Safety and effectiveness of tinzaparin sodium in the management of recurrent pregnancy loss

Clinical and Experimental Obstetrics and Gynecology

Volumn 34, Issue 3, 2007, Pages 143-145

  Dendrinos, S ^a   Kalogirou, I ^a,c   Makrakis, E ^a   Theodoridis, T ^b   Mahmound, E A ^b   Christopoulou Cokkinou, V ^b   Creatsas, G ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

^c NONE   (Greece)

Author keywords

Aspirin; Low molecular weight heparin; Recurrent pregnancy loss; Thrombophilia; Tinzaparin sodium

Indexed keywords

ACETYLSALICYLIC ACID; LOW MOLECULAR WEIGHT HEPARIN; TINZAPARIN;

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FETUS WASTAGE; HUMAN; INTRAUTERINE GROWTH RETARDATION; MAJOR CLINICAL STUDY; PREECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATION; PREGNANCY DISORDER; PRENATAL GROWTH; PROTEIN DEFICIENCY; RECOMMENDED DRUG DOSE; RECURRENT PREGNANCY LOSS; SOLUTIO PLACENTAE; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

ABORTION, HABITUAL; ADULT; ASPIRIN; FEMALE; FIBRINOLYTIC AGENTS; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; PREGNANCY; PREGNANCY OUTCOME; THROMBOPHILIA;

