Steroid-resistant nephrotic syndrome: Long-term evolution after sequential therapy

Pediatric Nephrology

Volumn 22, Issue 11, 2007, Pages 1875-1880

  Peña, Antonia ^a   Bravo, Juan ^a   Melgosa, Marta ^a   Fernandez, Carlota ^a   Meseguer, Carmen ^a   Espinosa, Laura ^a   Alonso, Angel ^a   Picazo, M Luz ^b   Navarro, Mercedes ^a  

^a HOSPITAL INFANTIL LA PAZ   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Children; Cyclosporine; Methylprednisolone; Mycophenolate mofetil; Pulses; Steroid resistant nephritic syndrome; Tacrolimus

Indexed keywords

ANTIBIOTIC AGENT; CALCIUM; CHLORAMBUCIL; COLECALCIFEROL; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYCLOSPORIN A; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PODOCIN; PREDNISONE; STEROID;

ARTICLE; BODY MASS; CATARACT; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; DRUG DOSE REDUCTION; DRUG RESPONSE; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; FOCAL GLOMERULONEPHRITIS; FOLLOW UP; GENE MUTATION; HETEROZYGOTE; HIRSUTISM; HISTOPATHOLOGY; HUMAN; INFANT; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LOW DRUG DOSE; MALE; MINIMAL CHANGE GLOMERULONEPHRITIS; NEPHROTIC SYNDROME; OSTEOPENIA; PERITONITIS; PRIORITY JOURNAL; PROGNOSIS; PROLIFERATIVE GLOMERULONEPHRITIS; REMISSION; SEPSIS; SIDE EFFECT; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANTI-INFLAMMATORY AGENTS; CHILD; CHILD, PRESCHOOL; CYCLOPHOSPHAMIDE; DISEASE PROGRESSION; DRUG RESISTANCE; FOLLOW-UP STUDIES; GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; INJECTIONS, INTRAVENOUS; MALE; METHYLPREDNISOLONE; NEPHROSIS, LIPOID; NEPHROTIC SYNDROME; REMISSION INDUCTION; RETROSPECTIVE STUDIES; SPAIN;

EID: 34848815017     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-007-0567-2     Document Type: Article

References (45)

