyses identify lipid metabolism abnormalities in dermatomyositis patients. J Invest Dermatol 2007; 127:S12.
10. Tian L, Greenberg SA, Kong SW, et al. Discovering statistically significant pathways in expression profiling studies. Proc Natl Acad Sci U S A 2005; 102:13544-13549.
11. Greenberg SA, Pinkus GS, Amato AA, Pinkus JL. Myeloid dendritic cells in inclusion-body myositis and polymyositis. Muscle Nerve 2007; 35:17-23. mDCs, central to the development of adaptive immune responses, are abundant in IBM and polymyositis muscle.
12. Arahata K, Engel AG. Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol 1984; 16:193-208.
13. McDouall RM, Dunn MJ, Dubowitz V. Nature of the mononuclear infiltrate and the mechanism of muscle damage in juvenile dermatomyositis and Duchenne muscular dystrophy. J Neurol Sci 1990; 99:199-217.
14. Wenzel J, Schmidt R, Proelss J, et al. Type I interferon- associated skin recruitment of CXCR3+ lymphocytes in dermatomyositis. Clin Exp Dermatol 2006; 31:576-582.
15. Page G, Chevrel G, Miossec P. Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis: interaction with chemokines and Th1 cytokine-producing cells. Arthritis Rheum 2004; 50:199-208.
16. Greenberg SA, Amato AA. Uncertainties in the pathogenesis of adult dermatomyositis. Curr Opin Neurol 2004; 17:359-364.
17. Gallardo E, de Andres I, Illa I. Cathepsins are upregulated by IFN-gamma/STAT1 in human muscle culture: a possible active factor in dermatomyositis. J Neuropathol Exp Neurol 2001; 60:847-855.
18. Illa I, Gallardo E, Gimeno R, et al. Signal transducer and activator of transcription 1 in human muscle: implications in inflammatory myopathies. Am J Pathol 1997; 151:81-88.
19. Raju R, Vasconcelos O, Granger R, Dalakas MC. Expression of IFN-gamma-inducible chemokines in inclusion body myositis. J Neuroimmunol 2003;141:125-131.
20. Greenberg SA. Proposed immunological models of the inflammatory myopathies and potential therapeutic implications. Neurology (in press).
21. O'Connor KA, Abbott KA, Sabin B, et al. MxA gene expression in juvenile dermatomyositis peripheral blood mononuclear cells: association with muscle involvement. Clin Immunol 2006; 120:319-325.
22. Engel AG, Arahata K. Monoclonal antibody analysis of mononuclear cells in myopathies. II: Phenotypes of autoinvasive cells in polymyositis and inclusion body myositis. Ann Neurol 1984; 16:209-215.
23. Bradshaw EM, Orihuela A, McArdel SL, et al. A local antigen-driven humoral response is present in the inflammatory myopathies. J Immunol 2007; 178:547-556. Whereas many papers have previously provided evidence for an antigen-directed T-cell response in IBM and polymyositis, this paper is the only study that has shown that an antigen-driven B-cell humoral immune response within muscle is occurring in dermatomyositis, IBM, and polymyositis.
24. Salajegheh M, Lin YY, Parker KC, et al. Using humoral immunity for the identification of candidate antigens in inclusion body myositis [abstract]. Neurology 2007; 68:A361.
25. Salajegheh M, Pinkus JL, Nazareno R, et al. Nodular infiltrates serving as sites of B cell maturation in muscle of patients with inclusion body myositis [abstract]. Neurology 2007; 68:A301.
26. Sugarman MC, Yamasaki TR, Oddo S, et al. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proc Natl Acad Sci U S A 2002; 99:6334-6339.
27. Sarkozi E, Askanas V, Johnson SA, et al. beta-Amyloid precursor protein mRNA is increased in inclusion-body myositis muscle. Neuroreport 1993; 4:815-818.
28. Askanas V, Sarkozi E, Bilak M, et al. Human muscle macrophages express beta-amyloid precursor and prion proteins and their mRNAs. Neuroreport 1995; 6:1045-1049.