Long-Term Cyclosporine Therapy for Pediatric Nephrotic Syndrome: A Clinical and Histologie Analysis

Journal of the American Society of Nephrology

Volumn 7, Issue 4, 1996, Pages 543-549

  Gregory, Melissa J ^a,b   Smoyer, William E ^a   Sedman, Aileen ^a   Kershaw, David B ^a   Valentini, Rudolph P ^a   Johnson, Kent ^a   Bunchman, Timothy E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Cyclosporine; IgM nephropathy; Pediatrics; Steroid dependent nephrotic syndrome; Steroid resistant nephrotic syndrome

Indexed keywords

CYCLOSPORIN; PREDNISONE;

ADOLESCENT; ARTICLE; BIOPSY; BLOOD; CHILD; CLINICAL TRIAL; DRUG COMBINATION; FEMALE; FOCAL GLOMERULOSCLEROSIS; HUMAN; LIPOID NEPHROSIS; MALE; NEPHROTIC SYNDROME; PATHOLOGY; PRESCHOOL CHILD;

ADOLESCENT; BIOPSY; CHILD; CHILD, PRESCHOOL; CYCLOSPORINE; DRUG THERAPY, COMBINATION; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; MALE; NEPHROSIS, LIPOID; NEPHROTIC SYNDROME; PREDNISONE;

EID: 0030124088     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/asn.v74543     Document Type: Article

References (46)

