Family Flexiviridae: A case study in virion and genome plasticity

Annual Review of Phytopathology

Volumn 45, Issue , 2008, Pages 73-100

  Martelli, Giovanni P ^a   Adams, Michael J ^b   Kreuze, Jan F ^c,d   Dolja, Valerian V ^e  

^a UNIVERSITY OF BARI   (Italy)

^b ROTHAMSTED RESEARCH   (United Kingdom)

^c INTERNATIONAL POTATO CENTER   (Peru)

^d SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^e OREGON STATE UNIVERSITY   (United States)

Author keywords

Comparative genomics; Evolution; Phylogeny; Positive strand RNA viruses; Taxonomy

Indexed keywords

ALLEXIVIRUS; CAPILLOVIRUS; CARLAVIRUS; FLEXIVIRIDAE; FOVEAVIRUS; MANDARIVIRUS; POTEXVIRUS; RNA VIRUSES; TRICHOVIRUS; TYMOVIRIDAE; VITIVIRUS;

VIRUS PROTEIN;

CLASSIFICATION; FLEXIVIRIDAE; GENETICS; MOLECULAR EVOLUTION; PATHOGENICITY; PHYLOGENY; PHYSIOLOGY; PLANT DISEASE; REVIEW; RNA VIRUS; ULTRASTRUCTURE; VIRION; VIROLOGY; VIRUS GENOME;

EVOLUTION, MOLECULAR; FLEXIVIRIDAE; GENOME, VIRAL; PHYLOGENY; PLANT DISEASES; RNA VIRUSES; VIRAL PROTEINS; VIRION;

EID: 34848823671     PISSN: 00664286     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.phyto.45.062806.094401     Document Type: Review

References (129)

