Diffusion model of solute dynamics in a membrane channel: Mapping onto the two-site model and optimizing the flux

Journal of Chemical Physics

Volumn 127, Issue 11, 2007, Pages

  Bezrukov, Sergey M ^a   Berezhkovskii, Alexander M ^b   Szabo, Attila ^c  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL FLOW; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; RATE CONSTANTS; SOLUTE TRANSPORT;

CHANNEL-SOLUTE INTERACTION; DIFFUSION MODELS; INTRACHANNEL POTENTIAL;

DIFFUSION;

ION CHANNEL; SOLVENT;

ARTICLE; BIOLOGICAL MODEL; BIOPHYSICS; CHEMICAL MODEL; CHEMISTRY; DIFFUSION; METHODOLOGY; PHYSICAL CHEMISTRY; PROBABILITY; STATISTICAL MODEL; THEORETICAL MODEL; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; BIOPHYSICS; CHEMISTRY, PHYSICAL; DIFFUSION; ION CHANNELS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, STATISTICAL; MODELS, THEORETICAL; PROBABILITY; SOLVENTS;

EID: 34648813938     PISSN: 00219606     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.2766720     Document Type: Article

References (26)

1. M. Luckey and H. Nikaido, Proc. Natl. Acad. Sci. U.S.A. 77, 167 (1980).
2. R. Benz, A. Schmid, and G. H. Vos-Scheperkeuter, J. Membr. Biol. 100, 21 (1987).
3. T. Ferenci, BioEssays 10, 1 (1989).
4. H. Florke, F. P. Thinnes, H. Winkelbach, Biol. Chem. Hoppe Seyler 375, 513 (1994).
5. R. Dutzler, Y.-F. Wang, P. J. Rizkallah, J. P. Rosenbusch, and T. Schirmer, Structure (London) 4, 127 (1995).
6. C. Andersen, M. Jordy, and R. Benz, J. Gen. Physiol. 105, 385 (1995).
7. T. K. Rostovtseva and S. M. Bezrukov, Biophys. J. 74, 2365 (1998).
8. L. Kullman, M. Winterhalter, and S. M. Bezrukov, Biophys. J. 82, 803 (2002).
9. E. M. Nestorovich, C. Danelon, M. Winterhalter, and S. M. Bezrukov, Proc. Natl. Acad. Sci. U.S.A. 99, 9789 (2002).
10. D. Lu, P. Grayson, and K. Schulten, Biophys. J. 85, 2977 (2003).
11. C. Danelon, E. M. Nestorovich, M. Winterhalter, M. Ceccarelli, and S. M. Bezrukov, Biophys. J. 90, 1617 (2006).
12. A. H. Delcour, Front. Biosci. 8, 1055 (2003).
13. H. Nikaido, Microbiol. Mol. Biol. Rev. 67, 593 (2003).
14. A. M. Berezhkovskii and S. M. Bezrukov, Biophys. J. 88, L17 (2005).
15. A. M. Berezhkovskii and S. M. Bezrukov, Chem. Phys. 319, 342 (2005).
16. S. M. Bezrukov, A. M. Berezhkovskii, M. A. Pustovoit, and A. Szabo, J. Chem. Phys. 113, 8206 (2000).
17. A. M. Berezhkovskii, M. A. Pustovoit, and S. M. Bezrukov, J. Chem. Phys. 116, 9952 (2002).
18. A. M. Berezhkovskii, M. A. Pustovoit, and S. M. Bezrukov, J. Chem. Phys. 119, 3943 (2003).
19. A. B. Kolomeisky, Phys. Rev. Lett. 98, 048105 (2007).
20. P. E. Klebba, Res. Microbiol. 153, 417 (2002).
21. A. Szabo, K. Schulten, and Z. Schulten, J. Chem. Phys. 72, 4350 (1980).
22. S. Redner, A Guide to First-Passage Processes (Cambridge University Press, New York, 2001).
23. F. Kamp and A. Szabo, Cell Biophys. 12, 145 (1988).
24. W. R. Bauer and W. Nadler, Proc. Natl. Acad. Sci. U.S.A. 103, 11446 (2006).
25. T. L. Hill, Proc. Natl. Acad. Sci. U.S.A. 72, 4918 (1975).
26. O. K. Dudko, A. M. Berezhkovskii, and G. H. Weiss, J. Chem. Phys. 121, 1562 (2004).