Mechanisms underlying postoperative nausea and vomiting and neurotransmitter receptor antagonist-based pharmacotherapy

CNS Drugs

Volumn 21, Issue 10, 2007, Pages 813-833

  Gan, Tong J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; APREPITANT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; DEXAMETHASONE; DIMENHYDRINATE; DOLASETRON MESILATE; DOPAMINE RECEPTOR BLOCKING AGENT; DROPERIDOL; GRANISETRON; HALOPERIDOL; INHALATION ANESTHETIC AGENT; METOCLOPRAMIDE; NEOSTIGMINE; NEUROTRANSMITTER RECEPTOR; NITROUS OXIDE; ONDANSETRON; OPIATE ANTAGONIST; OPIATE DERIVATIVE; PROCHLORPERAZINE; PROMETHAZINE; SCOPOLAMINE; SEROTONIN ANTAGONIST; TACHYKININ RECEPTOR ANTAGONIST; TRAMADOL; TROPISETRON; UNINDEXED DRUG; VOFOPITANT;

ABDOMINAL PAIN; AGITATION; ANXIETY DISORDER; ASTHENIA; ATAXIA; AVASCULAR NECROSIS; BLURRED VISION; CENTRAL NERVOUS SYSTEM DEPRESSION; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONFUSION; CONSTIPATION; DIARRHEA; DISORIENTATION; DIZZINESS; DROWSINESS; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FATALITY; DRUG MECHANISM; DRUG MEGADOSE; DRUG RECEPTOR BINDING; DRUG TOLERABILITY; EUPHORIA; EXTRAPYRAMIDAL SYMPTOM; GASTROINTESTINAL SYMPTOM; HALLUCINATION; HEADACHE; HEART ARRHYTHMIA; HEART INFARCTION; HIGH RISK PATIENT; HOT FLUSH; HUMAN; HYPERGLYCEMIA; HYPOTENSION; IMMUNE DEFICIENCY; INSOMNIA; LETHARGY; MEMORY DISORDER; META ANALYSIS; MONOTHERAPY; MYALGIA; NEUROLEPTIC MALIGNANT SYNDROME; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; QT PROLONGATION; RESTLESSNESS; REVIEW; RISK FACTOR; SEDATION; SIDE EFFECT; SOMNOLENCE; SUPRAVENTRICULAR TACHYCARDIA; SYSTEMATIC REVIEW; TORSADE DES POINTES; TREATMENT RESPONSE; URINE RETENTION; XEROSTOMIA;

ANIMALS; DRUG THERAPY; HUMANS; META-ANALYSIS AS TOPIC; MODELS, BIOLOGICAL; POSTOPERATIVE NAUSEA AND VOMITING; RECEPTORS, NEUROTRANSMITTER;

EID: 34548842529     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200721100-00003     Document Type: Review

References (70)