1. Aas PA, Otterlei M, Falnes PO, Vagbo CB, Skorpen F, et al. 2003. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature 421:859-63
2. Adams MJ, Accotto GP, Agranovsky AA, Bar-Joseph M, Boscia D, et al. 2005. Family Flexiviridae. In Virus Taxonomy. Eighth Rep. Int. Comm. Taxon. Viruses, ed. CM Fauquet, MA Mayo, J Maniloff, U Desselberger, LA Ball, pp. 1089-124. Amsterdam: Elsevier/Academic
3. Ahlquist P. 2006. Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses. Nat. Rev. Microbiol. 4:371-82
4. Ahmed N, Christie S, Zettler F. 1983. Identification and partial characterization of a closterovirus infecting Nandina domestica. Phytopathology 73:470-75
5. Aravind L, Koonin EV. 2001. The DNA repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol. 2(3):research007.1-research0007.8
6. Barg E, Lesemann DE, Vetten HJ, Green SK. 1994. Identification, partial characterization and distribution of viruses infecting allium crops in south and south-east Asian countries. Acta Hortic. 358:251-58
7. Batten JS, Yoshinari S, Hemnway C. 2003. Potato virus X: a model system for virus replication, movement and gene expression. Mol. Plant Pathol. 4:125-31
8. Bayne EH, Rakitina DV, Morozov SY, Baulcombe DC. 2005. Cell-to-cell movement of potato potexvirus X is dependent on suppression of RNA silencing. Plant J. 44:471-82
9. Benson SD, Bamford JKH, Bamford DH, Burnett RM. 2004. Does common architecture reveal a viral lineage spanning all three domains of life? Mol. Cell 16:673-85
10. Bonavia M, Digiaro M, Boscia D, Boari A, Bottalico G, et al. 1996. Studies on "corky rugose wood" of grapevine and the diagnosis of grapevine virus B. Vitis 35:53-58
11. Boscia D, Savino V, Minafra A, Namba S, Elicio V, et al. 1993. Properties of a filamentous virus isolated from grapevines affected by corky bark. Arch. Virol. 130:109-20
12. Boscia D, Minafra A, Martelli GP. 1997. Filamentous viruses of the grapevine: putative trichoviruses and capilloviruses. See Ref. 87a, pp. 19-28
13. Bratlie MS, Drabløs F. 2005. Bioinformatic mapping of AlkB homology domains in viruses. BMC Genomics 6:1-15, doi:10.1186/1471-2164- 6-1
14. Brigneti G, Voinnet O, Li WX, Ji LH, Ding SW, et al. 1998. Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana. EMBO J. 17:6739-46
15. Brunt AA. 1978. The occurrence, hosts and properties of lilac chlorotic leafspot virus, a newly recognized virus from Syringa vulgaris. Ann. Appl. Biol. 88:383-91
16. Brunt AA, Stace Smith R. 1978. The intracellular location of lilac chlorotic leafspot virus. J. Gen. Virol. 39:63-71
17. Brunt AA, Crabtree K, Dallwitz MJ, Gibbs AJ, Watson L, eds. 1996. Viruses of Plants. Descriptions and Lists from the VIDE Database. Wallingford, UK: CAB Int. 1484 pp.
18. Byadgi AS, Ahlawat YS, Chakraborty NK, Varma A, Srivastava M, et al. 1993. Characterization of a filamentous virus associated with citrus ringspot in India. Proc. Conf. Int. Org. Citrus Virol., 12th, Riverside, pp. 184-87
19. Callaway A, Giesman-Cookmeyer D, Gillock ET, Sit TL, Lommel SA. 2001. The multifunctional capsid proteins of plant RNA viruses. Annu. Rev. Phytopathol. 39:419-60
20. Chiba M, Reed JC, Prokhnevsky AI, Chapman EJ, Mawassi M, et al. 2006. Diverse suppressors of RNA silencing enhance agroinfection by a viral replicon. Virology 346:7-14
21. Cheng JH, Peng CW, Hsu YH, Tsai CH. 2002. The synthesis of minus-strand RNA of Bamboo mosaic potexvirus initiates from multiple sites within the poly(A) tail. J. Virol. 76:6114-20
22. Chevalier S, Greif C, Clauzel JM, Walter B, Fritsch C. 1995. Use of an immunocapture-polymerase chain reaction procedure for the detection of grapevine virus A in Kober stem grooving-infected grapevines. J. Phytopathol. 143:368-73
23. Christie RG, Edwardon JR. 1977. Light and electron microscopy of plant virus inclusions. Fla. Agric. Exp. Stn. Monogr. Ser. No 9, 155 pp.
24. Claverie JM. 2006. Viruses take center stage in cellular evolution. Genome Biol. 7(6):110
25. Culley AI, Lang AS, Suttle CA. 2006. Metagenomic analysis of coastal RNA virus communities. Science 312:1795-98
26. Davenport GF, Baulcombe DC. 1997. Mutation of the GKS motif of the RNA-dependent RNA polymerase from potato virus X disables or eliminates virus replication. J. Gen. Virol. 78:1247-51
27. Desvignes JC, Boyé R, Cornaggia D, Grasseau N. 1999. Maladies à Virus des Arbres Fruitiers. Paris: Cent. Tech. Interprof. Fruits Legumes. 202 pp.
28. Dolja VV. 2003. Beet yellows virus: the importance of being different. Mol. Plant Pathol. 4:91-98
29. Dolja W, Boyko VP, Agranovsky AA, Koonin EV. 1991. Phylogeny of capsid proteins of rod-shaped and filamentous RNA plant viruses: two families with distinct patterns of sequence and probably structure conservation. Virology 184:79-86
30. Dolja W, Grama DP, Morozov SY, Atabekov JG. 1987. Potato virus X-related single-and double-stranded RNAs. FEBS Lett. 214:308-12
31. Dolja W, Kreuze JF, Valkonen JPT. 2006. Comparative and functional genomics of closteroviruses. Virus Res. 117:38-51
32. Dreher TW. 1999. Functions of the 3′-untranslated regions of positive strand RNA viral genomes. Annu. Rev. Phytopathol. 37:151-74
33. Falk BW, Duffus JE. 1988. Ecology and control. See Ref. 86, 4:275-96
34. Faoro F. 1997. Cytopathology of closteroviruses and trichoviruses infecting grapevines. See Ref. 87a, pp. 29-47
35. Forterre P. 2006. The origin of viruses and their possible roles in major evolutionary transitions. Virus Res. 117:5-16
36. Galiakparov N, Goszczynski DE, Che X, Batuman O, Bar-Joseph M, et al. 2003. Two classes of subgenomic RNA of Grapevine virus A produced by internal controller elements. Virology 312:434-48
37. Galiakparov N, Tanne E, Mawassi M, Gafny R, Sela I. 2003. ORF 5 of grapevine virus A encodes a nucleic acid-binding protein and affects pathogenesis. Virus Genes 27:257-62
38. Galiakparov N, Tanne E, Sela I, Gafny R. 2003. Functional analysis of the grapevine virus A genome. Virology 306:42-50
39. Galipienso L, Vives MC, Moreno P, Milne RG, Navarro L, et al. 2001. Partial characterization of citrus leafblotch virus, a new virus from Nagami kumquat. Arch. Virol. 146:357-68
40. Gambley CF, Thomas JE. 2001. Molecular characterization of Banana mild mosaic virus, a new filamentous virus in Musa spp. Arch. Virol. 146:1369-79
41. Garau R, Prota VA, Piredda R, Boscia D, Prota U. 1994. On the possible relationship between Kober stem grooving and grapevine virus A. Vitis 33:161-63
42. Gentit P, Foissac X, Svanella-Dumas L, Candresse T. 2001. Variants of Apricot latent foveavirus (ALV) isolated from south European orchards associated with peach asteroid spot and peach sooty ringspot diseases. Acta Hortic. 550:213-20
43. Goldbach R. 1987. Genome similarities between plant and animal RNA viruses. Microbiol. Sci. 4:197-202
44. Gorbalenya AE, Koonin EV. 1993. Helicases: amino acid sequence comparisons and structure-function relationship. Curr. Opin. Struct. Biol. 3:419-29
45. Goszczynski DE, Joste AEC. 2003. Identification of divergent variants ofGrapevine virus A. Eur. J. Plant Pathol. 109:397-403
46. Goszczynski DE. 2006. Molecular variants of Grapevine virus A (GVA) associated with Shiraz disease in South Africa. Extended Abstr. 15th Meet. ICVG, Stellenbosch, pp. 72-73
47. Gramstat A, Courtpozanis A, Rohde W. 1990. The 12 kDa protein of potato virus M displays properties of a nucleic acid-binding regulatory protein. FEBS Lett. 276:34-38
48. Hadidi A, Khetarpal RK, Koganezawa H, eds. 1998. Plant Virus Disease Control. St. Paul, MN: APS Press
49. Halgren A, Tzanetakis IE, Martin RR. 2007. Identification, characterization and detection of Black raspberry necrosis virus. Phytopathology 97:44-50
50. Haviv S, Goszczynski DE, Mawassi M. 2006. The p10 of Grapevine virus A affects pathogenicity on Nicotiana benthamiana plants. Extended Abstr. 15th Meet. ICVG, Stellenbosch, pp. 69-71
51. Howitt RLJ, Beever RE, Pearson MN, Forster RLS. 2001. Genome characterization of Botrytis virus F, a flexuous rod-shaped mycovirus resembling plant 'potex-like' viruses. J. Gen. Virol. 82:67-78
52. Howitt RL, Beever RE, Pearson MN, Forster RL. 2006. Genome characterization of a flexuous rod-shaped mycovirus, Botrytis virus X, reveals high amino acid identity to genes from plant 'potex-like' viruses. Arch. Virol. 151:563-79