1. Koskimies O, Vilska J, Rapola J, Hallman N (1982) Long-term outcome of primary nephrotic syndrome. Arch Dis Child 57:544-548
2. Cattran DC, Rao P (1998) Long-term outcome in children and adults with classic focal segmental glomerulosclerosis. Am J Kidney Dis 32:72-79
3. Tarshish P, Tobin JN, Bernstein J, Edelmann CM Jr (1996) Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis. A report of the International Study of Kidney Disease in Children. Pediatr Nephrol 10:590-593
4. Tejani A (1985) Morphological transition in minimal change nephrotic syndrome. Nephron 39:157-159
5. Tejani A, Nicastri AD, Sen D, Chen CK, Phadke K, Adamson O, Butt KM (1983) Long-term evaluation of children with nephrotic syndrome and focal segmental glomerular sclerosis. Nephron 35:225-231
6. Mendoza SA, Reznik VM, Griswold WR, Krensky AM, Yorgin PD, Tune BM (1990) Treatment of steroid-resistant focal segmental glomerulosclerosis with pulse methylprednisolone and alkylating agents. Pediatr Nephrol 4:303-307
7. Hodson EM, Habashy D, Craig JC (2006) Interventions for idiopathic steroid-resistant nephrotic syndrome in children. Cochrane Database Syst Rev CD003594
8. International Study of Kidney Disease in Children (1974) Prospective, controlled trial of cyclophosphamide therapy in children with nephrotic syndrome. Report of the International study of Kidney Disease in Children. Lancet 2:423-427
9. Rose GM, Cole BR, Robson AM (1981) The treatment of severe glomerulopathies in children using high dose intravenous methylprednisolone pulses. Am J Kidney Dis 1:148-156
10. Tarshish P, Tobin JN, Bernstein J, Edelmann CM Jr (1997) Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. J Am Soc Nephrol 8:769-776
11. Alshaya HO, Al-Maghrabi JA, Kari JA (2003) Intravenous pulse cyclophosphamide - is it effective in children with steroid-resistant nephrotic syndrome? Pediatr Nephrol 18:1143-1146
12. Hari P, Bagga A, Jindal N, Srivastava RN (2001) Treatment of focal glomerulosclerosis with pulse steroids and oral cyclophosphamide. Pediatr Nephrol 16:901-905
13. Yorgin PD, Krasher J, Al Uzri AY (2001) Pulse methylprednisolone treatment of idiopathic steroid-resistant nephrotic syndrome. Pediatr Nephrol 16:245-250
14. Tune BM, Kirpekar R, Sibley RK, Reznik VM, Griswold WR, Mendoza SA (1995) Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: A long-term follow-up. Clin Nephrol 43:84-88
15. Mori K, Honda M, Ikeda M (2004) Efficacy of methylprednisolone pulse therapy in steroid-resistant nephrotic syndrome. Pediatr Nephrol 19:1232-1236
16. Kirpekar R, Yorgin PD, Tune BM, Kim MK, Sibley RK (2002) Clinicopathologic correlates predict the outcome in children with steroid-resistant idiopathic nephrotic syndrome treated with pulse methylprednisolone therapy. Am J Kidney Dis 39:1143-1152
17. Bajpai A, Bagga A, Hari P, Dinda A, Srivastava RN (2003) Intravenous cyclophosphamide in steroid-resistant nephrotic syndrome. Pediatr Nephrol 18:351-356
18. Schonwald S (1999) Methylprednisolone anaphylaxis. Am J Emerg Med 17:583-585
19. Saito R, Moroi S, Okuno H, Ogawa O (2004) Anaphylaxis following administration of intravenous methylprednisolone sodium succinate in a renal transplant recipient. Int J Urol 11:171-174
20. Butani L (2002) Corticosteroid-induced hypersensibility reactions. Ann Allergy Asthma Immunol 89:439-445
21. Latta K, von Schnakenburg C, Ehrich JH (2001) A meta-analysis of cytotoxic treatment for frequently relapsing nephrotic syndrome in children. Pediatr Nephrol 16:271-282
22. Ponticelli C, Rizzoni G, Edefonti A, Altieri P, Rivolta E, Rinaldi S, Ghio L, Lusvarghi E, Gusmano R, Locatelli F (1993) A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome. Kidney Int 43:1377-1384
23. Niaudet P (1994) Treatment of childhood steroid-resistant idiopathic nephrosis with a combination of cyclosporine and prednisone. French Society of Pediatric Nephrology. J Pediatr 125:981-986
24. Hymes LC (1995) Steroid-resistant, cyclosporine-responsive, relapsing nephrotic syndrome. Pediatr Nephrol 9:137-139
25. Sancewicz-Pach K, Slowiaczek E, Kwinta-Rybicka J, Wilkosz K, Drozdz D, Nowak J (1996) Long-term cyclosporine A (Sandimmun) therapy for steroid resistant nephrotic syndrome in children. Przegl Lek 53:365-368