1. Calne RY, Thiru S, McMaster P, et al.: Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet 1978;2:1323-1327.
2. Collaborative Study Group of Sandimmun in Nephrotic Syndrome: Safety and tolerability of cyclosporin A (Sandimmun) in idiopathic nephrotic syndrome. Clin Nephrol 1991;35:S48-S60.
3. Klintmalm G, Sundelin B, Bohman SO, Wilczek H: Interstitial fibrosis in renal allografts after 12 to 46 months of cyclosporin treatments: Beneficial effect of low doses in early post-transplant period. Lancet 1984;2: 950-954.
4. Mihatsch MJ, Thiel G, Basler V, et al.: Morphological patterns in cyclosporine-treated renal transplant recipients. Tranplant Proc 1985;XVII:101-116.
5. Mihatsch MJ, Helmchen V: Kidney biopsy findings in cyclosporine-treated patients with insulin-dependent diabetes mellitus. Klin Wochenschr 1991;69:354-359.
6. Feutren G, Mihatsch M: Risk factors for cyclosporine-induced nephrotoxicity in patients with autoimmune diseases. N Engl J Med 1992;326:1654-1660.
7. Sieberth HG, Clasen W, Fuhs M, Ittel T, Kindler J, Mihatsch MJ: Serial kidney biopsies in patients with nephrotic syndrome treated with cyclosporin. J Autoimmunity 1992;5[Suppl A]:355-361.
8. Brodehl J, Hoyer PF, Oemar BS, Helmchen U, Wonigeit K: Cyclosporine treatment of nephrotic syndrome in children. Transplant Proc 1988;XX:269-274.
9. Brodehl J, Hoyer PF: Ciclosporin in idiopathic nephrotic syndrome of children. Am J Nephrol 1989;9:61-64.
10. Capodicasa G, De Santo N, Nuzzi F, Giordano C: Cyclosporin A in nephrotic syndrome of childhood - A 14 month experience. Int J Pediatr Nephrol 1986;7:69-72.
11. Hoyer PF, Krull F, Brodehl J: Cyclosporin in frequently relapsing minimal change nephrotic syndrome [Letter]. Lancet 1986;2:335.
12. Brandis M, Burghard R, Letitis J, Zimmerhackl B, Hildebrandt F, Helmchen U: Cyclosporin A for treatment in nephrotic syndromes [Abstract]. Pediatr Nephrol 1987;1:C42A.
13. Tejani A, Butt K, Trachtman H, Suthanthiran M, Rosenthal CJ, Khawar MR: Cyclosporine-induced remission of relapsing nephrotic syndrome in children. J Pediatr 1987;111:1056-1062.
14. Garin EH, Orak JK, Hiott KL, Sutherland SE: Cyclosporine therapy for steroid-resistant nephrotic syndrome. Am J Dis Child 1988;142:985-988.
15. Niaudet P, Habib R, Tete MJ, Hinglais N, Broyer M: Cyclosporin in the treatment of idiopathic nephrotic syndrome in children. Pediatr Nephrol 1987;1:566-573.
16. Ponticelli C, Rizzoni G, Edefonti A, et al.: A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome. Kidney Int 1993;43:1377-1384.
17. Meyrier A, Condamin MC, Broneer D: Treatment of adult idiopathic nephrotic syndrome with Cyclosporin A: Minimal-change disease and focal-segmental glomerulosclerosis. Clin Nephrol 1991;35(Suppl 1):S37-S42.
18. Hymes LC: Steroid-resistant cyclosporine-responsive, relapsing nephrotic syndrome. Pediatr Nephrol 1995;9: 137-139.
19. Lawler W, Williams G, Tarpey P, Mallick NP: IgM associated primary diffuse mesangial proliferative glomerulonephritis. J Clin Pathol 1980;33:1029-1031.
20. Tejani A, Nicastri AD: Mesangial IgM nephropathy. Nephron 1983;35:1-5.
21. Allen WR, Travis LB, Cavallo T, Brouhard BH, Cunningham RJ III: Immune deposits and mesangial hypercellularity in minimal change nephrotic syndrome: Clinical relevance. J Pediatr 1982;100:188-191.
22. Tejani A, Butt K, Trachtman H, Suthanthiran M, Rosenthal CJ, Khawar MR: Cyclosporine A induced remission of relapsing nephrotic syndrome in children. Kidney Int 1988;33:729-734.
23. Niaudet P, Broyer M, Habib R: Treatment of idiopathic nephrotic syndrome with Cyclosporin A in children. Clin Nephrol 1991;35(Suppl 1):S31-S36.
24. Kitano Y, Yoshikawa N, Tanaka R, Nakamura H, Ninomiya M, Ito H: Ciclosporin treatment in children with steroid-dependent nephrotic syndrome. Pediatr Nephrol 1990;4:474-477.
25. Tanaka R, Yoshikawa N, Kitano Y, Ito H, Nakamura H: Long-term ciclosporin treatment in children with steroid-dependent nephrotic syndrome. Pediatr Nephrol 1993;7:249-252.
26. Neuhaus TJ, Burger HR, Klingler M, Fanconi A, Leumann EP: Long-term low-dose Cyclosporin A in steroid dependent nephrotic syndrome of childhood. Eur J Pediatr 1992;151:775-778.
27. Cohen AH, Border WA, Glassock RJ: Nephrotic syndrome with glomerular mesangial IgM deposits. Lab Invest 1977;36:334-335.
28. Andal A, Saxena S, Chellani, Sharma S: Pure mesangial proliferative glomerulonephritis: A clinicomorphologic analysis and its possible role in morphologie transition of minimal change lesion. Nephron 1989;51:314-319.
29. Ji-Yun Y, Melvin T, Sibley R, Michael AF: No evidence for a specific role of IgM in mesangial proliferation of idiopathic nephrotic syndrome. Kidney Int 1984;25:100-106.
30. Mampaso F, Gonzalo A, Teruel J, Losada M, Gallego N, Ortuno J, Bellas C: Mesangial deposits of IgM in patients with the nephrotic syndrome. Clin Nephrol 1981;16: 230-234.
31. Vilches AR, Turner DR, Cameron JS, Ogg CS, Changler C, Williams DG: Significance of mesangial IgM deposition in "minimal change" nephrotic syndrome. Lab Invest 1982;1:10-15.
32. Habib R, Girardin E, Gagnadoux M, Hinglai N, Levy M, Broyer M: Immunopathological findings in idiopathic nephrosis: clinical significance of glomerular "immune deposits." Pediatr Nephrol 1988;2:402-408.
33. Gonzalo A, Mampaso F, Gallego N, Quereda C, Fierro C, Ortuno J: Clinical significance of IgM mesangial deposits in the nephrotic syndrome. Nephron 1985;41:246-249.
34. Southwest Pediatric Nephrology Study Group: Childhood nephrotic syndrome associated with diffuse mesangial hypercellularity. Kidney Int 1983;23:87-94.
35. International Study of Kidney Disease in Children: Primary nephrotic syndrome in children: Clinical significance of histopathologic variants of minimal change and of diffuse mesangial hypercellularity. Kidney Int 1981; 20:765-771.
36. Molocoton TL, Kamil ES, Cohen AH, Fine RN: Long-term cyclosporine A treatment of steroid-resistant and steroid-dependent nephrotic syndrome. Am J Kidney Dis 1991;18:583-588.
37. Brandis M, Burghard R, Letitis J, Zimmerhackl B, Hildebrandt F, Helmchen U: Cyclosporine A for the treatment of nephrotic syndrome. Transplant Proc 1988; XX:275-279.
38. Meyrier A, Simon P, Perret G, Condamin-Meyrier MC: Remission of idiopathic nephrotic syndrome after treatment with cyclosporin A. Br Med J 1986;292:789-792.
39. Niaudet P, the French Society of Pediatric Nephrology: Treatment of childhood steroid-resistant idiopathic nephrosis with a combination of cyclosporine and prednisone. J Pediatr 1994;125:981-986.
40. Tejani A, Lieberman K: A randomized placebo controlled double blind trial of cyclosporine in steroid resistant idiopathic focal segmental glomerulosclerosis in children: A report of the New York, New Jersey Pediatric Study Group [Abstract]. J Am Soc Nephrol 1993;4:289A.
41. Inguilli E, Tejani A: Racial differences in the incidence and renal outcome of idiopathic focal segmental glomerulosclerosis in children. Pediatr Nephrol 1991;5:393-397.
42. Habib R, Niaudet P: Comparison between pre- and post-treatment renal biopsies in children receiving ciclosporine for idiopathic nephrosis. Clin Nephrol 1994;42:141-146.
43. Wiener RH, Ludwig J, Lindor KD, et al.: A controlled trial of cyclosporine in the treatment of primary biliary cirrhosis. N Engl J Med 1990;322:1419-1424.
44. Palestine AG, Austin HA III, Balow JE, et al.: Renal histopathologic alterations in patients treated with cyclosporine for uveitis. N Engl J Med 1986;314:1293-1298.
45. Ellis CN, Fradin MS, Messana JM, et al.: Cyclosporine for plaque-type psoriasis. N Engl J Med 1991;324:277-284.
46. Niaudet P, Habib R, Gagnadoux MF, Tete MJ, Broyer M: Treatment of severe childhood nephrosis. Adv Nephrol 1988;17:151-172.