53. Huang YL, Han YT, Chang YT, Hsu YH, Meng M. 2004. Critical residues for GTP methylation and formation of the covalent m7GMP-enzyme intermediate in the capping enzyme domain of Bamboo mosaic virus. J. Virol. 78:1271-80
54. James D, Varga H, Croft H, Rast H, Thompson D, et al. 2006. Molecular characterization, phylogenetic relationships, and specific detection of Peach mosaic virus. Phytopathology 96:137-44
55. Jelkmann W. 1997. Apple stem pitting virus. See Ref. 87a, pp. 133-42
56. Kamer G, Argos P. 1984. Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses. Nucleic Acids Res. 12:7269-82
57. Karpova OV, Zayakina OV, Arkhipenko MV, Sheval EV, Kiselyova OI, et al. 2006. Potato virus X RNA-mediated assembly of single-tailed ternary coat protein-RNA-movement protein complexes. J. Gen. Virol. 87:2731-40
58. Keifer HH, Wilson NS. 1955. A new species of eriophyd mite responsible for the vection of peach mosaic virus. Bull. Calif. Dep. Agric. 44:145-46
59. Koenig R. 1982. Carlavirus group. CMI/AAB Descriptions of Plant Viruses, No. 259
60. Koonin EV, Dolja VV. 1993. Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences. Crit. Rev. Biochem. Mol. Biol. 28:375-430
61. Koonin EV, Dolja VV. 2006. Evolution of complexity in the viral world: the dawn of a new vision. Virus Res. 117:1-4
62. Koonin EV, Senkevich TG, Dolja VV. 2006. The ancient virus world and evolution of cells. Biol. Direct 1:1-27, doi:10.1186/1745-6150-1-29
63. Kumar S, Tamura K, Nei M. 2004. MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment. Briefings Bioinform. 5:150-63
64. Kunugi Y, Asari S, Terai Y, Shinkai A. 2000. Studies on the grapevine berry inner necrosis virus disease. 2. Transmission of berry inner necrosis virus by the grape erineum mite Colomerus vitis in Yamanashi. Bull. Yamanashi Fruit Tree Exp. Stn. 10:57-63
65. Kurstak E, ed. 1981. Handbook of Plant Virus Infections and Comparative Diagnosis. Amsterdam: Elsevier/North Holland
66. Lang AS, Culley AI, Suttle CA. 2004. Genome sequence and characterization of a virus (HaRNAV) related to picorna-like viruses that infects the marine toxic bloom-forming alga Heterosigma akashiwo. Virology 320:206-17
67. La Notte P, Buzkan N, Choueiri E, Minafra A, Martelli GP. 1997. Acquisition and transmission of Grapevine virus A by the mealybug Pseudococcus longispinus. J. Plant Pathol. 79:79-85
68. Larsen HJ, Oldfield GN. 1995. Peach mosaic. In Compendium of Stone Fruits Diseases, ed. JM Ogawa, EI Zher, GW Bird, DF Ritchie, K Uriu, et al, pp. 67-68. St. Paul, MN. APS Press
69. Lawrence DM, Rozanov MN, Hillman BI. 1995. Autocatalytic processing of the 223-kDa protein of blueberry scorch carlavirus by a papain-like proteinase. Virology 207:127-35
70. Lazarovitz SG, Beachy RN. 1999. Viral movement proteins as probes for intracellular and intercellular trafficking in plants. Plant Cell 11:535-48
71. Lesemann DE. 1988. Cytopathology. See Ref. 86, 4:179-235
72. Li YI, Shih TW, Hsu YH, Han YT, Huang YL, et al. 2001. The helicase-like domain of plant potexvirus replicase participates in formation of RNA 5′ cap structure by exhibiting RNA -triphosphatase activity. J. Virol. 75:12114-20
73. Lu R, Folimonov AS, Shintaku M, Li WX, Falk BW. 2004. Three distinct suppressors of RNA silencing encoded by a 20-kb viral RNA genome. Proc. Natl. Acad. Sci. USA 101:15742-47
74. Magome H, Terauchi H, Yoshikawa N, Takahashi T. 1997. Analysis of double-stranded RNA in tissues infected with apple stem grooving capillovirus. Ann. Phytopathol. Soc. Jpn. 63:450-54
75. Makarova KS, Aravind L, Koonin EV. 2000. A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Trends Biochem. Sci. 25:50-52
76. Marais A, Svanella-Dumas L, Foissac X, Gentit P, Candresse T. 2006. Asian prunus viruses: new related members of the family Flexiviridae in Prunus germplasm of Asian origin. Virus Res. 120:176-83
77. Martelli GP, ed. 1993. Graft-Transmissible Diseases of Grapevines. Handbook for Detection and Diagnosis. Rome: FAO Publ. Div. 263 pp.
