Mutant prion protein D202N associated with familial prion disease is retained in the endoplasmic reticulum and forms 'curly' intracellular aggregates

Journal of Molecular Neuroscience

Volumn 32, Issue 1, 2007, Pages 90-96

  Gu, Yaping ^a   Verghese, Susamma ^a   Bose, Sharmila ^a   Mohan, Maradumane ^a   Singh, Neena ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Curly aggregates; GSS D202N; Inherited disease; Oxidative stress; Prion disorders

Indexed keywords

FREE RADICAL; PRION PROTEIN;

ARTICLE; CELL AGGREGATION; CELL CULTURE; CELL MATURATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NEUROBLASTOMA CELL; NEUROTOXICITY; OXIDATIVE STRESS; PRION DISEASE; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN EXPRESSION;

CELL LINE, TUMOR; DETERGENTS; ENDOPLASMIC RETICULUM; FREE RADICALS; HUMANS; MUTATION; NEUROBLASTOMA; OXIDATIVE STRESS; PRION DISEASES; PRIONS; PROTEIN FOLDING; SOLUBILITY;

ANIMALIA;

EID: 34548848324     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-007-0023-6     Document Type: Article

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