Induction of detoxifying enzyme by sesquiterpenes present in Inula helenium

Journal of Medicinal Food

Volumn 10, Issue 3, 2007, Pages 503-510

  Sun, Seong Im ^a   Ju, Ryoung Kim ^b   Hyun, Ae Lim ^b   Chan, Ho Jang ^b   Young, Kyoon Kim ^c   Konishi, T ^d   Eun, Ji Kim ^a   Park, Jung Han Yoon ^a   Kim, Jong Sang ^b  

^a Hallym University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Kookmin University   (South Korea)

^d KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

5 epoxyalantolactone; Alantolactone; Cancer prevention; Inula helenium; Isoalantolactone; Quinone reductase; Sesquiterpenes

Indexed keywords

5ALPHA EPOXYALANTOLACTONE; ALANTOLACTONE; BUTANOL; DICHLOROMETHANE; GLUTATHIONE TRANSFERASE; HEXANE; INULA HELENIUM EXTRACT; ISOALANTOLACTONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER PREVENTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECAMPANE; ENZYME INDUCTION; HUMAN; HUMAN CELL; INULA; KIDNEY; LIVER; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; STOMACH; XENOBIOTIC METABOLISM;

ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENE EXPRESSION; GLUTATHIONE TRANSFERASE; HEXANES; HUMANS; INJECTIONS, INTRAPERITONEAL; INULA; LUCIFERASES; MALE; METABOLIC DETOXICATION, PHASE II; MICE; MICE, INBRED ICR; NAD(P)H DEHYDROGENASE (QUINONE); PLANT EXTRACTS; RESPONSE ELEMENTS; SESQUITERPENES; TRANSFECTION;

INULA HELENIUM; MUS;

EID: 34848862772     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2006.209     Document Type: Article

References (22)

1. Steele VE, Kelloff GJ: Development of cancer chemopreventive drugs based on mechanistic approaches. Mutat Res 2005;591:16-23.
2. Talalay P, Dinkova-Kostova AT: Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates. Methods Enzymol 2004;382:355-364.
3. Jaiswal AK: Regulation of genes encoding NAD(P)H:quinone oxidoreductases. Free Radic Biol Med 2000;29:254-262.
4. Kim JH, Lee JS, Song KS, Kwon CS, Kim YK, Kim JS: Polyozellin isolated from Polyozellus multiplex induces phase 2 enzymes in mouse hepatoma cells and differentiation in human myeloid leukaemic cell lines. J Agric Food Chem 2004;52:451-455.
5. Li J, Lee J-M, Johnson DA, Johnson J: Antioxidant response element activation by quinones: antioxidant response element target genes, role of PI3 kinase in activation. Methods Enzymol 2004;378:238-258.
6. Jeong WS, Jun M, Kong AN: Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxid Redox Signal 2006;8:99-106.
7. Kwon CS, Kim JH, Son KH, Kim YK, Lee JS, Lim JK, Kim JS: Induction of quinone reductase, an anticarcinogenic marker enzyme, by medicinal herb extracts. Nutraceut Food 2002;7:358-366.
8. Chevallier A: Encylopedia of Medicinal Plants: a Practical Reference Guide to More than 550 Key Medicinal Plants and Their Use, Dorling Kindersley, London, 2001, p. 109.
9. Konishi T, Shimada Y, Nagao T, Okabe H, Konoshima T: Antiproliferative sesquiterpene lactones from the roots of Inula helenium. Biol Pharm Bull 2002;25:1370-1372.
10. Kim BR, Hu R, Keum YS, Hebbar V, Shen G, Nair SS, Kong AN: Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Res 2003;63:7520-7525.
11. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
12. Benson AM, Hunkeler MJ, Talalay P: Increase of NAD(P)H: quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc Natl Acad Sci U S A 1980;77:5216-5220.
13. Habig WH, Pabst MJ, Jakoby WB: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-7139.
14. Anderson ME: Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 1985;113:548-555.
15. De Long MJ, Dolan P, Santamaria AB, Bueding E: 1,2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells. Carcinogenesis 1986;7:977-980.
16. Dinkova-Kostova AT, Fahey JW, Talalay P: Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1). Methods Enzymol 2004;382:423-448.
17. Herrera F, Martin V, Rodriguez-Bianco J, Garcia-Santos G, Antolin I, Rodriguez C: Intracellular redox state regulation by parthenolide. Biochem Biophys Res Commun 2005;332:321-325.
18. Tudor G, Alley M, Nelson CM, Huang R, Covell DG, Gutierrez P, Sausville EA: Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction. Anticancer Drugs 2005;16:381-391.
19. Wen J, You K-R, Lee S-Y, Song C-H, Kim D-G: Oxidative stress-mediated apoptosis - the anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem 2002;277:38954-38964.
20. Iskander K, Jaiswal AK: Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity. Chem Biol Interact 2005;153-154:147-157.
21. Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, Kerns ML, Talalay P: Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. Cancer Epidemiol Biomarkers Prev 2007;16:847-851.
22. Tanii H, Higashi T, Nishimura F, Higuchi Y, Saijoh K: Induction of detoxication enzymes in mice by naturally occurring allyl nitrile. J Agric Food Chem 2005;53:8993-8996.