Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase

Biochemical and Biophysical Research Communications

Volumn 363, Issue 3, 2007, Pages 547-553

  Pillai, Bindu ^a   Cherney, Maia ^a   Diaper, Christopher M ^a   Sutherland, Andrew ^b   Blanchard, John S ^c   Vederas, John C ^a   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Active site mutants; Catalytic mechanism; Crystal structure; DAP epimerase; Domain closure

Indexed keywords

CYSTEINE; DIAMINOPIMELIC ACID; ENZYME INHIBITOR; EPIMERASE; LIGAND; MUTANT PROTEIN; THIOL; THIOL DERIVATIVE; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; ENCAPSULATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HAEMOPHILUS INFLUENZAE; PRIORITY JOURNAL; PROTEIN DOMAIN; SOLVATION;

AMINO ACID ISOMERASES; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; HAEMOPHILUS INFLUENZAE; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE;

EID: 34848903257     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.09.012     Document Type: Article

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