Expression of neurotrophin receptor TrkA inhibits angiogenesis in neuroblastoma

Medical and Pediatric Oncology

Volumn 35, Issue 6, 2000, Pages 569-572

  Eggert, Angelika ^a,b,c   Grotzer, Michael A ^a,d   Ikegaki, Naohiko ^a,b   Liu, Xing Ge ^a,b   Evans, Audrey E ^a,b   Brodeur, Garrett M ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Angiogenesis; bFGF; Neuroblastoma; Tyrosine kinase receptors; VEGF

Indexed keywords

ANGIOGENIC FACTOR; BASIC FIBROBLAST GROWTH FACTOR; NEUROTROPHIN RECEPTOR; TYROSINE KINASE RECEPTOR; VASCULOTROPIN;

ADOLESCENT; ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; CANCER CELL CULTURE; CARCINOGENICITY; CELL PROLIFERATION; CONFERENCE PAPER; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NEUROBLASTOMA; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VASCULARIZATION;

CELL DIVISION; ENDOTHELIAL GROWTH FACTORS; FIBROBLAST GROWTH FACTOR 2; HUMANS; LYMPHOKINES; NEOVASCULARIZATION, PATHOLOGIC; NEUROBLASTOMA; PHOSPHORYLATION; PROTEIN ISOFORMS; RECEPTOR, TRKA; RECEPTOR, TRKB; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033653735     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-911X(20001201)35:6<569::AID-MPO16>3.0.CO;2-A     Document Type: Conference Paper

References (16)

1. What is the evidence that tumors are angiogenesis dependent?
2. Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival
3. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
4. Transforming growth factor-α-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation
5. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
6. Association between high levels of expression of the Trk gene and favorable outcome in human neuroblastomas
7. Expression and function of Trk-B and BDNF in human neuroblastomas
8. Transfection of TrkA into human neuroblastoma cells restores their ability to differentiate in response to NGF
9. High level expression of angiogenic factors is associated with advanced tumor stage in human NB
10. Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma
11. Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells
12. A relative quantitative RT-PCR protocol for TrkB expression in neuroblastoma using GAPD as an internal control
13. Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
14. TrkA expression decreases the in vivo aggressiveness of C6 glioma cells
15. Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression
16. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo