-
1
-
-
0028057250
-
Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20
-
Reff ME, Carner K, Chambers KS, et al. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood 1994; 83:435-445.
-
(1994)
Blood
, vol.83
, pp. 435-445
-
-
Reff, M.E.1
Carner, K.2
Chambers, K.S.3
-
2
-
-
0035883071
-
Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenia purpura
-
Stasi R, Pagano A, Stipa E, et al. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenia purpura. Blood 2001; 98:952-957.
-
(2001)
Blood
, vol.98
, pp. 952-957
-
-
Stasi, R.1
Pagano, A.2
Stipa, E.3
-
3
-
-
0036699047
-
Treatment of relapsed idiopathic thrombocytopenic purpura with the anti-CD20 monoclonal antibody rituximab: A pilot study
-
Giagounidis AA, Anhuf J, Schneider P, et al. Treatment of relapsed idiopathic thrombocytopenic purpura with the anti-CD20 monoclonal antibody rituximab: a pilot study. Eur J Haematol 2002; 69:95-100.
-
(2002)
Eur J Haematol
, vol.69
, pp. 95-100
-
-
Giagounidis, A.A.1
Anhuf, J.2
Schneider, P.3
-
4
-
-
13444291163
-
Chronic immune thrombocytopenic purpura in children: Assessment of rituximab treatment
-
Wang J, Wiley JM, Luddy R, et al. Chronic immune thrombocytopenic purpura in children: assessment of rituximab treatment. J Pediatr 2005; 146:217-221.
-
(2005)
J Pediatr
, vol.146
, pp. 217-221
-
-
Wang, J.1
Wiley, J.M.2
Luddy, R.3
-
5
-
-
33645515481
-
-
Bennett CM, Rogers ZR, Dinnamon DD, et al. Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura. Blood 2006; 107:2639-2642. This is the first published trial of rituximab therapy for severe chronic ITP in a pediatric population. This paper is also the first to report rituximab pharmacokinetic data in children.
-
Bennett CM, Rogers ZR, Dinnamon DD, et al. Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura. Blood 2006; 107:2639-2642. This is the first published trial of rituximab therapy for severe chronic ITP in a pediatric population. This paper is also the first to report rituximab pharmacokinetic data in children.
-
-
-
-
6
-
-
33645885906
-
Rituximab in the management of chronic immune thrombocytopenic purpura: An effective and sage therapeutic alternative in refractory patients
-
This retrospective analysis found significantly better overall responses to rituximab in patients who had not undergone splenectomy, were less heavily pretreated and had a shorter duration of ITP
-
Penalver FJ, Jinenez-Yuste V, Almagro M, et al. Rituximab in the management of chronic immune thrombocytopenic purpura: an effective and sage therapeutic alternative in refractory patients. Ann Hematol 2006; 85:400-406. This retrospective analysis found significantly better overall responses to rituximab in patients who had not undergone splenectomy, were less heavily pretreated and had a shorter duration of ITP.
-
(2006)
Ann Hematol
, vol.85
, pp. 400-406
-
-
Penalver, F.J.1
Jinenez-Yuste, V.2
Almagro, M.3
-
7
-
-
34648854408
-
Rituximab is an alternative to splenectomy in adults with chronic immune thrombocytopenic purpura: Results of a multicenter prospective phase 2 study
-
Godeau B, Fain O, Porcher R, et al. Rituximab is an alternative to splenectomy in adults with chronic immune thrombocytopenic purpura: results of a multicenter prospective phase 2 study. Blood 2006; 108:478a.
-
(2006)
Blood
, vol.108
-
-
Godeau, B.1
Fain, O.2
Porcher, R.3
-
8
-
-
14344263817
-
Effect of a single dose of rituximab in chronic immune thrombocytopenic purpura in childhood
-
Taube T, Schmid H, Reinhard H, et al. Effect of a single dose of rituximab in chronic immune thrombocytopenic purpura in childhood. Haematologica 2005; 90:281-283.
-
(2005)
Haematologica
, vol.90
, pp. 281-283
-
-
Taube, T.1
Schmid, H.2
Reinhard, H.3
-
9
-
-
34648844127
-
Single dose of anti-CD20 monoclonal antibody (Rituximab) treatment in adults with refractory immune thrombocytopenic purpura
-
Tanaka E, Hayashi S, Fujimaki K, et al. Single dose of anti-CD20 monoclonal antibody (Rituximab) treatment in adults with refractory immune thrombocytopenic purpura. Blood 2006; 108:1077a.
