High-resolution oligonucleotide array-CGH pinpoints genes involved in cryptic losses in chronic lymphocytic leukemia

Cytogenetic and Genome Research

Volumn 118, Issue 1, 2007, Pages 8-12

  Tyybakinoja A ^a   Vilpo, J ^b   Knuutila, S ^a,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTIC METHOD; ARTICLE; ATM GENE; CHROMOSOME 11Q; CHROMOSOME 13Q; CHRONIC LYMPHATIC LEUKEMIA; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DLEU1 GENE; DLEU2 GENE; DNA MICROARRAY; FAM10A4 GENE; GENE; GENE DELETION; GENE IDENTIFICATION; GENETIC ANALYSIS; GENOMICS; HUMAN; KCNRG GENE; MIRN15A GENE; MIRN16-1 GENE; PRIORITY JOURNAL; TRIM13 GENE;

CHROMOSOME ABERRATIONS; COHORT STUDIES; GENE DELETION; HUMANS; KARYOTYPING; LEUKEMIA, LYMPHOCYTIC, CHRONIC; NUCLEIC ACID HYBRIDIZATION;

EID: 34848865991     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000106435     Document Type: Article

References (41)

1. Auer RL, Jones C, Mullenbach RA, Syndercombe-Court D, Milligan DW, et al: Role for CCG-trinucleotide repeats in the pathogenesis of chronic lymphocytic leukemia. Blood 97:509-515 (2001).
2. Bea S, Lopez-Guillermo A, Ribas M, Puig X, Pinyol M, et al: Genetic imbalances in progressed B-cell chronic lymphocytic leukemia and transformed large-cell lymphoma (Richter's syndrome). Am J Pathol 161:957-968 (2002).
3. Bullrich F, Veronese ML, Kitada S, Jurlander J, Caligiuri MA, et al: Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia. Blood 88:3109-3115 (1996).
4. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, et al: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99:15524-15529 (2002).
5. Chen L, Widhopf G, Huynh L, Rassenti L, Rai KR, et al: Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 100:4609-4614 (2002).
6. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, et al: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102:13944-13949 (2005).
7. Corcoran MM, Rasool O, Liu Y, Iyengar A, Grander D, et al: Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia. Blood 91:1382-1390 (1998).
8. Corcoran MM, Hammarsund M, Zhu C, Lerner M, Kapanadze B, et al: DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse. Genes Chromosomes Cancer 40:285-297 (2004).
9. Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, et al: Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94:1840-1847 (1999).
10. de Leeuw RJ, Davies JJ, Rosenwald A, Bebb G, Gascoyne RD, et al: Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes. Hum Mol Genet 13:1827-1837 (2004).
11. Döhner H, Stilgenbauer S, James MR, Benner A, Weilguni T, et al: 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 89:2516-2522 (1997).
12. Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, et al: Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343:1910-1916 (2000).
13. Fenaux P, Preudhomme C, Lai JL, Quiquandon I, Jonveaux P, et al: Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis. Leukemia 6:246-250 (1992).
14. Gaidano G, Ballerini P, Gong JZ, Inghirami G, Neri A, et al: p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci USA 88:5413-5417 (1991).
15. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK: Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94:1848-1854 (1999).
16. Ji L, Minna JD, Roth JA: 3p21.3 tumor suppressor cluster: prospects for translational applications. Future Oncol 1:79-92 (2005).
17. Karhu R, Tobin G, Thunberg U, Vilpo L, Sundström C, et al: More extensive genetic alterations in unmutated than in hypermutated cases of chronic lymphocytic leukemia. Genes Chromosomes Cancer 37:417-420 (2003).
18. Knuutila S, Elonen E, Teerenhovi L, Rossi L, Leskinen R, et al: Trisomy 12 in B cells of patients with B-cell chronic lymphocytic leukemia. N Engl J Med 314:865-869 (1986).
19. Knuutila S, Autio K, Aalto Y: Online access to CGH data of DNA sequence copy number changes. Am J Pathol 157:689 (2000).
20. Kohlhammer H, Schwaenen C, Wessendorf S, Holzmann K, Kestler HA, et al: Genomic DNA-chip hybridization in t(11; 14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions. Blood 104:795-801 (2004).
21. Koski T, Karhu R, Visakorpi T, Vilpo L, Knuutila S, Vilpo J: Complex chromosomal aberrations in chronic lymphocytic leukemia are associated with cellular drug and irradiation resistance. Eur J Haematol 65:32-39 (2000).
22. Kröber A, Seiler T, Benner A, Bullinger L, Bruckle E, et al: V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 100:1410-1416 (2002).
23. Kuppers R: Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 5:251-262 (2005).
24. La Starza R, Barba G, Matteucci C, Crescenzi B, Romoli S, et al: Chronic lymphocytic leukaemia. Is terminal del(14)(q24) a new marker for prognostic stratification? Leuk Res 30:1569-1572 (2006).
25. Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, et al: Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. Oncogene 15:2463-2473 (1997).
26. Monni O, Knuutila S: 11q deletions in hematological malignancies. Leuk Lymphoma 40:259-266 (2001).
27. Oscier DG, Thompsett A, Zhu D, Stevenson FK: Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. Blood 89:4153-4160 (1997).
28. Oscier DG, Gardiner AC, Mould SJ, Glide S, Davis ZA, et al: Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood 100:1177-1184 (2002).
29. Ottaggio L, Viaggi S, Zunino A, Zupo S, Rossi E, et al: Chromosome aberrations evaluated by comparative genomic hybridization in B-cell chronic lymphocytic leukemia: correlation with CD38 expression. Haematologica 88:769-777 (2003).
30. Pfeifer D, Pantic M, Skatulla I, Rawluk J, Kreutz C, et al: Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood 109:1202-1210 (2007).
31. Pinkel D, Segraves R, Sudar D, Clark S, Poole I, et al: High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 20:207-211 (1998).
32. Pollack JR, Perou CM, Alizadeh AA, Eisen MB, Pergamenschikov A, et al: Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet 23:41-46 (1999).
33. Rubio-Moscardo F, Climent J, Siebert R, Piris MA, Martin-Subero JI, et al: Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome. Blood 105:4445-4454 (2005).
34. Sankar M, Tanaka K, Kumaravel TS, Arif M, Shintani T, et al: Identification of a commonly deleted region at 17p13.3 in leukemia and lymphoma associated with 17p abnormality. Leukemia 12:510-516 (1998).
35. Schaffner C, Stilgenbauer S, Rappold GA, Döhner H, Lichter P: Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. Blood 94:748-753 (1999).
36. Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, et al: Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 101:1039-1044 (2004).
37. Seiler T, Döhner H, Stilgenbauer S: Risk stratification in chronic lymphocytic leukemia. Semin Oncol 33:186-194 (2006).
38. Stankovic T, Weber P, Stewart G, Bedenham T, Murray J, et al: Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet 353:26-29 (1999).
39. Stilgenbauer S, Liebisch P, James MR, Schröder M, Schlegelberger B, et al: Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-q23.1 in lymphoproliferative disorders. Proc Natl Acad Sci USA 93:11837-11841 (1996).
40. Tyybäkinoja A, Saarinen-Pihkala U, Elonen E, Knuutila S: Amplified, lost, and fused genes in 11q23-25 amplicon in acute myeloid leukemia, an array-CGH study. Genes Chromosomes Cancer 45:257-264 (2006).
41. Zhu Y, Monni O, El-Rifai W, Siitonen SM, Vilpo L, et al: Discontinuous deletions at 11q23 in B cell chronic lymphocytic leukemia. Leukemia 13:708-712 (1999).