78. Martelli GP, Russo M. 1984. The use of thin sectioning for visualization and identification of plant viruses. Meth. Virol. 8:143-224
79. Martelli GP, Agranovsky AA, Bar-Joseph M, Boscia D, Candresse T, et al. 2002. The family Closteroviridae revised. Arch. Virol. 147:2039-44
80. Martelli GP, Sabanadzovic S, Abou-Ghanem Sabanadzovic N, Edwards MC, Dreher T. 2002. The family Tymoviridae. Arch. Virol. 147:1837-46
81. GP M, Boudon-Padieu E. 2006. Directory of major infectious diseases of the grapevine. Options Mediterr. B 55:11-201
82. Maury Y, Duby C, Khetarpal RH. 1998. Seed certification for viruses. See Ref. 48, pp. 237-48
83. Melcher U. 2000. The '30K' superfamily of viral movement proteins. J. Gen. Virol. 81:257-66
84. Meng B, Zhu HY, Gonsalves D. 1999. Rupestris stem pitting-associated virus 1 consists of a family of sequence variants. Arch. Virol. 144:2071-85
85. Meng B, Li C, Wang W, Goszczynski D, Gonsalves D. 2005. Complete genome sequence of two new variants of Grapevine rupestris stem pitting-associated virus and comparative analysis. J. Gen. Virol. 86:1555-60
86. Milne RG. 1984. Electron microscopy for the identification of plant viruses in in vitro preparations. Meth. Virol. 7:87-120
87. Milne RG, ed. 1988. The Plant Viruses. Vol. 4: The Filamentous Plant Viruses. New York: Plenum. 423 pp.
88. Mink GI. 1993. Pollen- and seed-transmitted viruses and viroids. Annu. Rev. Phytopathol. 31:375-402
89. Monette PL, ed. 1997. Filamentous Viruses of Woody Plants. Trivandrum: Res. Signpost
90. Morales FJ, Lozano I, Velasco AC, Arroyave GA. 2002. Detection of a fovea-like virus in African oil palm affected by a lethal "ringspot" disease in South America. J. Phytopathol. 150:611-15
91. Morozov SY, Dolja VV, Atabekov JG. 1989. Probable reassortment of genomic elements among elongated RNA-containing plant viruses. J. Mol. Evol. 29:52-62
92. Morozov SY, Miroshnichenko NA, Solovyev AG, Fedorkin ON, Zelenina DA, et al. 1991. Expression strategy of the potato virus X triple gene block. J. Gen. Virol. 72:2039-42
93. Morozov SY, Solovyev AG. 2003. Triple gene block: modular design of a multifunctional machine for plant virus movement. J. Gen. Virol. 84:1351-66
94. Mushegian AR, Koonin EV. 1993. Cell-to-cell movement of plant viruses. Arch. Virol. 133:239-57
95. Nagasaki K, Shirai Y, Takao Y, Mizumoto H, Nishida K, et al. 2005. Comparison of genome sequences of single-stranded RNA viruses infecting the bivalve-killing dinoflagellate Heterocapsa circularisquama. Appl. Environ. Microbiol. 71:8888-94
96. Nemchinov LG, Shamloul AM, Zemtchik EZ, Verderevskaya TD, Hadidi A. 2000. Apricot latent virus: a new species in the genus Foveavirus. Arch. Virol. 145:1801-13
97. Nuss DL. 2005. Hypovirulence: mycoviruses at the fungal-plant interface. Nat. Rev. Microbiol. 3:632-42
98. Ohki ST. 1997. Cytopathology of filamentous viruses infecting fruit trees and woody ornamentals. See Ref. 87a, pp. 171-77
99. Oldfield GN, Proeseler G. 1996. Eriophyoid mites as vectors of plant viruses. In Eriopyoid Mites, Their Biology, Natural Enemies and Control, ed. EE Lindquist, MW Sabelis, J Bruin, pp. 259-75. Amsterdam: Elsevier
100. Parker L, Kendall A, Stubbs G. 2002. Surface feature of Potato virus X from fiber diffraction. Virology 300:291-95
101. Peremyslov W, Andreev IA, Prokhnevsky AI, Duncan GH, Taliansky ME, et al. 2004. Complex molecular architecture of beet yellows virus particles. Proc. Natl. Acad. Sci. USA 101:5030-35
102. Purcifull DE, Edwardson JR. 1981. Potexviruses. See Ref. 64a, pp. 628-93
103. Roistacher CN. 1991. Graft-Transmissible Diseases of Citrus. Handbook for Detection and Diagnosis. Rome: FAO Publ. Div. 286 pp.
104. Rosciglione B, Castellano MA, Martelli GP, Savino V, Cannizzaro G. 1983. Mealybug transmission of grapevine virus A. Vitis 22:331-47
105. Rozanov MN, Morozov SY, Skryabin KG. 1990. Unexpected close relationship between the large nonvirion proteins of filamentous potexviruses and spherical tymoviruses. Virus Genes 3:373-79
