Structure and function of embryonic rat retinal sheet transplants

Current Eye Research

Volumn 32, Issue 9, 2007, Pages 781-789

  Peng, Qing ^a,b   Thomas, Biju B ^b,e   Aramant, Robert B ^c   Chen, Zhenhai ^b   Sadda, Srinivas R ^b   Seiler, Magdalene J ^b,d  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c University of Louisville School of Medicine   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Human placental alkaline phosphatase; Retinal degeneration; Retinal transplantation; Superior colliculus; Ultrastructure

Indexed keywords

ALKALINE PHOSPHATASE PLACENTA ISOENZYME;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; EMBRYO; EMBRYO POLARITY; EMBRYONIC STRUCTURES; HISTOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; PERINATAL PERIOD; PHOTORECEPTOR; PHOTOSTIMULATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA; RETINA DEGENERATION; ROSETTE FORMATION; SUPERIOR COLLICULUS;

ALKALINE PHOSPHATASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ELECTROPHYSIOLOGY; FETAL TISSUE TRANSPLANTATION; GRAFT SURVIVAL; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; PHOTIC STIMULATION; PHOTORECEPTORS, VERTEBRATE; PLACENTA; RATS; RATS, MUTANT STRAINS; RETINA; RETINAL DEGENERATION; ROD OUTER SEGMENTS; SUPERIOR COLLICULI; TISSUE DONORS; TRANSPLANTS; VISUAL PERCEPTION;

EID: 34548850929     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680701530597     Document Type: Article

References (53)

1. Algvere PV, Berglin L, Gouras P, Sheng Y, Kopp ED. Transplantation of RPE in age-related macular degeneration: observations in disciform lesions and dry RPE atrophy. Graefes Archi Clin Exp Ophthalmol. 1997;235:149-158.
2. Juliusson B, Bergström A, van Veen T, Ehinger B. Cellular organization in retinal transplants using cell suspensions or fragments of embryonic retinal tissue. Cell Transplant. 1993;2:411-418.
3. Li L, Turner JE. Optimal conditions for long-term photoreceptor cell rescue in RCS rats: the necessity for healthy RPE transplants. Exp Eye Res. 1991;52:669-679.
4. Aramant RB, Seiler MJ, Ehinger B, Bergström A, Adolph AR, Turner JE. Neuronal markers in rat retinal grafts. Dev. Brain Res. 1990;53:47-61.
5. Del Cerro M, Ison JR, Bowen GP, Lazar E, Del Cerro C. Intraretinal grafting restores function in light-blinded rats. NeuroReport. 1991;2:529-532.
6. Gouras P, Du J, Kjeldbye H, Yamamoto S, Zack DJ. Long-term photoreceptor transplants in dystrophic and normal mouse retina. Invest Ophthalmol Vis Sci. 1994;35:3145-3153.
7. Kwan AS, Wang S, Lund RD. Photoreceptor layer reconstruction in a rodent model of retinal degeneration. Exp Neurol. 1999;159:21-33.
8. Seiler M, Aramant R. Transplantation of embryonic retinal donor cells labelled with BrdU or carrying a genetic marker to adult retina. Exp Brain Res. 1995;105:59-66.
9. Berger AS, Tezel TH, Del Priore LV, Kaplan HJ. Photoreceptor transplantation in retinitis pigmentosa: short-term follow-up. Ophthalmology. 2003;110:383-391.
10. Kaplan HJ, Tezel TH, Berger AS, Wolf ML, Del Priore LV. Human photoreceptor transplantation in retinitis pigmentosa. A safety study. Arch Ophthalmol. 1997;115:1168-1172.
11. Silverman MS, Hughes SE, Valentino T, Liu Y. Photoreceptor transplantation: Anatomic, electrophysiologic, and behavioral evidence for the functional reconstruction of retinas lacking photoreceptors. Exp Neurol. 1992;115:87-94.
12. Ghosh F, Wong F, Johansson K, Bruun A, Petters RM. Transplantation of full-thickness retina in the rhodopsin transgenic pig. Retina. 2004;24:98-109.
13. Sagdullaev BT, Aramant RB, Seiler MJ, Woch G, McCall MA. Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2003;44:1686-1695.
14. Seiler MJ, Aramant RB. Intact sheets of fetal retina transplanted to restore damaged rat retinas. Invest Ophthalmol Vis Sci. 1998;39:2121-2131.
15. Seiler MJ, Aramant RB. Transplantation of neuroblastic progenitor cells as a sheet preserves and restores retinal function. Semin Ophthalmol. 2005;20:31-42.
16. Ali RR. Prospects for gene therapy. Novartis Found Symp. 2004;255:165-72; discussion 173-178.
17. Dejneka NS, Rex TS, Bennett J. Gene therapy and animal models for retinal disease. Dev Ophthalmol. 2003;37:188-198.
18. Delyfer MN, Leveillard T, Mohand-Said S, Hicks D, Picaud S, Sahel JA. Inherited retinal degenerations: therapeutic prospects. Biol Cell. 2004;96:261-269.
19. Loewenstein JI, Montezuma SR, Rizzo JF, 3rd Outer retinal degeneration: an electronic retinal prosthesis as a treatment strategy. Arch Ophthalmol. 2004;122:587-596.
20. Margalit E, Maia M, Weiland JD, et al. Retinal prosthesis for the blind. Surv Ophthalmol. 2002;47:335-356.
21. Rizzo JF, 3rd, Wyatt J, Humayun M, et al. Retinal prosthesis: an encouraging first decade with major challenges ahead. Ophthalmology. 2001;108:13-14.
22. Weiland JD, Liu W, Humayun MS. Retinal prosthesis. Annu Rev Biomed Eng. 2005;7:361-401.
23. Caffe AR, Soderpalm AK, Holmqvist I, van Veen T. A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal explants. Invest Ophthalmol Vis Sci. 2001;42:275-282.
24. Chong NH, Bird AC. Management of inherited outer retinal dystrophies: present and future. Br J Ophthalmol. 1999;83:120-122.
25. Sauvé Y, Girman SV, Wang S, Lawrence JM, Lund RD. Progressive visual sensitivity loss in the Royal College of Surgeons rat: perimetric study in the superior colliculus. Neuroscience. 2001;103:51-63.
26. Thomas BB, Aramant RB, Sadda SR, Seiler MJ. Retinal transplantation - a treatment strategy for retinal degenerative diseases. In: Hollyfield JG, Anderson RE, LaVail MM, Retinal Degenerative Diseases. New York: Springer: 2006:367-376.
27. Thomas BB, Seiler MJ, Sadda SR, Aramant RB. Superior colliculus responses to light - preserved by transplantation in a slow degeneration rat model. Exp Eye Res. 2004;79:29-39.
