Alpha 1-antitrypsin and ilomastat inhibit inflammatory proteases present in human middle ear effusions

Laryngoscope

Volumn 113, Issue 8, 2003, Pages 1347-1351

  Antonelli, Patrick J ^a   Schultz, Gregory S ^a   Kim, Karen M ^b   Cantwell, John S ^b   Sundin, David J ^b   Pemberton, Philip A ^b   Barr, Philip J ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b Arriva Pharmaceuticals Inc   (United States)

Author keywords

Alpha 1 antitrypsin; Ilomastat; Otitis media; Protease; Protease inhibitor

Indexed keywords

ALPHA 1 ANTITRYPSIN; ILOMASTAT; LEUKOCYTE ELASTASE; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; PROTEINASE; SERINE PROTEINASE;

ARTICLE; CHRONIC INFLAMMATION; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE EAR EFFUSION; MIDDLE EAR SURGERY; OTITIS MEDIA; OTORRHEA; PATHOGENESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; TYMPANOSTOMY TUBE;

ADOLESCENT; ADULT; ALPHA 1-ANTITRYPSIN; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; HUMANS; INDOLES; INFLAMMATION MEDIATORS; LEUKOCYTE ELASTASE; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; OTITIS MEDIA WITH EFFUSION; OTITIS MEDIA, SUPPURATIVE; RECURRENCE; SERINE PROTEINASE INHIBITORS;

EID: 0041622802     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200308000-00015     Document Type: Article

References (32)

1. Juhn SK, Huff JS. Biochemical characteristics of middle ear effusions. Ann Otol Rhinol Larvngol 1976;85(2 Suppl 25 Pt 2):110-116.
2. Lowell SH, Juhn SK. The role of bacterial enzymes in inducing inflammation in the middle ear cavity. Otolaryngol Head Neck Surg 1979;87:859-870.
3. Plaut AG, Qiu J, St Geme JW III. Human lactoferrin proteolytic activity: analysis of the cleaved region in the IgA protease of Haemophilus influenzae. Vaccine 2000 8;19(Suppl 1):S148-s152.
4. Avidano MA, Cotter CS, Stringer SP, Schultz GS. Analysis of protease activity in human otitis media. Otolaryngol Head Neck Surg 1998;119:346-351.
5. Hamaguchi Y, Sakakura Y. Neutrophil elastase and its complex with alpha 1-antitrypsin in the pathogenesis of chronic suppurative otitis media. Ann Otol Rhinol Laryngol Suppl 1992;157:26-31.
6. Tasker A, Dettmar PW, Panetti M, et al. Reflux of gastric juice and glue ear in children. Lancet 2002;359:493.
7. Heavner SB, Hardy SM, White DR, et al. Function of the eustachian tube after weekly exposure to pepsin/hydrochloric acid. Otolaryngol Head Neck Surg 2001;125:123-129.
8. Brand K. Cancer gene therapy with tissue inhibitors of metalloproteinases (TIMPs). Curr Gene Ther 2002;2:255-271.
9. Wachter AM, Lezdey J. Treatment of atopic dermatitis with alpha 1-proteinase inhibitor. Ann Allergy 1992;69:407-414.
10. Doring G. Serine proteinase inhibitor therapy in alpha(1)antitrypsin inhibitor deficiency and cystic fibrosis. Pediatr Pulmonol 1999;28:363-375.
11. Cotter CS, Avidano MA, Stringer SP, Schultz GS. Inhibition of proteases in Pseudomonas otitis media in chinchillas. Otolaryngol Head Neck Surg 1996;115:342-351.
12. Antonelli PJ, Schultz GS, Sundin DJ, et al. Protease inhibitors alpha 1-antitrypsin and ilomastat are not ototoxic in the chinchilla. Presented at the Association for Research in Otolaryngology Midwinter Meeting, Daytona Beach, February 23-27, 2003. Laryngoscope (in press).
13. Lehman DA, Wilmoth JG, Schultz GS, et al. Inhibition of matrix metalloproteinases in the gerbil model of cholesteatoma. Otolaryngol Head Neck Surg 2002;126:273-280.
14. Weingarten H, Feder J. Spectrophotometric assay for vertebrate collagenase. Anal Biochem 1985;147:437-440.
15. Alpagot T, Silverman S, Lundergran W, et al. Crevicular fluid elastase levels in relation to periodontitis and metabolic control of diabetes. J Periodontal Res 2001;36:169-174.
16. Travis J, Owen M, George P, et al. Isolation and properties of recombinant DNA produced variants of human alproteinase inhibitor. J Biol Chem 1985;260:4384-4389.
17. Woods DE, Cryz SJ, Friedman RL, Iglewski BH. Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats. Infect Immun 1982;36:1223-1228.
18. Sebert ME, Palmer LM, Rosenberg M, Weiser JN. Microarray-based identification of htrA, a Streptococcus pneumoniae gene that is regulated by the CiaRH two-component system and contributes to nasopharyngeal colonization. Infect Immun 2002;70:4059-4067.
19. Scheiblauer H, Reinacher M, Tashiro M, Rott R. Interactions between bacteria and influenza A virus in the development of influenza pneumonia. J Infect Dis 1992;166:783-791.
20. Trengove NJ, Stacey MC, MacAuley S, et al. Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regen 1999;7:442-452.
21. Post JC. Direct. evidence of bacterial biofilms in otitis media. Laryngoscope 2001;111:2083-2094.
22. Hoyle BD, Jass J, Costerton JW. The biofilm glycocalyx as a resistance factor. J Antimicrob Chemother 1990;26:1-5.
23. Miyajima S, Akaike T, Matsumoto K, et al. Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro. Microb Pathog 2001;31:271-281.
24. Jennings CR, Guo L, Collins HM, Birchall JP. Matrix metalloproteinases 2 and 9 in otitis media with effusion. Clin Otolaryngol 2001;26:491-494.
25. Schmidt M, Grunsfelder P, Hoppe F. Up-regulation of matrix metalloprotease-9 in middle ear cholesteatoma-correlations with growth factor expression in vivo? Eur Arch Otorhinolaryngol 2001;258:472-476.
26. Tierney P, Chan B, Samuel D, et al. Neutrophil elastase-alpha 1-antitrypsin in middle ear fluid in chronic otitis media with effusion. Clin Otolaryngol 1995;20:230-233.
27. Carlsson B, Lundberg C, Ohlsson K. Granulocyte protease inhibition in acute and chronic middle ear effusion. Acta Otolaryngol 1983;95:341-349.
28. Galardy RE, Cassabonne ME, et al. Low molecular weight inhibitors in corneal ulceration. Ann N Y Acad Sci 1994;732:315-323.
29. 1-antitrypsin. Am J Resp Crit Care Med 1998;158:49-59.
30. Wencker M, Fuhrmann B, Banik N, Konietzko N. Longitudinal follow-up of patients with α-protease inhibitor deficiency before and during therapy with IV α-protease inhibitor. Chest 2001;119:737-744.
31. Hubbard RC, McElvaney NG, Sellers SE, et al. Recombinant DNA-produced α1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with α1-antitrypsin deficiency. J Clin Invest 1989;84:1349-1354.
32. Stiskal JA, Dunn MS, Shennan AT, et al. Alpha1-proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity: a randomized, controlled trial. Pediatrics 1998;101:89-94.