-
(2006)
Blood
, vol.108
-
-
Tanaka, E.1
Hayashi, S.2
Fujimaki, K.3
-
10
-
-
34547136792
-
Long term follow-up of patients with immune thrombocytopenic purpura (ITP) whose initial response to rituximab lasted a minimum of one year
-
Patel V, Mihatov N, Cooper N, et al. Long term follow-up of patients with immune thrombocytopenic purpura (ITP) whose initial response to rituximab lasted a minimum of one year. Blood 2006; 108:479a.
-
(2006)
Blood
, vol.108
-
-
Patel, V.1
Mihatov, N.2
Cooper, N.3
-
11
-
-
33846918681
-
Systematic review: Efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura
-
Arnold DM, Dentali F, Crowther MA, et al. Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura. Ann Intern Med 2007; 146:25-33.
-
(2007)
Ann Intern Med
, vol.146
, pp. 25-33
-
-
Arnold, D.M.1
Dentali, F.2
Crowther, M.A.3
-
12
-
-
0346881171
-
-
Broudy VC, Lin HL. AMG 531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokine 2004; 25:52-60.
-
Broudy VC, Lin HL. AMG 531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokine 2004; 25:52-60.
-
-
-
-
13
-
-
0037100423
-
Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
-
Nomura S, Dan K, Hotta T, et al. Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 2002; 100:728-730.
-
(2002)
Blood
, vol.100
, pp. 728-730
-
-
Nomura, S.1
Dan, K.2
Hotta, T.3
-
14
-
-
0035760892
-
Thrombocytopenia caused by the development of antibodies to thrombopoietin
-
Li J, Yang C, Xia Y, et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 2001; 98:3241-3248.
-
(2001)
Blood
, vol.98
, pp. 3241-3248
-
-
Li, J.1
Yang, C.2
Xia, Y.3
-
15
-
-
0036530040
-
Development of panctyopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
-
Basser RL, O'Flaherty E, Green M, et al. Development of panctyopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood 2002; 99:2599-2602.
-
(2002)
Blood
, vol.99
, pp. 2599-2602
-
-
Basser, R.L.1
O'Flaherty, E.2
Green, M.3
-
16
-
-
33748505970
-
The novel thrombopoietic agent AMG 531 is effective in preclinical models of chemo/radiotherapy induced thrombocytopenia
-
Hartley C, McElroy T, Molineux G, et al. The novel thrombopoietic agent AMG 531 is effective in preclinical models of chemo/radiotherapy induced thrombocytopenia. Proc Am Assoc Cancer Res 2005; 46:1233.
-
(2005)
Proc Am Assoc Cancer Res
, vol.46
, pp. 1233
-
-
Hartley, C.1
McElroy, T.2
Molineux, G.3
-
17
-
-
10044296968
-
Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
-
Wang B, Nichol JL, Sullivan JT. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004; 76:628-638.
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 628-638
-
-
Wang, B.1
Nichol, J.L.2
Sullivan, J.T.3
-
18
-
-
0034655649
-
A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia
-
Schiffer CA, Miller K, Larson RA, et al. A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood 2000; 95:2530-2535.
-
(2000)
Blood
, vol.95
, pp. 2530-2535
-
-
Schiffer, C.A.1
Miller, K.2
Larson, R.A.3
-
19
-
-
33750051618
-
-
Newland A, Caulier MT, Kapper-Klunne M, et al. An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura. Br J Haematol 2006; 135:547-553. This phase 1/2 study established the safety and tolerability of subcutaneous AMG531. Efficacy was highest in patients with dose equivalents of >1 μg/kg.
-
Newland A, Caulier MT, Kapper-Klunne M, et al. An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura. Br J Haematol 2006; 135:547-553. This phase 1/2 study established the safety and tolerability of subcutaneous AMG531. Efficacy was highest in patients with dose equivalents of >1 μg/kg.
-
-
-
-
20
-
-
33750035507
-
-
Bussel JB, Kuter DH, George JN, et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med 2006; 355:1672-1681. This phase 1/2 randomized, placebo-controlled clinical trial demonstrated that extended weekly dosing of AMG531 is tolerable and capable of producing sustained platelet responses.
-
Bussel JB, Kuter DH, George JN, et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med 2006; 355:1672-1681. This phase 1/2 randomized, placebo-controlled clinical trial demonstrated that extended weekly dosing of AMG531 is tolerable and capable of producing sustained platelet responses.
-
-
-
-
21
-
-
33947096577
-
Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update
-
Kuter D, Bussel J, George J, et al. Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update. Blood 2006; 108:476a.