1. Visser K, Hassink EA, Bonsel GJ, et al. Randomized controlled trial of total intravenous anesthesia with propofol versus inhalation anesthesia with isoflurane-nitrous oxide: postoperative nausea with vomiting and economic analysis. Anesthesiology 2001; 95 (3): 616-26
2. Apfel CC, Laara E, Koivuranta M, et al. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology 1999; 91 (3): 693-700
3. Watcha MF, White PF. Postoperative nausea and vomiting: its etiology, treatment, and prevention. Anesthesiology 1992; 77 (1): 162-84
4. Hill RP, Lubarsky DA, Phillips-Bute B, et al. Cost-effectiveness of prophylactic antiemetic therapy with ondansetron, droperidol, or placebo. Anesthesiology 2000; 92 (4): 958-67
5. Schumann R, Polaner DM. Massive subcutaneous emphysema and sudden airway compromise after postoperative vomiting. Anesth Analg 1999; 89 (3): 796-7
6. Toprak V, Keles GT, Kaygisiz Z, et al. Subcutaneous emphysema following severe vomiting after emerging from general anesthesia. Acta Anaesthesiol Scand 2004; 48 (7): 917-8
7. Zhang GS, Mathura JR. Images in clinical medicine: painless loss of vision after vomiting. N Engl J Med 2005; 352 (17): E16
8. Macario A, Weinger M, Truong P, et al. Which clinical anesthesia outcomes are both common and important to avoid? The perspective of a panel of expert anesthesiologists. Anesth Analg 1999; 88 (5): 1085-91
9. Macario A, Weinger M, Carney S, et al. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg 1999; 89 (3): 652-8
10. Gan T, Sloan F, Dear GL, et al. How much are patients willing to pay to avoid postoperative nausea and vomiting? Anesth Analg 2001; 92 (2): 393-400
11. Apfel CC, Roewer N, Korttila K. How to study postoperative nausea and vomiting. Acta Anaesthesiol Scand 2002; 46 (8): 921-8
12. Habib AS, Gan TJ. Pharmacotherapy of postoperative nausea and vomiting. Expert Opin Pharmacother 2003; 4 (4): 457-73
13. Habib AS, Gan TJ. Evidence-based management of postoperative nausea and vomiting: a review. Can J Anaesth 2004; 51 (4): 326-41
14. Gan TJ, Meyer T, Apfel CC, et al. Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg 2003; 97 (1): 62-71
15. Biedler A, Wermelt J, Kunitz O, et al. A risk adapted approach reduces the overall institutional incidence of postoperative nausea and vomiting. Can J Anaesth 2004; 51 (1): 13-9
16. Apfel CC, Kranke P, Eberhart LH. Comparison of surgical site and patient's history with a simplified risk score for the prediction of postoperative nausea and vomiting. Anaesthesia 2004; 59 (11): 1078-82
17. Pierre S, Corno G, Benais H, et al. A risk score-dependent antiemetic approach effectively reduces postoperative nausea and vomiting: a continuous quality improvement initiative. Can J Anaesth 2004; 51 (4): 320-5
18. Rusch D, Eberhart L, Biedler A, et al. Prospective application of a simplified risk score to prevent postoperative nausea and vomiting. Can J Anaesth 2005; 52 (5): 478-84
19. Eberhart LH, Morin AM, Guber D, et al. Applicability of risk scores for postoperative nausea and vomiting in adults to paediatric patients. Br J Anaesth 2004; 93 (3): 386-92
20. Hornby PJ. Central neurocircuitry associated with emesis. Am J Med 2001; 111 Suppl. 8A: 106-2S
21. Miller AD. Central mechanisms of vomiting. Dig Dis Sci 1999; 44 (8 Suppl.): 39-43S
22. Andrews PL, Naylor RJ, Joss RA. Neuropharmacology of emesis and its relevance to anti-emetic therapy: consensus and controversies. Support Care Cancer 1998; 6 (3): 197-203
23. Miller AD, Nonaka S, Jakus J. Brain areas essential or nonessential for emesis. Brain Res 1994; 647 (2): 255-64
24. Saito R, Takano Y, Kamiya HO. Roles of substance P and NK(1) receptor in the brainstem in the development of emesis. J Pharmacol Sci 2003; 91 (2): 87-94
25. Kojima Y, Takahashi T, Fujina M, et al. Inhibition of cholinergic transmission by opiates in ileal myenteric plexus is mediated by kappa receptor: involvement of regulatory inhibitory G protein and calcium N-channels. J Pharmacol Exp Ther 1994; 268 (2): 965-70
