Unlike ghrelin, obestatin does not exert any relevant activity in chondrocytes [2]

Annals of the Rheumatic Diseases

Volumn 66, Issue 10, 2007, Pages 1399-1400

  Lago, Rocio ^a   Gomez, Rodolfo ^a   Dieguez, Carlos ^b   Gomez Reino, Juan J ^a   Lago, Francisca ^a   Gualillo, Oreste ^a  

^a Instituto de Salud Carlos III   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINO ACID; GHRELIN; OBESTATIN; UNCLASSIFIED DRUG;

BONE METABOLISM; CARTILAGE CELL; CELL ACTIVITY; CELL METABOLISM; ENZYME IMMUNOASSAY; LETTER; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

ANIMALS; CELL CYCLE; CELLS, CULTURED; CHONDROCYTES; MICE; PEPTIDE HORMONES;

EID: 34848843550     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2006.068155     Document Type: Letter

References (9)

1. Zang JV, Ren EG, Avsian-Kretchmer O, et al. Obestatin a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005;310:996-9.
2. Gualillo O, Lago F, Casanueva FF, Dieguez C. One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects. Mol Cell Endocrinol 2006;256:1-8.
3. Caminos JE, Gualillo O, Lago F, et al. The endogenous growth hormone secretogogue (Ghrelin) is synthesized and secreted by chondrocytes. Endocrinology 2005;146:1285-9.
4. Karsenty G. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab 2006;4:341-8.
5. Otero M, Lago R, Gomez R, et al. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 2006;65:1198-201.
6. Kim SW, Her SJ, Park SJ, et al. Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoclastic MC3T3-E1 cells. Bone 2005;37:359-69.
7. Fukushima N, Hanada R, Teranishi H, et al. Ghrelin directly regulates bone formation. J Bone Miner Res 2005;20:790-8.
8. Thomas DP, Sunters A, Gentry A, Grigoriadis AE. Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene. J Cell Sci 2000;113:439-50.
9. Finger F, Schorle C, Zien A, et al. Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, andC-28/12. Arthritis Rheum 2003;48:3395-403.