Erythropoietin inhibits basal and stimulated corticotropin-releasing hormone release from the rat hypothalamus via a nontranscriptional mechanism

Endocrinology

Volumn 148, Issue 10, 2007, Pages 4711-4715

  Tringali, Giuseppe ^a   Pozzoli, Giacomo ^a   Lisi, Lucia ^a   Navarra, Pierluigi ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; ERYTHROPOIETIN; POTASSIUM CHLORIDE; VASCULOTROPIN; VERATRIDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; HORMONE RELEASE; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; RNA EXTRACTION; STATISTICAL ANALYSIS; WISTAR RAT;

ANIMALS; CORTICOTROPIN-RELEASING HORMONE; ERYTHROPOIETIN; ERYTHROPOIETIN, RECOMBINANT; GENE EXPRESSION; HUMANS; HYPOTHALAMUS; MALE; POTASSIUM CHLORIDE; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VERATRIDINE;

EID: 34748877140     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0431     Document Type: Article

References (33)

1. Brines ML, Ghezzi P, Keenan S, Agnello D, de Lanerolle NC, Cerami C, Itri LM, Cerami A 2000 Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97:10526-10531
2. Masuda S, Okano M, Yamagishi K, Nagao M, Ueda M, Sasaki R 1994 A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 269:19488-19493
3. Morishita E, Masuda S, Nagao M, Yasuda Y, Sasaki R 1997 Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76:105-116
4. Nagai A, Nakagawa E, Choi HB, Hatori K, Kobayashi S, Kim SU 2001 Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol 60:386-392
5. Sakanaka M, Wen TC, Matsuda S, Masuda S, Morishita E, Nagao M, Sasaki R 1998 In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95:4635-4640
6. Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, Mennini T, Heumann R, Cerami A, Ehrenreich H, Ghezzi P 2001 Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98:4044-4049
7. Agnello D, Bigini P, Villa P, Mennini T, Cerami A, Brines ML, Ghezzi P 2002 Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Res 952:128-134
8. Vairano M, Dello Russo C, Pozzoli G, Battaglia A, Scambia G, Tringali G, Aloe-Spiriti MA, Preziosi P, Navarra P 2002 Erythropoietin exerts anti-apoptotic effects on rat microglial cells in vitro. Eur J Neurosci 16:584-592
9. Digicaylioglu M, Lipton SA 2001 Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades. Nature 412:641-647
10. Villa P, Bigini P, Mennini T, Agnello D, Laragione T, Cagnotto A, Viviani B, Marinovich M, Cerami A, Coleman TR, Brines M, Ghezzi P 2003 Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med 198:971-975
11. Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, Savino C, Bianchi M, Nielsen J, Gerwien J, Kallunki P, Larsen AK, Helboe L, Christensen S, Pedersen LO, Nielsen M, Torup L, Sager T, Sfacteria A, Erbayraktar S, Erbayraktar Z, Gokmen N, Yilmaz O, Cerami-Hand C, Xie QW, Coleman T, Cerami A, Brines M 2004 Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305:239-242
12. Greenberg DA, Jin K 2005 From angiogenesis to neuropathology. Nature 438:954-959
13. Ferrara N, Davis-Smith T 1997 The biology of vascular endothelial growth factor. Endocr Rev 18:4-25
14. Ferrara N, Gerber H-P, LeCouter J 2003 The biology of VEGF and its receptors. Nat Med 9:669-676
15. Martinez-Estrada OM, Rodriguez-Millan E, Gonzalez-De Vicente E, Reina M, Vilaro S, Fabre M 2003 Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability. Eur J Neurosci 18:2538-2544
16. Bernaudin M, Tang Y, Reilly M, Petit E, Sharp FR 2002 Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem 277:39728-39738
17. Marti HH 2004 Erythropoietin and the hypoxic brain. J Exp Biol 207:3233-3242
18. Fassbender K, Schmidt R, Mossner R, Daffertshofer M, Hennerici M 1994 Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome. Stroke 25:1105-1108
19. Johansson A, Olsson T, Carlberg B, Karlsson K, Fagerlund M 1997 Hypercortisolism after stroke-partly cytokine-mediated? J Neurol Sci 147:43-47
20. Chen XQ, Du JZ, Wang YS 2004 Regulation of hypoxia-induced release of corticotropin-releasing factor in the rat hypothalamus by norepinephrine. Regul Pept 119:221-228
21. Strijbos PJ, Relton JK, Rothwell NJ 1994 Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain. Brain Res 656:405-408
22. Krugers HJ, Knollema S, Kemper RH, Ter Horst GJ, Korf J 1995 Down-regulation of the hypothalamo-pituitary-adrenal axis reduces brain damage and number of seizures following hypoxia/ischaemia in rats. Brain Res 690:41-47
23. Marklund N, Peltonen M, Nilsson TK, Olsson T 2004 Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke. J Intern Med 256:15-21
24. Navarra P, Tsagarakis S, Faria MS, Rees LH, Besser GM, Grossman AB 1991 Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinology 128:37-44
25. Pozzoli G, Tringali G, Dello Russo C, Vairano M, Preziosi P, Navarra P 2001 HIV-1 Gp120 protein modulates corticotropin releasing factor synthesis and release via the stimulation of its mRNA from the rat hypothalamus in vitro: involvement of inducible nitric oxide synthase. J Neuroimmunol 118:268-276
26. Tringali G, Aubry JM, Navarra P, Pozzoli G 2006 Lamotrigine inhibits basal and Na+-stimulated, but not Ca2+-stimulated, release of corticotropin-releasing hormone from the rat hypothalamus. Psychopharmacology (Berl) 188:386-392
27. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
28. Cheung JY, Zhang XQ, Bokvist K, Tillotson DL, Miller BA 1997 Modulation of calcium channels in human erythroblasts by erythropoietin. Blood 89:92-100
29. Chu X, Cheung JY, Barber DL, Birnbaumer L, Rothblum LI, Conrad K, Abrasonis V, Chan YM, Stahl R, Carey DJ, Miller BA 2002 Erythropoietin modulates calcium influx through TRPC2. J Biol Chem 277:34375-34382
30. Tong Q, Chu X, Cheung JY, Conrad K, Stahl R, Barber DL, Mignery G, Miller BA 2004 Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cγ and IP3R. Am J Physiol Cell Physiol 287:C1667-C1678
31. Kawakami M, Sekiguchi M, Sato K, Kozaki S, Takahashi M 2001 Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia. J Biol Chem 276:39469-39475
32. Kokot F, Wiecek A, Grzeszczak W, Klin M 1990 Influence of erythropoietin treatment on function of the pituitary-adrenal axis and somatotropin secretion in hemodialyzed patients. Clin Nephrol 33:241-246
33. Diez JJ, Iglesias P, Sastre J, Gomez-Pan A, Selgas R, Romero JR, Mendez J 1993 Influence of recombinant human erythropoietin treatment on cortisol responses to insulin-induced hypoglycemia in CAPD patients. Adv Perit Dial 9:336-341