26. Tsuchida D, Fukuda H, Koda K, et al. Central effect of muopioid agonists on antral motility in conscious rats. Brain Res 2004; 1024 (1-2): 244-50
27. Janicki PK. Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit 2005; 11 (10): RA322-328
28. Candiotti KA, Birnbach DJ, Lubarsky DA, et al. The impact of pharmacogenomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis? Anesthesiology 2005; 102 (3): 543-9
29. Arcioni R, Della RM, Romano S, et al. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans. Anesth Analg 2002; 94 (6): 1553-7
30. Hammonds B, Sidebotham DA, Anderson BJ. Aspects of tramadol and ondansetron interactions. Acute Pain 2003; 5: 31-4
31. Scuderi PE. Pharmacology of antiemetics. Int Anesthesiol Clin 2003; 41 (4): 41-66
32. Diemunsch P, Schoeffler P, Bryssine B, et al. Antiemetic activity of the NK1 receptor antagonist GR205171 in the treatment of established postoperative nausea and vomiting after major gynaecological surgery. Br J Anaesth 1999; 82 (2): 274-6
33. Gesztesi Z, Scuderi PE, White PF, et al. Substance P (neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedures. Anesthesiology 2000; 93 (4): 931-7
34. Gan TJ, Apfel CC, Kovac A, et al. A randomized, double-blind comparison of the NK1 antagonist, aprepitant versus ondansetron for the prevention of postoperative nausea and vomiting. Anesth Analg 2007; 104 (5): 1082-9
35. Apfel CC, Korttila K, Abdalla M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004; 350 (24): 2441-51
36. Kranke P, Morin AM, Roewer N, et al. The efficacy and safety of transdermal scopolamine for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 2002; 95 (1): 133-43
37. Kranke P, Morin AM, Roewer N, et al. Dimenhydrinate for prophylaxis of postoperative nausea and vomiting: a meta-analysis of randomized controlled trials. Acta Anaesthesiol Scand 2002; 46 (3): 238-44
38. Henzi I, Walder B, Tramer MR. Metoclopramide in the prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized, placebo-controlled studies. Br J Anaesth 1999; 83 (5): 761-71
39. Domino KB, Anderson EA, Polissar NL, et al. Comparative efficacy and safety of ondansetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting: a meta-analysis. Anesth Analg 1999; 88 (6): 1370-9
40. Hirayama T, Ishii F, Yago K, et al. Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review. Yakugaku Zasshi 2001; 121 (2): 179-85
41. Tramer MR, Moore RA, Reynolds DJ, et al. A quantitative systematic review of ondansetron in treatment of established postoperative nausea and vomiting. BMJ 1997; 314 (7087): 1088-92
42. Figueredo ED, Canosa LG. Ondansetron in the prophylaxis of postoperative vomiting: a meta-analysis. J Clin Anesth 1998; 10 (3): 211-21
43. Figueredo E, Canosa L. Prophylactic ondansetron for postoperative emesis: meta-analysis of its effectiveness in patients with previous history of postoperative nausea and vomiting. Acta Anaesthesiol Scand 1999; 43 (6): 637-44
44. Philip BK, McLeskey CH, Chelly JE, et al. Pooled analysis of three large clinical trials to determine the optimal dose of dolasetron mesylate needed to prevent postoperative nausea and vomiting. The Dolasetron Prophylaxis Study Group. J Clin Anesth 2000; 12 (1): 1-8
45. Eberhart LH, Morin AM, Bothner U, et al. Droperidol and 5-HT3-receptor antagonists, alone or in combination, for prophylaxis of postoperative nausea and vomiting: a meta-analysis of randomised controlled trials. Acta Anaesthesiol Scand 2000; 44 (10): 1252-7
46. Habib AS, El Moalem HE, Gan TJ. The efficacy of the 5-HT3 receptor antagonists combined with droperidol for PONV prophylaxis is similar to their combination with dexamethasone: a meta-analysis of randomized controlled trials. Can J Anaesth 2004; 51 (4): 311-9
47. Leslie JB, Gan TJ. Meta-analysis of the safety of 5-HT3 antagonists with dexamethasone or droperidol for prevention of PONV. Ann Pharmacother 2006; 40 (5): 856-72