26. Gregory MJ, Smoyer WE, Sedman A, Kershaw DB, Valentini RP, Johnson K, Bunchman TE (1996) Long-term cyclosporine therapy for pediatric nephrotic syndrome: A clinical and histologic analysis. J Am Soc Nephrol 7:543-549
27. Garcia C, Michelon T, Barros V, Mota D, Uhlmann A, Randon R, Ramalho H, Abbud FM (1998) Cyclosporine in the treatment of steroid-dependent and steroid-resistant idiopathic nephrotic syndrome in children. Transplant Proc 30:4156-4157
28. Habashy D, Hodson E, Craig J (2004) Interventions for idiopathic steroid-resistant nephrotic syndrome in children. Cochrane Database Syst Rev CD003594
29. El-Husseini A, El-Basuony F, Mahmoud I, Sheashaa H, Sabry A, Hassan R, Taha N, Hassan N, Sayed-Ahmad N, Sobh M (2005) Long-term effects of cyclosporine in children with idiopathic nephrotic syndrome: A single-centre experience. Nephrol Dial Transplant 20:2433-2438
30. Frassinetti Castelo Branco Camurca Fernandes P, Bezerra Da Silva G Jr, De Sousa Barros FA, Costa Oliveira CM, Kubrusly M, Evangelista JB Jr (2005) Treatment of steroid-resistant nephrotic syndrome with cyclosporine: Study of 17 cases and a literature review. J Nephrol 18:711-720
31. Mahmoud I, Basuni F, Sabry A, El-Husseini A, Hassan N, Ahmad NS, Elbaz M, Moustafa F, Sobh M (2005) Single-centre experience with cyclosporin in 106 children with idiopathic focal segmental glomerulosclerosis. Nephrol Dial Transplant 20:735-742
32. McCauley J, Shapiro R, Ellis D, Igdal H, Tzakis A, Starzl TE (1993) Pilot trial of FK 506 in the management of steroid-resistant nephrotic syndrome. Nephrol Dial Transplant 8:1286-1290
33. McCauley J, Shapiro R, Scantlebury V, Gilboa N, Jordan M, Jensen C, Naik A, Tzakis A, Ellis D, Starzl TE (1991) FK 506 in the management of transplant-related nephrotic syndrome and steroid-resistant nephrotic syndrome. Transplant Proc 23:3354-3356
34. Segarra A, Vila J, Pou L, Majo J, Arbos A, Quiles T, Piera LL (2002) Combined therapy of tacrolimus and corticosteroids in cyclosporin-resistant or -dependent idiopathic focal glomerulosclerosis: a preliminary uncontrolled study with prospective follow-up. Nephrol Dial Transplant 17:655-662
35. Loeffler K, Gowrishankar M, Yiu V (2004) Tacrolimus therapy in pediatric patients with treatment-resistant nephrotic syndrome. Pediatr Nephrol 19:281-287
36. Tsugawa K, Tanaka H, Nakahata T, Ito E (2004) Effective therapy of a child case of refractory nephrotic syndrome with tacrolimus. Tohoku J Exp Med 204:237-241
37. Cattran DC, Wang MM, Appel G, Matalon A, Briggs W (2004) Mycophenolate mofetil in the treatment of focal segmental glomerulosclerosis. Clin Nephrol 62:405-411
38. Bagga A, Hari P, Moudgil A, Jordan SC (2003) Mycophenolate mofetil and prednisolone therapy in children with steroid-dependent nephrotic syndrome. Am J Kidney Dis 42:1114-1120
39. Barletta GM, Smoyer WE, Bunchman TE, Flynn JT, Kershaw DB (2003) Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome. Pediatr Nephrol 18:833-837
40. Day CJ, Cockwell P, Lipkin GW, Savage CO, Howie AJ, Adu D (2002) Mycophenolate mofetil in the treatment of resistant idiopathic nephrotic syndrome. Nephrol Dial Transplant 17:2011-2013
41. Chandra M, Susin M, Abitbol C (2000) Remission of relapsing childhood nephrotic syndrome with mycophenolate mofetil. Pediatr Nephrol 14:224-226
42. Mendizabal S, Zamora I, Berbel O, Sanahuja MJ, Fuentes J, Simon J (2005) Mycophenolate mofetil in steroid/cyclosporine-dependent/resistant nephrotic syndrome. Pediatr Nephrol 20:914-919
43. Fuchshuber A, Gribouval O, Ronner V, Kroiss S, Karle S, Brandis M, Hildebrandt F (2001) Clinical and genetic evaluation of familial steroid-responsive nephrotic syndrome in childhood. J Am Soc Nephrol 12:374-378
44. Karle SM, Uetz B, Ronner V, Glaeser L, Hildebrandt F, Fuchshuber A (2002) Novel mutations in NPHS2 detected in both familial and sporadic steroid-resistant nephrotic syndrome. J Am Soc Nephrol 13:388-393
45. Ruf RG, Lichtenberger A, Karle SM, Haas JP, Anacleto FE, Schultheiss M, Zalewski I, Imm A, Ruf EM, Mucha B, Bagga A, Neuhaus T, Fuchshuber A, Bakkaloglu A, Hildebrandt F (2004) Patients with mutations in NPHS2 (podocin) do not respond to standard steroid treatment of nephrotic syndrome. J Am Soc Nephrol 15:722-732