Impact of the ratio of intravenous omega-3 vs. omega-6 polyunsaturated fatty acids in postoperative and in septic patients-A post hoc database analysis

e-SPEN

Volumn 2, Issue 5, 2007, Pages

  Heller, Axel R ^a   Stengel, Stefanie ^a   Stehr, Sebastian N ^a   Gama de Abreu, Marcelo ^a   Koch, Rainer ^b   Koch, Thea ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Acute phase response; Fish oil; Immuno nutrition; Inflammation; Omega 3 fatty acids; Parenteral nutrition; Soybean oil

Indexed keywords

ANTIBIOTIC AGENT; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OMEGAVEN-FRESENIUS; POLYUNSATURATED FATTY ACID; SOYBEAN OIL; UNCLASSIFIED DRUG;

ABDOMINAL SURGERY; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL TRIAL; DATA BASE; EVALUATION; FATTY ACID ANALYSIS; FEMALE; GERMANY; HUMAN; INTENSIVE CARE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL ANALYSIS; MORBIDITY; MORTALITY; MULTICENTER STUDY; OMEGA 3 OMEGA 6 FATTY ACID RATIO; OUTCOME ASSESSMENT; PERITONITIS; POSTOPERATIVE CARE; RISK REDUCTION; SEPSIS; TOTAL PARENTERAL NUTRITION; TREATMENT OUTCOME;

EID: 34748894520     PISSN: 17514991     EISSN: 17514991     Source Type: Journal    
DOI: 10.1016/j.eclnm.2007.07.002     Document Type: Article

References (23)

1. Tsekos E., Reuter C., Stehle P., and Boeden G. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery. Clin Nutr 23 3 (2004) 325-330
2. Heller A.R., Rössel T., Gottschlich B., Tiebel O., Menschikowski M., Litz R.J., et al. Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients. Int J Cancer 111 4 (2004) 611-616
3. Gadek J.E., DeMichele S.J., Karlstad M.D., Pacht E.R., Donahoe M., Albertson T.E., et al. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. Crit Care Med 27 8 (1999) 1409-1420
4. Pontes-Arruda A., Aragao A.M., and Albuquerque J.D. Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. Crit Care Med 34 9 (2006) 2325-2333
5. Heller A.R., Fischer S., Rössel T., Geiger S., Siegert G., Ragaller M., et al. Impact of n-3 fatty acid supplemented parenteral nutrition on haemostasis patterns after major abdominal surgery. Br J Nutr 87 Suppl 1 (2002) S95-S101
6. Calder P.C., Yaqoob P., Thies F., Wallace F.A., and Miles E.A. Fatty acids and lymphocyte functions. Br J Nutr 87 Suppl 1 (2002) S31-S48
7. Waitzberg D.L., Lotierzo P.H., Logullo A.F., Torrinhas R.S., Pereira C.C., and Meier R. Parenteral lipid emulsions and phagocytic systems. Br J Nutr 87 Suppl 1 (2002) S49-S57
8. Grimm H., Mayer K., Mayser P., and Eigenbrodt E. Regulatory potential of n-3 fatty acids in immunological and inflammatory processes. Br J Nutr 87 Suppl 1 (2002) S59-S67
9. Yaqoob P. Lipids and the immune response. Curr Opin Clin Nutr Metab Care 1 2 (1998) 153-161
10. Koch T., and Heller A. Effects of intravenous fish oil on pulmonary integrity and function. Clin Nutr 21 Suppl (2002) 41-45
11. Heller A.R., Rössler S., Litz R.J., Stehr S.N., Heller S.C., Koch R., et al. Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med 34 4 (2006) 972-979
12. Peck M.D., Ogle C.K., and Alexander J.W. Composition of fat in enteral diets can influence outcome in experimental peritonitis. Ann Surg 214 1 (1991) 74-82
13. Grimm H., Tibell A., Norrlind B., Blecher C., Wilker S., and Schwemmle K. Immunoregulation by parenteral lipids: impact of the n-3 to n-6 fatty acid ratio. J Parenter Enteral Nutr 18 5 (1994) 417-421
14. Morlion B.J., Torwesten E., Wrenger K., Puchstein C., and Fürst P. What is the optimum n-3 to n-6 fatty acid ratio of parenteral lipid emulsions in postoperative trauma?. Clin Nutr 16 Suppl 2 (1997) 49
15. Harris W.S., Assaad B., and Poston W.C. Tissue omega-6/omega-3 fatty acid ratio and risk for coronary artery disease. Am J Cardiol 98 4A (2006) 19i-26i
16. Garcia-de-Lorenzo A., Denia R., Atlan P., Martinez-Ratero S., Le B.A., Evard D., et al. Parenteral nutrition providing a restricted amount of linoleic acid in severely burned patients: a randomised double-blind study of an olive oil-based lipid emulsion v. medium/long-chain triacylglycerols. Br J Nutr 94 2 (2005) 221-230
17. Mayer K., Grimm H., Grimminger F., and Seeger W. Parenteral nutrition with n-3 lipids in sepsis. Br J Nutr 87 Suppl 1 (2002) S69-S75
18. Singer P., Theilla M., Fisher H., Gibstein L., Grozovski E., and Cohen J. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med 34 4 (2006) 1033-1038
19. Heller A.R., Theilen H.J., and Koch T. Fish or chips?. News Physiol Sci 18 (2003) 50-54
20. Pscheidl E., Schywalsky M., Tschaikowsky K., and Boke-Prols T. Fish oil-supplemented parenteral diets normalize splanchnic blood flow and improve killing of translocated bacteria in a low-dose endotoxin rat model. Crit Care Med 28 5 (2000) 1489-1496
21. Pscheidl E.M., Wan J.M., Blackburn G.L., Bistrian B.R., and Istfan N.W. Influence of omega-3 fatty acids on splanchnic blood flow and lactate metabolism in an endotoxemic rat model. Metabolism 41 7 (1992) 698-705
22. Kelbel I., Koch T., Prechtl A., Heller A., Schlotzer E., Schiefer G., et al. Effects of parenteral application of fish oil versus soy oil emulsions on bacterial clearance functions. Infusionsther Transfusionsmed 26 (1999) 226-232
23. Weimann A. Omega-3 fatty acids-supplemented parenteral nutrition in the critically ill: another step forward on the "great journey"?. Crit Care Med 34 4 (2006) 1253-1255