Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines

Toxicological Sciences

Volumn 81, Issue 2, 2004, Pages 401-407

  Simanainen, Ulla ^a,b   Adamsson, Annika ^c   Tuomisto, Jouni T ^a   Miettinen, Hanna M ^a   Toppari, Jorma ^c   Tuomisto, Juoko ^a,b   Viluksela, Matti ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Adult exposure; Dioxin; Male reproductive toxicity; Strain differences; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; TESTOSTERONE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS; EXPOSURE; GENE MUTATION; HEREDITY; LETHALITY; MALE; MALE GENITAL SYSTEM; NONHUMAN; ORGAN WEIGHT; PROSTATE VENTRAL LOBE; RAT; RAT STRAIN; SEMINAL VESICLE; SENSITIVITY ANALYSIS; SPERMATOGENESIS; SPERMATOZOON COUNT; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL;

ALLELES; ANIMALS; BODY WEIGHT; ENVIRONMENTAL POLLUTANTS; EPIDIDYMIS; GENITALIA, MALE; MALE; ORGAN SIZE; RATS; RATS, LONG-EVANS; RATS, WISTAR; RECEPTORS, ARYL HYDROCARBON; SEMINAL VESICLES; SERTOLI CELLS; SPERM COUNT; SPERM HEAD; SPERMATOGENESIS; TESTIS; TESTOSTERONE; TETRACHLORODIBENZODIOXIN;

EID: 5744234424     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh212     Document Type: Article

References (20)

1. Bookstaff, R. C., Moore, R. W., and Peterson, R. E. (1990). 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the potency of androgens and estrogens as feed-back inhibitors of luteinizing hormone secretion in male rats. Toxicol. Appl. Pharmacol. 104, 212-224.
2. Chahoud, I., Hartmann, J., Rune, G. M., and Neubert, D. (1992). Reproductive toxicity and toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects of single doses on the testis of male rats. Arch. Toxicol. 66, 567-572.
3. el-Sabeawy, F., Wang, S., Overstreet, J., Miller, M., Lasley, B., and Enan, E. (1998). Treatment of rats during pubertal development with 2,3,7,8-tetrachlorodibenzo-p-dioxin alters both signaling kinase activities and epidermal growth factor receptor binding in the testis and the motility and acrosomal reaction of sperm. Toxicol. Appl. Pharmacol. 150, 427-442.
4. Johnson, L., Dickerson, R., Safe, S. H., Nyberg, C. L., Lewis, R. P., and Welsh, T. H., Jr. (1992). Reduced Leydig cell volume and function in adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis. Toxicology 76, 103-118.
5. Ko, H. P., Okino, S. T., Ma, Q., and Whitlock, J. P., Jr. (1996). Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol. Cell Biol. 16, 430-436.
6. Kronenberg, S., Esser, C., and Carlberg, C. (2000). An aryl hydrocarbon receptor conformation acts as the functional core of nuclear dioxin signaling. Nucleic Acids Res. 28, 2286-2291.
7. Latchoumycandane, C., Chitra, K. C., and Mathur, P. P. (2002). The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antioxidant system in mitochondrial and microsomal fractions of rat testis. Toxicology 171, 127-135.
8. Moore, R. W., Potter, C. L., Theobald, H. M., Robinson, J. A., and Peterson, R. E. (1985). Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 79, 99-111.
9. Peterson, R. E., Theobald, H. M., and Kimmel, G. L. (1993). Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisons. Crit. Rev. Toxicol. 23, 283-335.
10. Pohjanvirta, R. (1990). TCDD resistance is inherited as an autosomal dominant trait in the rat. Toxicol. Lett. 50, 49-56.
11. Pohjanvirta, R., Viluksela, M., Tuomisto, J. T., Unkila, M., Karasinska, J., Franc, M. A., Holowenko, M., Giannone, J. V., Harper, P. A., Tuomisto, J., and Okey, A. B. (1999). Physicochemical differences in the AH receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains. Toxicol. Appl. Pharmacol. 155, 82-95.
12. Pohjanvirta, R., Wong, J. M., Li, W., Harper, P. A., Tuomisto, J., and Okey, A. B. (1998). Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain. Mol. Pharmacol. 54, 86-93.
13. Roman, B. L., and Peterson, R. E. (1998). Developmental male reproductive toxicology of 2,3,7,8-tetrachlorodibezo-p-dioxin (TCDD) and PCBs. In Reproductive and Developmental Toxicology (K. S. Korach, Eds.), pp. 593-624. Marcel-Dekker, New York.
14. Rune, G. M., de Souza, P., Krowke, R., Merker, H. J., and Neubert, D. (1991). Morphological and histochemical pattern of response in rat testes after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Histol. Histopathol. 6, 459-467.
15. Simanainen, U., Haavisto, T., Tuomisto, J. T., Paranko, J., Toppari, J., Tuomisto, J., Peterson, R. E., and Viluksela, M. (2004). Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three differentially TCDD-sensitive rat lines. Toxicol. Sci. 80, 101-108.
16. Simanainen, U., Tuomisto, J. T., Tuomisto, J., and Viluksela, M. (2002). Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains. Toxicol. Appl. Pharmacol. 181, 38-47.
17. Simanainen, U., Tuomisto, J. T., Tuomisto, J., and Viluksela, M. (2003). Dose-response analysis of short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in three differentially susceptible rat lines. Toxicol. Appl. Pharmacol. 187, 128-136.
18. Tofilon, P. J., and Piper, W. N. (1982). 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated depression of rat testicular heme synthesis and microsomal cytochrome P-450. Biochem. Pharmacol. 31, 3663-3666.
19. Tuomisto, J. T., Viluksela, M., Pohjanvirta, R., and Tuomisto, J. (1999). The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resistant alleles to different rat lines. Toxicol. Appl. Pharmacol. 155, 71-81.
20. Viluksela, M., Bager, Y., Tuomisto, J. T., Scheu, G., Unkila, M., Pohjanvirta, R., Flodstrom, S., Kosma, V. M., Maki-Paakkanen, J., Vartiainen, T., Klimm, C., Schramm, K. W., Warngard, L., and Tuomisto, J. (2000). Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains. Cancer Res. 60, 6911-6920.