Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6985-6993

  Brouwer, Arwin J ^a   Bunschoten, Anton ^a   Liskamp, Rob M J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Amino acid; Chloromethyl sulfoxide; Cysteine protease; Irreversible inhibitor; Papain

Indexed keywords

AMINO ACID; CHYMOTRYPSIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; PAPAIN; SERINE PROTEINASE; SULFOXIDE;

ARTICLE; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION;

CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PAPAIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOXIDES;

EID: 34548836319     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.045     Document Type: Article

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