28. Algvere PV, Gouras P, Dafgard Kopp E. Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD. Eur J Ophthalmol. 1999;9:217-230.
29. Das T, del Cerro M, Jalali S, et al.. The transplantation of human fetal neuroretinal cells in advanced retinitis pigmentosa patients: results of a long-term safety study. Exp Neurol. 1999;157:58-68.
30. Radtke ND, Aramant RB, Seiler MJ, Petry HM, Pidwell DJ. Vision change after sheet transplant of fetal retina with RPE to a retinitis pigmentosa patient. Arch Ophthalmol. 2004;122:1159-1165.
31. Radtke ND, Seiler MJ, Aramant RB, Petry HM, Pidwell DJ. Transplantation of intact sheets of fetal neural retina with its retinal pigment epithelium in retinitis pigmentosa patients. Am J Ophthalmol. 2002;133:544-550.
32. Aramant RB, Seiler MJ, Ball SL. Successful cotransplantation of intact sheets of fetal retinal pigment epithelium with retina. Invest Ophthalmol Vis Sci. 1999;40:1557-1564.
33. Seiler MJ, Aramant RB, Ball SL. Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin. Vision Res. 1999;39:2589-2596.
34. Arai S, Thomas BB, Seiler MJ, et al. Restoration of visual responses following transplantation of intact retinal sheets in rd mice. Exp Eye Res. 2004;79:331-341.
35. Woch G, Aramant RB, Seiler MJ, Sagdullaev BT, McCall MA. Retinal transplants restore visually evoked responses in rats with photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2001;42:1669-1676.
36. Kisseberth WC, Brettingen NT, Lohse JK, Sandgren EP. Ubiquitous expression of marker transgenes in mice and rats. Dev Biol. 1999;214:128-138.
37. Mujtaba T, Han SS, Fischer I, Sandgren EP, Rao MS. Stable expression of the alkaline phosphatase marker gene by neural cells in culture and after transplantation into the CNS using cells derived from a transgenic rat. Exp Neurol. 2002;174:48-57.
38. Aramant RB, Seiler MJ. Retinal transplantation - advantages of intact fetal sheets. Prog Retin Eye Res. 2002a;21:57-73.
39. Thomas BB, Aramant RB, Sadda SR, Seiler MJ. Light response differences in the superior colliculus of albino and pigmented rats. Neurosci Lett. 2005;385:143-147.
40. Eldred WD, Zucker C, Karten HJ, Yazulla S. Comparison of fixation and penetration enhancement techniques for use in ultrastructural immunocytochemistry. J Histochem Cytochem. 1983;31:285-292.
41. Seiler MJ, Sagdullaev BT, Woch G, Thomas BB, Aramant RB. Transsynaptic virus tracing from host brain to subretinal transplants. Eur J Neurosci. 2005;21:161-172.
42. Fintz AC, Audo I, Hicks D, Mohand-Said S, Leveillard T, Sahel J. Partial characterization of retina-derived cone neuroprotection in two culture models of photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2003;44:818-825.
43. Mohand-Said S, Hicks D, Dreyfus H, Sahel JA. Selective transplantation of rods delays cone loss in a retinitis pigmentosa model. Arch Ophthalmol. 2000;118:807-811.
44. Ghosh F, Bruun A, Ehinger B. Graft-host connections in long-term full-thickness embryonic rabbit retinal transplants. Invest Ophthalmol Vis Sci. 1999a;40:126-132.
45. Aramant RB, Seiler MJ. Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats. Exp Eye Res. 2002b;75:115-125.
46. Ghosh F, Johansson K, Ehinger B. Long-term full-thickness embryonic rabbit retinal transplants. Invest Ophthalmol Vis Sci. 1999b;40:133-142.
47. Aramant RB, Seiler MJ. Progress in retinal sheet transplantation. Prog Retin Eye Res. 2004;23:475-494.
48. Aramant RB, Seiler MJ. Human embryonic retinal cell transplants in athymic immunodeficient rat hosts. Cell Transplant. 1994;3:461-474.
49. Ehinger B, Bergström A, Seiler M, et al. Ultrastructure of human retinal cell transplants with long survival times in rats. Exp. Eye Res. 1991;53:447-460.
50. Gouras P, Tanabe T. Survival and integration of neural retinal transplants in rd mice. Graefes Arch Clin Exp Ophthalmol. 2003;241:403-409.
51. Guo Y, Saloupis P, Shaw SJ, Rickman DW. Engraftment of adult neural progenitor cells transplanted to rat retina injured by transient ischemia. Invest Ophthalmol Vis Sci. 2003;44:3194-3201.
52. Lai CC, Gouras P, Doi K, et al. Tracking RPE transplants labeled by retroviral gene transfer with green fluorescent protein. Invest Ophthalmol Vis Sci. 1999;40:2141-2146.
53. Mizumoto H, Mizumoto K, Shatos MA, Klassen H, Young MJ. Retinal transplantation of neural progenitor cells derived from the brain of GFP transgenic mice. Vision Res. 2003;43:1699-1708.