48. Kovac AL. Meta-analysis of the use of rescue antiemetics following PONV prophylactic failure with 5HT3 antagonist/dexamethasone versus single-agent therapies. Ann Pharmacother 2006; 40 (5): 873-87
49. Buttner M, Walder B, von Elm E, et al. Is low-dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials. Anesthesiology 2004; 101 (6): 1454-63
50. Henzi I, Walder B, Tramer MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 2000; 90 (1): 186-94
51. Tramer MR, Walder B. Efficacy and adverse effects of prophylactic antiemetics during patient-controlled analgesia therapy: a quantitative systematic review. Anesth Analg 1999; 88 (6): 1354-61
52. Habib AS, Gan TJ. Food and drug administration black box warning on the perioperative use of droperidol: a review of the cases. Anesth Analg 2003; 96 (5): 1377-9
53. Gold BS, Kitz DS, Lecky JH, et al. Unanticipated admission to the hospital following ambulatory surgery. JAMA 1989; 262 (21): 3008-10
54. White PF, Song D, Abrao J, et al. Effect of low-dose droperidol on the QT interval during and after general anesthesia: a placebo-controlled study. Anesthesiology 2005; 102 (6): 1101-5
55. Charbit B, Albaladejo P, Funck-Brentano C, et al. Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. Anesthesiology 2005; 102 (6): 1094-100
56. Scuderi PE. You (still) can't disprove the existence of dragons. Anesthesiology 2005; 102 (6): 1081-2
57. Notification of the Health Products and Food Branch (HPFB) from Health Canada, June 30, 2006 [online]. Available from URL: http://www.hc-sc.gc.ca/dhp- mps/medeff/advisories-avis/prof/2006/anzemet_nth-aah_e.html.2007 [Accessed 2007 Jan 3]
58. Gan TJ, Ginsberg B, Glass PS, et al. Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology 1997; 87 (5): 1075-81
59. Maxwell LG, Kaufmann SC, Bitzer S, et al. The effects of a small-dose naloxone infusion on opioid-induced side effects and analgesia in children and adolescents treated with intravenous patient-controlled analgesia: a double-blind, prospective, randomized, controlled study. Anesth Analg 2005; 100 (4): 953-8
60. Joshi GP, Duffy L, Chehade J, et al. Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. Anesthesiology 1999; 90 (4): 1007-11
61. Taguchi A, Sharma N, Saleem RM, et al. Selective postoperative inhibition of gastrointestinal opioid receptors. N Engl J Med 2001; 345 (13): 935-40
62. Golden GA, Mason PE, Rubin RT, et al. Biophysical membrane interactions of steroid hormones: a potential complementary mechanism of steroid action. Clin Neuropharmacol 1998; 21 (3): 181-9
63. Floman Y, Zor U. Mechanism of steroid action in inflammation: inhibition of prostaglandin synthesis and release. Prostaglandins 1976; 12 (3): 403-13
64. Fujii Y, Tanaka H, Toyooka H. The effects of dexamethasone on antiemetics in female patients undergoing gynecologic surgery. Anesth Analg 1997; 85 (4): 913-7
65. Liu K, Hsu CC, Chia YY. Effect of dexamethasone on postoperative emesis and pain. Br J Anaesth 1998; 80 (1): 85-6
66. Liu K, Hsu CC, Chia YY. The effect of dose of dexamethasone for antiemesis after major gynecological surgery. Anesth Analg 1999; 89 (5): 1316-8
67. Wang JJ, Ho ST, Lee SC, et al. The use of dexamethasone for preventing postoperative nausea and vomiting in females undergoing thyroidectomy: a dose-ranging study. Anesth Analg 2000; 91 (6): 1404-7
68. Wang JJ, Ho ST, Tzeng JI, et al. The effect of timing of dexamethasone administration on its efficacy as a prophylactic antiemetic for postoperative nausea and vomiting. Anesth Analg 2000; 91 (1): 136-9
69. Tramer MR. Rational control of PONV: the rule of three. Can J Anaesth 2004; 51 (4): 283-5
70. Andrews PL, Richards CA, Smith JE. The neurophysiology of emesis: lessons from basic science for understanding paediatric problems. J Pediatr Gastroenterol Nutr 2001; 32 Suppl. 1: S12-13