-
(2006)
Blood
, vol.108
-
-
Kuter, D.1
Bussel, J.2
George, J.3
-
22
-
-
34648858583
-
Analysis of health-related quality of life in patients receiving AMG 531 using the disease-specific immune thrombocytopenic purpura patient assessment questionnaire
-
George JN, Bussel JB, McMillan R, et al. Analysis of health-related quality of life in patients receiving AMG 531 using the disease-specific immune thrombocytopenic purpura patient assessment questionnaire. Blood 2006; 108:3292a.
-
(2006)
Blood
, vol.108
-
-
George, J.N.1
Bussel, J.B.2
McMillan, R.3
-
23
-
-
34648839858
-
-
Aledort LM, Lyons RM, Okano G, Leveque J. Retrospective matched cohort study of immune thrombocytopenic purpura (ITP): complications related to corticosteroid (CS) use. Blood 2006; 108:3295a. This retrospective claims analysis on over 40 000 corticosteroid users clearly identifies a dose-response relationship to corticosteroid use in ITP patients and the development of serious complications.
-
Aledort LM, Lyons RM, Okano G, Leveque J. Retrospective matched cohort study of immune thrombocytopenic purpura (ITP): complications related to corticosteroid (CS) use. Blood 2006; 108:3295a. This retrospective claims analysis on over 40 000 corticosteroid users clearly identifies a dose-response relationship to corticosteroid use in ITP patients and the development of serious complications.
-
-
-
-
24
-
-
0028358131
-
Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy
-
Andersen JC. Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy. N Engl J Med 1994; 330:1560-1564.
-
(1994)
N Engl J Med
, vol.330
, pp. 1560-1564
-
-
Andersen, J.C.1
-
25
-
-
0041429528
-
Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone
-
Cheng Y, Wong RS, Soo YO, et al. Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone. N Engl J Med 2003; 349:831-836.
-
(2003)
N Engl J Med
, vol.349
, pp. 831-836
-
-
Cheng, Y.1
Wong, R.S.2
Soo, Y.O.3
-
26
-
-
33846925496
-
-
Mazzucconi MG, Fazi P, Bernasconi S, et al. Therapy with high-dose (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience. Blood 2007; 109:1401-1407. This multicenter prospective study confirms the findings of Andersen [24] and Cheng et al. [25] that initial therapy with high-dose dexamethasone in ITP patients is efficacious. The GIMEMA findings suggest that at least three cycles of therapy are necessary for response durability.
-
Mazzucconi MG, Fazi P, Bernasconi S, et al. Therapy with high-dose (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience. Blood 2007; 109:1401-1407. This multicenter prospective study confirms the findings of Andersen [24] and Cheng et al. [25] that initial therapy with high-dose dexamethasone in ITP patients is efficacious. The GIMEMA findings suggest that at least three cycles of therapy are necessary for response durability.
-
-
-
-
27
-
-
0030730311
-
Oral dexamethasone therapy for chronic immune thrombocytopenic purpura: Home run or base hit?
-
Beardsley DS. Oral dexamethasone therapy for chronic immune thrombocytopenic purpura: home run or base hit? J Pediatr 1997; 130:1-2.
-
(1997)
J Pediatr
, vol.130
, pp. 1-2
-
-
Beardsley, D.S.1
-
28
-
-
0021266552
-
Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies [anti-Rh0 (D)]
-
Salama A, Kiefel V, Amberg R, Mueller-Eckhardt C. Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies [anti-Rh0 (D)]. Blut 1984; 49:29-35.
-
(1984)
Blut
, vol.49
, pp. 29-35
-
-
Salama, A.1
Kiefel, V.2
Amberg, R.3
Mueller-Eckhardt, C.4
-
29
-
-
0028100277
-
Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura
-
Blanchette C, Imbach P, Andrew M, et al. Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura. Lancet 1994; 344:703-707.
-
(1994)
Lancet
, vol.344
, pp. 703-707
-
-
Blanchette, C.1
Imbach, P.2
Andrew, M.3
-
30
-
-
31144479365
-
Randomized trial of anti-D immunoglobulin versus low-dose intravenous immunoglobulin in the treatment of childhood chronic idiopathic thrombocytopenic purpura
-
El Alfy MS, Mokhtar GM, El-Laboudy MA, et al. Randomized trial of anti-D immunoglobulin versus low-dose intravenous immunoglobulin in the treatment of childhood chronic idiopathic thrombocytopenic purpura. Acta Haematol 2006; 115:46-52.
-
(2006)
Acta Haematol
, vol.115
, pp. 46-52
-
-
El Alfy, M.S.1
Mokhtar, G.M.2
El-Laboudy, M.A.3
-
31
-
-
0034744562
-
A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura
-
Newman GC, Novoa MV, Fodero EM, et al. A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura. Br J Haematol 2001; 112:1076-1078.
