Androgen receptor co-activator Hic-5/ARA55 as a molecular regulator of androgen sensitivity in dermal papilla cells of human hair follicles

Journal of Investigative Dermatology

Volumn 127, Issue 10, 2007, Pages 2302-2306

  Inui, Shigeki ^a   Fukuzato, Yoko ^a   Nakajima, Takeshi ^a   Kurata, Sotaro ^a   Itami, Satoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ASSOCIATED PROTEIN 55; LUCIFERASE; METRIBOLONE; UNCLASSIFIED DRUG; ANDROGEN; MESSENGER RNA; SIGNAL PEPTIDE; TGFB1I1 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ALOPECIA; ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; GENE EXPRESSION; HAIR FOLLICLE; HAIR GROWTH; HORMONAL REGULATION; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; MALE; MOUSE MAMMARY TUMOR ONCOVIRUS; OCCIPITAL BONE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCALP HAIR; SKIN CELL; TRANSACTIVATION; CELL CULTURE; CYTOLOGY; FACE; GENETIC TRANSFECTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAIR; METABOLISM; PHYSIOLOGY; SCALP;

ADOLESCENT; ADULT; ANDROGENS; CELLS, CULTURED; FACE; HAIR; HAIR FOLLICLE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAMMARY TUMOR VIRUS, MOUSE; RECEPTORS, ANDROGEN; RNA, MESSENGER; SCALP; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 34848863643     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700883     Document Type: Article

References (26)

1. Foitzik K, Lindner G, Mueller-Roever S, Maurer M, Botchkareva N, Botchkarev V et al. (2000) Control of murine hair follicle regression (catagen) by TGF-β1 in vivo. FASEB J 14:752-60
2. Fujimoto N, Mizokami A, Harada S, Matsumoto T (2001) Different expression of androgen receptor coactivators in human prostate. Urology 58:289-94
3. Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A et al. (1999) Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. J Biol Chem 274:8316-21
4. Hamada K, Randall VA (2006) Inhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldness. Br J Dermatol 154:609-18
5. Hamada K, Thornton MJ, Laing I, Messenger AG, Randall VA (1996) The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles concurs with hair growth in 5 α-reductase deficiency. J Invest Dermatol 106:1017-22
6. Heinlein CA, Chang C (2002) Androgen receptor (AR) coregulators: an overview. Endocr Rev 23:175-200
7. Hibberts NA, Howell AE, Randall VA (1998) Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp. J Endocrinol 156:59-65
8. Hibino T, Nishiyama T (2004) Role of TGF-β2 in the human hair cycle. J Dermatol Sci 35:9-18
9. Inui S, Fukuzato Y, Nakajima T, Yoshikawa K, Itami S (2002) Androgen-inducible TGF-β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understand paradoxical effects of androgen on human hair growth. FASEB J 16:1967-9
10. Itami S, Kurata S, Sonoda T, Takayasu S (1991) Characterization of 5 α-reductase in cultured human dermal papilla cells from beard and occipital scalp hair. J Invest Dermatol 96:57-60
11. Itami S, Kurata S, Sonoda T, Takayasu S (1995a) Interaction between dermal papilla cells and follicular epithelial cells in vitro. Br J Dermatol 132:527-32
12. Itami S, Kurata S, Takayasu S (1990) 5 α-Reductase activity in cultured human dermal papilla cells from beard compared with reticular dermal fibroblasts. J Invest Dermatol 94:150-2
13. Itami S, Kurata S, Takayasu S (1995b) Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor-I from dermal papilla cells. Biochem Biophys Res Commun 212:988-94
14. Lee P, Zhu CC, Sadick NS, Diwan AH, Zhang PS, Liu JS et al. (2005) Expression of androgen receptor coactivator ARA70/ELE1 in androgenic alopecia. J Cutan Pathol 32:567-71
15. Mestayer C, Blanchere M, Jaubert F, Dufour B, Mowszowicz I (2003) Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines. Prostate 56:192-200
16. Miyamoto H, Rahman MM, Chang C (2004) Molecular basis for the antiandrogen withdrawal syndrome. J Cell Biochem 91:3-12
17. Miyoshi Y, Ishiguro H, Uemura H, Fujinami K, Miyamoto H, Miyoshi Y et al. (2003) Expression of AR associated protein 55 (ARA55) and androgen receptor in prostate cancer. Prostate 56:280-6
18. Rahman MM, Miyamoto H, Lardy H, Chang C (2003) Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells. Proc Natl Acad Sci USA 100:5124-429
19. Randall VA, Hibberts NA, Thornton MJ, Hamada K, Merrick AE, Kato S et al. (2000) The hair follicle: a paradoxical androgen target organ. Horm Res 54:243-50
20. Randall VA, Thornton MJ, Messenger AG (1992) Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp. J Endocrinol 133:141-7
21. Shapiro J, Price VH (1998) Hair regrowth. Therapeutic agents. Dermatol Clin 16:341-56
22. Shibanuma M, Mashimo J, Kuroki T, Nose K (1994) Characterization of the TGF-β1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence. J Biol Chem 269:26767-74
23. Shibanuma M, Mori K, Kim-Kaneyama JR, Nose K (2005) Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM Protein, Hic-5. Antioxid Redox Signal 7:335-47
24. Soma T, Tsuji Y, Hibino T (2002) Involvement of transforming growth factor-β2 in catagen induction during the human hair cycle. J Invest Dermatol 118:993-7
25. Thornton MJ, Laing I, Hamada K, Messenger AG, Randall VA (1993) Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells. Clin Endocrinol (Oxford) 39:633-9
26. Thornton MJ, Messenger AG, Elliott K, Randall VA (1991) Effect of androgens on the growth of cultured human dermal papilla cells derived from beard and scalp hair follicles. J Invest Dermatol 97:345-8