Manipulation of thrombin exosite I, by ligand-directed covalent modification

Journal of Thrombosis and Haemostasis

Volumn 5, Issue 10, 2007, Pages 2062-2069

  Yegneswaran, Subramanian ^a   Tiefenbrunn, T K ^a   Fernandez J A ^a   Dawson, P E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Dye transfer; Exosites; Fluorescence; Peptide inhibition; Photocrosslinking; Thrombin

Indexed keywords

CROSS LINKING REAGENT; DESULFATOHIRUGEN DERIVATIVE; FIBRINOGEN; FLUORESCENT DYE; PROTHROMBIN A; THROMBIN; THROMBIN INHIBITOR; THROMBOMODULIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BLOOD CLOTTING; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FIBRINOGEN METABOLISM; FLUORESCENCE ANALYSIS; INHIBITION KINETICS; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS;

BINDING SITES; CROSS-LINKING REAGENTS; FLUORESCENT DYES; HUMANS; LIGANDS; LIGHT; MODELS, CHEMICAL; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEPHAROSE; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; THROMBIN;

EID: 34548850347     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02712.x     Document Type: Article

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