EID: 34948826334     PISSN: 03906663     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Regan L., Rai R.: "Epidemiology and medical causes of miscarriage". Best Pract. Res. Clin. Obstet. Gynaecol., 2000, 14, 839.
2. Dendrinos S., Makrakis E., Botsis D., Chassiakos D., Baka S., Creatsas G.: "A study of pregnancy loss in 352 women with recurrent miscarriages". Arch. Gynecol. Obstet., 2005, 271, 235.
3. Khare M., Nelson-Piercy C.: "Acquired thrombophilias and pregnancy". Best. Pract. Res. Clin. Obstet. Gynaecol., 2003, 17, 491.
4. Vinatier D., Dufour P., Cosson M., Houpeau J.L.: "Antiphospholopid syndrome and recurrent miscarriages". Eur. J. Obstet. Gynecol. Reprod. Biol., 2001, 96, 37.
5. Jody L., Kujovich P.: "Thrombophilia and pregnancy complications". Amer. J. Obst. Gyn., 2004, 191, 412.
6. Kupfermic M.J., Eldor A., Steinman N. et al.: "Increase frequency of genetic thrombophilia in women with complications of pregnancy". N. Engl. J. Med., 1999, 340, 9.
7. Brenner B.: "Inherited thrombophilia and pregnancy loss". Thromb. Haemost, 1999, 82, 634.
8. Brenner B., Sarig G., Weiner Z., Younis J., Blumenfeld Z., Lanir N.: "Thrombophilic polymorphisms are common in women with fetal loss without apparent cause". Thromb. Haemost, 1999, 82, 6.
9. Dizon-Townson D.S., Meline L., Nelson L.M., Varner M., Ward K.: "Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction". Am. J. Obstet. Gynecol., 1997, 177, 402.
10. Tormene D., Simioni P., Prandoni P., Luni S., Innella B., Sabbion P., Girolami A.: "The risk of fetal loss in family members of probands with factor V Leiden mutation". Thromb. Haemost, 1999, 82, 1237.
11. Meinardi J.R., Middeldorp S., de Kam P.J. et al.: "Increased risk for fetal loss in carriers of the factor V Leiden mutation". Ann. Intern. Med., 1999, 130, 736.
12. Younis J.S., Brenner B., Ohel G., Tal J., Lanir N., Ben-Ami M.: "Activated protein C resistance and factor V Leiden mutation can be associated with first-as well as second-trimester recurrent pregnancy loss". Am. J. Reprod. Immunol., 2000, 43, 31.
13. Rai R., Shlebak A., Cohen H., Backos M., Holmes Z., Marriott K., Regan L.: "Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage". Hum. Reprod., 2001, 16, 961.
14. Rey E., Kahn S.R., David M., Shrier I.: "Thrombophilic disorders and fetal loss, a meta-analysis". Lancet, 2003, 361, 901.
15. Many A., Elad R., Yaron Y., Eldor A., Lessing J.B., Kupferminc M.J.: "Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia". Obstet. Gynecol., 2002, 99 (5 Pt 1), 684.
16. Sanson B.J., Friederich P.W., Simioni P., Zanardi S., Hilsman M..V, Girolami A. et al.: "The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women". Thromb. Haemost, 1996, 75, 387.
17. Gris J.C., Quere I., Monpeyroux F., Mercier E., Ripart-Neveu S., Tailland M.L. et al.: "Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent-the Nimes Obstetricians and Haematologists Study5 (NOHA5)". Thromb. Haemost, 1999, 81, 891.
18. Preston F.E., Rosendaal F.R., Walker I.D. et al.: "Increased fetal loss in women with heritable thrombophilia". Lancet, 1996, 348, 913.
19. den Heijer M., Koster T., Blom H.J. et al.: " Hyperhomocysteinemia as a risk factor for deep-vein thrombosis". N. Engl. J. Med., 1996, 334, 759.
20. Nelen W.L., Blom H.J., Steegers E.A., den Heijer M., Eskes T.K.: "Hyperhomocysteinemia and recurrent early pregnancy loss, a meta-analysis". Fertil. Steril, 2000, 74, 1196.
21. Infante-Rivard C., Rivard G.E., Yotov W.V., Genin E., Guiguet M., Weinberg C. et al.: "Absence of association of thrombophilia polymorphisms with intrauterine growth restriction". N. Engl. J. Med., 2002, 347, 19.
22. Alfirevic Z., Mousa H.A., Martlew V., Briscoe L., Perez-Casal M., Toh C.H.: "Postnatal screening for thrombophilia in women with severe pregnancy complications". Obstet. Gynecol., 2001, 97 (5 Pt 1), 753.
23. Prochazka M., Happach C., Marsal K., Dahlback B., Lindqvist P.G.: "Factor V Leiden in pregnancies complicated by placental abruption". Br. J. Obstet. Gynaecol., 2003, 110, 462.
24. Facchinetti F., Marozio L., Grandone E., Pizzi C., Volpe A., Benedetto C.: "Thrombophilic mutations are a main risk factor for placental abruption". Haematologica, 2003, 88, 785.
25. von Tempelhoff G.F., Heilmann L., Spanuth E., Kunzmann E., Hommel G.: "Incidence of the factor V Leiden-mutation, coagulation inhibitor deficiency, and elevated antiphospholipid-antibodies in patients with preeclampsia or HELLP-syndrome. Hemolysis, elevated liver-enzymes, low platelets". Thromb. Res., 2000, 100, 363.
26. Witz J.I.: "Low molecular weights heparins". N. Engl. J. Med., 1997, 337, 688.
27. Pauzner R., Dulitski M., Langevitz P. et al.: "Low molecular weight heparin and warfarin in the treatment of patients with antiphospholipid syndrome during pregnancy". Thromb. Haemost. 2001, 86, 1379.
28. Norris L.A., Bonnar J., Smith M.P., Steer P.J., Savidge G.: "Low molecular weight heparin (tinzaparin) therapy for moderate risk thromboprophylaxis during pregnancy. A pharmacokinetic study". Thromb. Haemost., 2004, 92, 791.
29. Sephton V., Farquharson R.G., Topping J., Quenby S.M. et al.: "A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy". Obstet. Gynecol., 2003, 101, 1307.
30. Price M., Kelsberg G., Safranek S., Damitz B.: "Clinical inquiries. What treatments prevent miscarriage after recurrent pregnancy loss?". J. Fam. Pract., 2005, 54, 892.