Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1α expression

Stroke

Volumn 38, Issue 10, 2007, Pages 2847-2850

  Kölsch, Heike ^a   Larionov, Sergey ^a   Dedeck, Oliver ^a   Orantes, Mario ^b   Birkenmeier, Gerd ^c   Griffin, W Sue T ^d   Thal, Dietmar Rudolf ^a,e  

^a UNIVERSITY OF BONN   (Germany)

^b Department of Pathology   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^e UNIVERSITY OF ULM   (Germany)

Author keywords

Atherosclerosis; Cerebral arteries; GSTO1 1

Indexed keywords

GLUTATHIONE S TRANSFERASE OMEGA 1; INTERLEUKIN 1ALPHA; TRANSFERASE; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; ATHEROSCLEROTIC PLAQUE; AUTOPSY; BRAIN ATHEROSCLEROSIS; CEREBROVASCULAR DISEASE; DISEASE SEVERITY; ENZYME LOCALIZATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MAJOR CLINICAL STUDY; MULTIINFARCT DEMENTIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; VASCULAR AMYLOIDOSIS;

AGED; AGED, 80 AND OVER; CIRCLE OF WILLIS; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; INTRACRANIAL ARTERIOSCLEROSIS; MIDDLE AGED; POLYMORPHISM, GENETIC; SEVERITY OF ILLNESS INDEX;

EID: 34848898198     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.484162     Document Type: Article

References (7)

1. Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J. Identification, characterization, and crystal structure of the omega class glutathione transferases. J Biol Chem. 2000;275:24798-24806.
2. Kölsch H, Linnebank M, Lütjohann D, Jessen F, Wüllner U, Harbrecht U, Thelen KM, Kreis M, Hentschel F, Schulz A, von Bergmann K, Maier W, Heun R. Polymorphisms in glutathione s-transferase omega-1 and AD, vascular dementia, and stroke. Neurology. 2004;63:2255-2260.
3. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A, Moody DM, O'Brien MD, Yamaguchi T, Grafman J, Drayer BP, Bennett DA, Fisher M, Ogata J, Kokmen E, Bermejo F, Wolf PA, Gorelick PB, Bick KL, Pajeau AK, Bell MA, DeCarli C, Culebras A, Korczyn AD, Bogousslavsky J, Hartmann A, Scheinberg P. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN international workshop. Neurology. 1993;43:250-260.
4. Stary HC. Natural history and histological classification of atherosclerotic lesions: an update. Arterioscler Thromb Vasc Biol. 2000;20:1177-1178.
5. Vonsattel JP, Myers RH, Hedley-Whyte ET, Ropper AH, Bird ED, Richardson EP Jr. Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study. Ann Neurol. 1991;30:637-649.
6. Larionov S, Dedeck O, Birkenmeier G, Thal DR. Expression of alpha(2)-macroglobulin, neutrophil elastase, and interleukin-1alpha differs in early-stage and late-stage atherosclerotic lesions in the arteries of the circle of Willis. Acta Neuropathol (Berl). 2007;113:33- 43.
7. Laliberte RE, Perregaux DG, Hoth LR, Rosner PJ, Jordan CK, Peese KM, Eggler JF, Dombroski MA, Geoghegan KF, Gabel CA. Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing. J Biol Chem. 2003;278:16567-16578.