-
(2001)
Br J Haematol
, vol.112
, pp. 1076-1078
-
-
Newman, G.C.1
Novoa, M.V.2
Fodero, E.M.3
-
32
-
-
0034656023
-
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(0)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients
-
Gaines AR. Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(0)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. Blood 2000; 95:2523-2529.
-
(2000)
Blood
, vol.95
, pp. 2523-2529
-
-
Gaines, A.R.1
-
33
-
-
23944470406
-
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura
-
Gaines AR. Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura. Blood 2005; 106:1532-1537.
-
(2005)
Blood
, vol.106
, pp. 1532-1537
-
-
Gaines, A.R.1
-
34
-
-
0035150960
-
Severe acute renal failure due to hemoglobinuria after use of WinRho for the treatment of idiopathic thrombocytopenic purpura
-
Roberti I, Bagtas JF, Reisman L, et al. Severe acute renal failure due to hemoglobinuria after use of WinRho for the treatment of idiopathic thrombocytopenic purpura. Clin Pediatr (Phila) 2001; 40:61-62.
-
(2001)
Clin Pediatr (Phila)
, vol.40
, pp. 61-62
-
-
Roberti, I.1
Bagtas, J.F.2
Reisman, L.3
-
35
-
-
34648844126
-
Cost-minimization analysis of anti-D immune globulin versus intravenous immune globulin for the initial treatment of immune thrombocytopenic purpura
-
Wetzel DA, Tarantino MD. Cost-minimization analysis of anti-D immune globulin versus intravenous immune globulin for the initial treatment of immune thrombocytopenic purpura. Blood 2006; 108:3305a.
-
(2006)
Blood
, vol.108
-
-
Wetzel, D.A.1
Tarantino, M.D.2
-
36
-
-
33748501918
-
Replacement of intravenous administration of anti-D by subcutaneous administration in patients with autoimmune thrombocytopenia
-
Meyer O, Kiesewetter H, Hermsen M, et al. Replacement of intravenous administration of anti-D by subcutaneous administration in patients with autoimmune thrombocytopenia. Pediatr Blood Cancer 2006; 47: 721-722.
-
(2006)
Pediatr Blood Cancer
, vol.47
, pp. 721-722
-
-
Meyer, O.1
Kiesewetter, H.2
Hermsen, M.3
-
37
-
-
33646521038
-
-
Tarantino MD, Young G, Bertolone SJ, et al. Single dose of anti-D immune globulin at 75ug/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children. J Pediatr 2006; 148:489-494. This randomized study in children demonstrates head to head that intravenous anti-D immunoglobulin (at doses of 75 μg/kg) is as effective as high-dose IVIg, confirming the 2001 study by Newman et al. [31] in adults.
-
Tarantino MD, Young G, Bertolone SJ, et al. Single dose of anti-D immune globulin at 75ug/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children. J Pediatr 2006; 148:489-494. This randomized study in children demonstrates head to head that intravenous anti-D immunoglobulin (at doses of 75 μg/kg) is as effective as high-dose IVIg, confirming the 2001 study by Newman et al. [31] in adults.
-
-
-
-
38
-
-
34249719511
-
-
Jenkins JM, Williams D, Deng Y, et al. Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007; 109:4739-4741. This is the first report (in normal volunteers) of the use, including dosing, of eltrombopag.
-
Jenkins JM, Williams D, Deng Y, et al. Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007; 109:4739-4741. This is the first report (in normal volunteers) of the use, including dosing, of eltrombopag.
-
-
-
-
39
-
-
33947096577
-
Analysis of bleeding in patients with immune thrombocytopenicpurpura (ITP):a randomized,double-blind, placebo-controlled trial of eltrombopag, an oral platelet growth factor
-
Bussel JB, Cheng G, Saleh M, et al. Analysis of bleeding in patients with immune thrombocytopenicpurpura (ITP):a randomized,double-blind, placebo-controlled trial of eltrombopag, an oral platelet growth factor. Blood 2006; 108:475a.
-
(2006)
Blood
, vol.108
-
-
Bussel, J.B.1
Cheng, G.2
Saleh, M.3
-
40
-
-
34648847269
-
Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers
-
Desjardins RE, Tempel DL, Lucek R, Kuter DJ. Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers. Blood 2006; 108:477a.
-
(2006)
Blood
, vol.108
-
-
Desjardins, R.E.1
Tempel, D.L.2
Lucek, R.3
Kuter, D.J.4
|