Herbal medicine Yin Zhi Huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole

Acta Pharmacologica Sinica

Volumn 28, Issue 10, 2007, Pages 1685-1692

  Fan, Lan ^a   Wang, Guo ^a   Wang, Lian Sheng ^a   Chen, Yao ^a   Zhang, Wei ^a   Huang, Yuan Fei ^a   Huang, Rui Xue ^a   Hu, Dong Li ^a   Wang, Dan ^a   Zhou, Hong Hao ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

CYP2C19; CYP3A4; Induction; Omeprazole; Yin Zhi Huang

Indexed keywords

5 HYDROXYOMEPRAZOLE; CYTOCHROME P450 2C19; CYTOCHROME P450 3A4; DRUG METABOLITE; HERBACEOUS AGENT; OMEPRAZOLE; OMEPRAZOLE SULFONE; PLACEBO; UNCLASSIFIED DRUG; YIN ZHI HUANG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG HYDROXYLATION; ENZYME SUBSTRATE; GENOTYPE; HERB DRUG INTERACTION; HERBAL MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID; MALE; NORMAL HUMAN; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; ULTRAVIOLET SPECTROSCOPY;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADULT; ANTI-ULCER AGENTS; AREA UNDER CURVE; ARTEMISIA; ARYL HYDROCARBON HYDROXYLASES; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP3A; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; GENOTYPE; HERB-DRUG INTERACTIONS; HUMANS; HYDROXYLATION; MALE; OMEPRAZOLE; PLANTS, MEDICINAL; SAFROLE;

EID: 34848918139     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00617.x     Document Type: Article

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