Ghrelin in vitro modulates vasoactive factors in human umbilical vein endothelial cells

Fertility and Sterility

Volumn 88, Issue 4 SUPPL., 2007, Pages 1158-1166

  Minici, Francesca ^a   Miceli, Fiorella ^a   Tiberi, Federica ^a   Tropea, Anna ^a   Orlando, Mariateresa ^a   Gangale, Maria Francesca ^a   Romani, Federica ^a   Catino, Stefania ^b   Lanzone, Antonio ^b   Apa, Rosanna ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

endothelial cell proliferation; Ghrelin; HUVEC; nitric oxide; prostaglandins

Indexed keywords

BROXURIDINE; CYCLOOXYGENASE 2; GHRELIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN; VASOACTIVE AGENT;

ARTICLE; BLOOD VESSEL TONE; CELL COUNT; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; MEDICAL RESEARCH; MOLECULAR BIOLOGY; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREGNANCY; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RADIOIMMUNOASSAY; RNA EXTRACTION; SUPERNATANT; UMBILICAL CORD; UMBILICAL VEIN;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; PEPTIDE HORMONES; PREGNANCY; UMBILICAL VEINS; VASOMOTOR SYSTEM;

EID: 34848896852     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.01.024     Document Type: Article

References (28)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
2. Smith R.G., Van der Ploeg L.H., Howard A.D., Feighner S.D., Cheng K., Hickey G.J., et al. Peptidomimetic regulation of growth hormone secretion. Endocr Rev 18 (1997) 621-645
3. Howard A.D., Feighner S.D., Cully D.F., Arena J.P., Liberator P.A., Rosenblum C.I., et al. A receptor in pituitary and hypothalamus that functions in growth hosrmone release. Science 273 (1996) 974-977
4. McKee K.K., Palyha O.C., Feighner S.D., Hreniuk D.L., Tan C.P., Phillips M.S., et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Mol Endocrinol 11 (1997) 415-423
5. Guan X.M., Yu H., Palyha O.C., McKee K.K., Feighner S.D., Sirinathsinghji D.J., et al. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 48 (1997) 23-29
6. Papotti M., Ghe C., Cassoni P., Catapano F., Deghenghi R., Ghigo E., et al. Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 85 (2000) 3803-3807
7. Gaytan F., Barreiro M.L., Chopin L.K., Herington A.C., Morales C., Pinilla L., et al. Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. J Clin Endocrinol Metab 88 (2003) 879-887
8. Gnanapavan S., Kola B., Bustin S.A., Morris D.G., McGee P., Fairclough P., et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87 (2002) 2988
9. Tanaka K., Minoura H., Isobe T., Yonaha H., Kawato H., Wang D.F., et al. Ghrelin is involved in the decidualization of human endometrial stromal cells. J Clin Endocrinol Metab 88 (2003) 2335-2340
10. Gualillo O., Caminos J., Blanco M., Garcia-Caballero T., Kojima M., Kangawa K., et al. Ghrelin, a novel placental-derived hormone. Endocrinology 142 (2001) 788-794
11. Cross J.C., Hemberger M., Lu Y., Nozaki T., Whiteley K., Masutani M., et al. Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta. Mol Cell Endocrinol 187 (2002) 207-212
12. Conconi M.T., Nico B., Guidolin D., Baiguera S., Spinazzi R., Rebuffat P., et al. Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo. Peptides 25 (2004) 2179-2185
13. Akarasereenont P., Techatrisak K., Chotewuttakorn S., and Thaworn A. The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin E2 through cAMP. Mediators Inflamm 8 (1999) 287-294
14. Uracz W., Uracz D., Olszanecki R., and Gryglewski R.J. Interleukin 1beta induces functional prostaglandin E synthase in cultured human umbilical vein endothelial cells. J Physiol Pharmacol 53 (2002) 643-654
15. Miceli F., Tropea A., Minici F., Orlando M., Lamanna G., Gangale M.F., et al. Effects of insulin-like growth factor I and II on prostaglandin synthesis and plasminogen activator activity in human umbilical vein endothelial cells. J Clin Endocrinol Metab 90 (2005) 372-378
16. Ciabattoni G., Pugliese F., Spaldi M., Cinotti G.A., and Patrono C. Radioimmunoassay measurement of prostaglandins E2 and F2alpha in human urine. J Endocrinol Invest 2 (1979) 173-182
17. Dennefors B.L., Sjogren A., and Hamberger L. Progesterone and adenosine 3',5'-monophosphate formation by isolated human corpora lutea of different ages: influences of human chorionic gonadotropin and prostaglandins. J Clin Endocrinol Metab 55 (1982) 102-107
18. Zadeh M.S., Kolb J.P., Geromin D., D'Anna R., Boulmerka A., Marconi A., et al. Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase. J Leukoc Biol 67 (2000) 327-334
19. Malaguarnera L., Pilastro M.R., Quan S., Ghattas M.H., Yang L., Mezentsev A.V., et al. Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells. Int J Mol Med 10 (2002) 433-440
20. Loscalzo J., and Welch G. Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis 38 (1995) 87-104
21. Camacho M., Lopez-Belmonte J., and Vila L. Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity. Circ Res 83 (1998) 353-365
22. Haugen G., and Helland I. Influence of preeclampsia or maternal intake of omega-3 fatty acids on the vasoactive effect of prostaglandin F-two-alpha in human umbilical arteries. Gynecol Obstet Invest 52 (2001) 75-81
23. Campbell W.B., and Halushka P.V. Eicosanoids and platelet-activating factor. In: Hardman J.G., Limbird L.E., Molinoff P.M., Ruddon R.W., and Gilman A.G. (Eds). Goodman and Gilman's the pharmacologic basis of therapeutic (1996), McGraw-Hill, New York 601
24. Farquhar J., Heiman M., Wong A.C., Wach R., Chessex P., and Chanoine J.P. Elevated umbilical cord ghrelin concentrations in small for gestational age neonates. J Clin Endocrinol Metab 88 (2003) 4324-4327
25. Makino Y., Hosoda H., Shibata K., Makino I., Kojima M., Kangawa K., et al. Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy. Hypertension 39 (2002) 781-784
26. Mazzocchi G., Neri G., Rucinski M., Rebuffat P., Spinazzi R., Malendowicz L.K., et al. Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects. Peptides 25 (2004) 1269-1277
27. Cassoni P., Papotti M., Ghe C., Catapano F., Sapino A., Graziani A., et al. Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab 86 (2001) 1738-1745
28. Dolbeare F. Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part III. Proliferation in normal, injured and diseased tissue, growth factors, differentiation, DNA replication sites and in situ hybridization. Histochem J 28 (1996) 531-575