cAMP regulates vegetative growth and cell cycle in Candida albicans

Molecular and Cellular Biochemistry

Volumn 304, Issue 1-2, 2007, Pages 331-341

  Singh, Ajay ^a   Sharma, Sadhna ^a   Khuller, Gopal K ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

cAMP signaling; Candida albicans; Cell cycle; Flow cytometry

Indexed keywords

AMINOPHYLLINE; ATROPINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN G1; PHOSPHODIESTERASE INHIBITOR; TRIFLUOPERAZINE;

ARTICLE; CANDIDA ALBICANS; CELL CYCLE; CELL CYCLE PROGRESSION; CULTURE MEDIUM; ENZYME ACTIVITY; FUNGAL CELL; FUNGAL STRAIN; FUNGUS GROWTH; MORPHOGENESIS; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION;

AMINOPHYLLINE; ATROPINE; CANDIDA ALBICANS; CELL CYCLE; CELL PROLIFERATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; SIGNAL TRANSDUCTION; TRIFLUOPERAZINE;

CANDIDA ALBICANS;

EID: 34648816990     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9516-4     Document Type: Article

References (35)

1. Calderone RA, Fonzi WA (2001) Virulence factors of Candida albicans. Trends Microbiol 9:327-335
2. Lo HJ, Kohler JR, DiDomenico B et al (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90:939-949
3. Saville SP, Lazzell AL, Monteagudo C et al (2003) Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot Cell 2:1053-1060
4. Lengeler KB, Davidson RC, D'Souza C et al (2000) Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev 64:746-785
5. D'Souza CA, Heitman J (2001) Conserved cAMP signaling cascades regulate fungal development and virulence. FEMS Microbiol Rev 25:349-364
6. Rocha CR, Schroppel K, Harcus D et al (2001) Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol Biol Cell 12:3631-3643
7. Harcus D, Nantel A, Marcil A et al (2004) Transcriptional profiling of cyclic AMP signaling in Candida albicans. Mol Biol Cell 15:4490-4499
8. Bahn Y, Sundstrom P (2001) CAP1, an adenylate cyclase-associated protein gene, regulates bud-hyphae transitions, filamentous growth and cyclic AMP levels and is required for virulence of Candida albicans. J Bacteriol 183:3211-3223
9. Cassola A, Parrot M, Silberstein S et al (2004) Candida albicans lacking the gene encoding the regulatory subunit of protein kinase A displays a defect in hyphal formation and an altered localization of the catalytic subunit. Eukaryot Cell 3:190-199
10. Bockmuhl DP, Krishnamurthy S, Gerads M et al (2001) Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans. Mol Microbiol 42:1243-1257
11. Jain P, Akula I, Edlind T (2003) Cyclic AMP signaling pathway modulates susceptibility of Candida s pecies and Saccharomyces cerevisiae to antifungal azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother 47:3195-3201
12. Hochstrasser M, Nelson DL (1989) Cyclic AMP-dependent protein kinase in Paramecium tetraurelia. Its purification and the production of monoclonal antibodies against both subunits. J Biol Chem 264:14510-14518
13. Roskoski R Jr (1983) Assays of protein kinase. Methods Enzymol 99:3-6
14. Sharma S, Kaur H, Khuller GK (2001) Cell cycle effects of phenothiazines: Trifluoperazine and chlorpromazine in Candida albicans. FEMS Microbiol Lett 199:185-190
15. Eilam Y, Chernichovsky D (1988) Low concentrations of trifluoperazine arrest the cell division cycle of Saccharomyces cerevisiae at two specific stages. J Gen Microbiol 134:1063-1069
16. Collart MA, Oliviero S (2002) Saccharomyces cerevisiae. In: Ausbel FM, Brent R, Kington RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds) Current protocols in molecular biology, vol 2. John Wiley and Sons Inc., New York, pp 45-46
17. Sabie FT, Gadd GM (1992) Effect of nucleosides and nucleotides and the relationship between cellular adenosine 3′:5′-cyclic monophosphate (cyclic AMP) and germ tube formation in Candida albicans. Mycopathologia 119:147-156
18. Ogawa R, Streiff MB, Bugayenko A et al (2002) Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells. Blood 99:3390-3397
19. Bindra A, Khuller GK (1992) Correlation between intracellular cAMP levels and phospholipids of Microsporum gypseum. Biochim Biophys Acta 1124:185-189
20. Keymeulen AV, Deleu S, Bartek J et al (2001) Respective roles of carbamylcholine and cyclic adenosine monophosphate in their synergistic regulation of cell cycle in thyroid primary cultures. Endocrinology 142:1251-1259
21. Hu X, Lu JX (2005) The effect of acetylcholine and atropine on proliferation and differentiation and mAchR1 expression of human SK-N-SH cells. Shi Yan Sheng Wu Xue Bao 38:287-296 (Article in Chinese)
22. Shin SY, Kim CG, Hong DD et al (2004) Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells. Exp Mol Med 36:380-386
23. Thevelein JM, de Winde JH (1999) Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol 33:904-918
24. Choi W, Dean RA (1997) The adenylate cyclase gene MAC1 of Magnaporthe grisea controls appressorium formation and other aspects of growth and development. Plant Cell 9:1973-1983
25. Eilam Y, Placheck L, Ben-Gigi G et al (1987) Activity of phenothiazines against medically important yeasts. Antimicrob Agents Chemother 31:834-836
26. Mishra P, Bolard J, Prasad R (1992) Emerging role of lipids of Candida albicans, a pathogenic dimorphic yeast. Biochim Biophys Acta 1127:1-14
27. Muller D, Exler S, Aguilera-Vazquez L, Guerrero-Martin E, Reuss M (2003) Cyclic AMP mediates the cell cycle dynamics of energy metabolism in Saccharomyces cerevisiae. Yeast 20:351-367
28. Sharma RK, Kalra J (1994) Molecular interaction between cAMP and calcium in calmodulin-dependent cyclic nucleotide phosphodiesterase system. Clin Invest Med 17:374-382
29. Cooper DM (2003) Regulation and organization of adenylyl cyclases and cAMP. Biochem J 375:517-529
30. Daniel J (1996) Measuring the toxic effects of high gene dosage on yeast cells. Mol Gen Genet 253:393-396
31. Smith A, Ward MP, Garrett S (1998) Yeast PKA represses Msn2p/ Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation. EMBO J 17:556-564
32. Banno S, Ochiai N, Noguchi R et al (2005) A catalytic subunit of cyclic AMP-dependent protein kinase, PKAC-1, regulates asexual differentiation in Neurospora crassa. Genes Genet Syst 80:25-34
33. Loeb JD, Sepulveda-Becerra M, Hazan I et al (1999) A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans. Mol Cell Biol 49:4019-4027
34. Cvrckova F, Nasmyth K (1993) Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation. EMBO J 12:5277-5286
35. Tokiwa G, Tyers M, Volpe T et al (1994) Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast. Nature 371:342-345