106. Rozanov MN, Koonin EV, Gorbalenya AE. 1992. Conservation of the putative methyltransferase domain: a hallmark of the 'Sindbis-like' supergroup of positive-strand RNA viruses. J. Gen. Virol. 73:2129-34
107. Saldarelli P, Minafra A, Castellano MA, Martelli GP. 2000. Immunodetection and subcellular localization of the proteins encoded by ORF 3 of grapevine viruses A and B. Arch. Virol. 145:1535-42
108. Satyanarayana T, Gowda S, Ayllon MA, Dawson WO. 2004. Closterovirus bipolar virion: evidence for initiation of assembly by minor coat protein and its restriction to the genomic RNA 5′ region. Proc. Natl. Acad. Sci. USA 101:799-804
109. Shi BJ, Habili N, Gafny R, Symons RH. 2004. Extensive variations of sequence within isolates of Grapevine virus B. Virus Genes 29:279-85
110. Stubbs G, Parker L, Junn J, Kendall A. 2005. Flexible filamentous virus structures from fiber diffraction. Fiber Diffract. Rev. 13:38-42
111. Susaimuthu J, Tzanetakis IE, Gergerich RC, Martin RR. 2006. Blackberry virus Y: a potyvirus component of blackberry yellows disease. Phytopathology 96:S112
112. Takao Y, Mise K, Nagasaki K, Okuno T, Honda D. 2006. Complete nucleotide sequence and genome organization of a single-stranded RNA virus infecting the marine fungoid protist Schizochytrium sp. J. Gen. Virol. 87:723-33
113. Terai Y, Yanase H. 1992. Induction of berry necrosis in Kyoho back-inoculated with the virus isolate from grapevine mosaic diseases clones and renaming to grapevine berry inner necrosis. Ann. Phytopathol. Soc. Jpn. 58:617
114. Torrance L, Andreev IA, Gabrenaite-Verhovskaya R, Cowan G, Makinen K, et al. 2005. An unusual structure at one end of potato potyvirus particles. J. Mol. Biol. 357:1-8
115. Teycheney PY, Marais A, Svanella-Dumas L, Dulucq MJ, Candresse T. 2005. Molecular characterization of banana virus X (BVX), a novel member of the Flexiviridae family. Arch. Virol. 150:1715-27
116. Tollin T, Wilson HR. 1988. Particle structure. See Ref. 86, 4:51-83
117. Urcuqui-Inchima S, Haenni AL, Bernardi F. 2001. Potyvirus proteins: a wealth of functions. Virus Res. 74:157-75
118. Van Djik P, Veerbek M, Bos L. 1991. Mite-borne viruses isolates from cultivated Allium species and their classification into two new rymoviruses in the family Potyviridae. Neth. J. Plant Pathol. 97:381-99
119. Van Djik P, Van der Vlugt RAA. 1994. New mite-borne viruses isolated from rakkyo, shallot and wild leek species. Eur. J. Plant Pathol. 100:269-77
120. Verchot J, Angell SM, Baulcombe DC. 1998. In vivo translation of the triple gene block of potato virus X requires two subgenomic mRNAs. J. Virol. 72:8316-20
121. Verchot-Lubicz J. 2005. A new cell-to-cell transport model for potexviruses. Mol. Plant Microbe Interact. 18:283-90
122. Vishnichenko VK, Stelmashchuk VY, Zavriev SK. 2002. The 42K protein of the Shallot virus X participates in formation of virus particles. Mol. Biol. 36:1080-84
123. Vives MC, Galipienso L, Navarro L, Moreno P, Guerri J. 2001. The nucleotide sequence and menome organisation of citrus leaf blotch virus: candidate type species for a new virus genus. Virology 287:225-33
124. Voinnet O, Ledere C, Baulcombe DC. 2000. A viral movement protein prevents spread of the gene silencing signal in Nicotiana benthamiana. Cell 103:157-67
125. Wetter C, Milne RG. 1981. Carlaviruses. See Ref. 64a, pp. 696-730
126. Xie J, Wei D, Jiang D, Fu Y, Li G, et al. 2006. Characterization of debilitation-associated mycovirus infecting the plant-pathogenic fungus Sclerotinia sclerotiorum. J. Gen. Virol. 87:241-49
127. Yaegashi H, Takahashi T, Isogai M, Kobori T, Ohki S, Yoshikawa N. 2007. Apple chlorotic leaf spot virus 50 kDa movement protein acts as a suppressor of systemic silencing without interfering with local silencing in Nicotiana benthamiana. J. Gen. Virol. 88:316-24
128. Zhang YP, Uyemotyo JK, Kirkpatrick BC. 1998b. Analysis of double stranded RNAs from cherry trees with stem pitting in California. Plant Dis. 82:871-74
129. Zhou SZH, Dell'Orco M, Saldarelli P, Turturo C, Minafra A, et al. 2006. Identification of an RNA silencing suppressor in the genome of Grapevine virus A. J. Gen. Virol. 87:2387-95