Serotonin concentrations in the lumbosacral spinal cord of the adult rat following microinjection or dorsal surface application

Journal of Neurophysiology

Volumn 98, Issue 3, 2007, Pages 1440-1450

  Brumley, Michele R ^a   Hentall, Ian D ^a   Pinzon, Alberto ^a,b   Kadam, Brijesh H ^a,c   Blythe, Anthony ^a   Sanchez, Francisco J ^a   Taberner, Annette M ^a   Noga, Brian R ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c MARSHFIELD CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON FIBER; CLOMIPRAMINE; HALOTHANE; SEROTONIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; FEMALE; LUMBOSACRAL SPINE; MICROELECTRODE; MICROINJECTION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ANIMALS; CLOMIPRAMINE; ELECTROPHYSIOLOGY; FEMALE; HALOTHANE; INJECTIONS, SPINAL; MICROINJECTIONS; RATS; RATS, INBRED STRAINS; SEROTONIN; SPINAL CORD;

EID: 34548806413     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00309.2007     Document Type: Article

References (54)

1. Antri M, Orsal D, Barthe J-Y. Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist. Eur J Neurosci 16: 467-476, 2002.
2. Armstrong-James M, Millar J. High-speed cyclic voltammetry and unit recording with carbon fibre microelectrodes. In: Measurement of Neurotransmitter Release In Vivo, edited by Marsden CA. Toronto: Wiley, 1984, p. 209-226.
3. Barbeau H, Rossignol S. Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic, and dopaminergic drugs. Brain Res 546: 250-260, 1991.
4. Bardin L, Bardin M, Lavarenne J, Eschalier A. Effect of intrathecal serotonin on nociception in rats: influence of the pain test used. Exp Brain Res 113: 81-87, 1997.
5. Binns BC, Huang Y, Goettl VM, Hackshaw KV, Stephens RL. Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model. Brain Res 1041: 38-47, 2005.
6. Brumley MR, Taberner AM, Blythe AD, Sanchez FJ, Hentall ID, Noga BR. Serotonin and norepinephrine concentrations measured simultaneously at various depths in the lumbar spinal cord of the adult cat following dorsal surface (bath) application. Soc Neurosci Abstr 33: 924.15, 2007.
7. Bunin MA, Wightman RM. Quantitative evaluation of 5-hydroxytryptamine (serotonin) neuronal release and uptake: an investigation of extrasynaptic transmission. J Neurosci 18: 4854-4860, 1998.
8. Cazalets JR, Sqalli-Houssaini Y, Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J Physiol 455: 187-204, 1992.
9. Cina C, Hochman S. Diffuse distribution of sulforhodamine-labeled neurons during serotonin-evoked locomotion in the neonatal rat thoracolumbar spinal cord. J Comp Neurol 422: 590-602, 2000.
10. Clarac F, Pearlstein E, Pflieger J-F, Vinay L. The in vitro rat spinal cord preparation: a new insight into mammalian locomotor mechanisms. J Comp Physiol A Sens Neural Behav Physiol 190: 343-357, 2004.
11. Cowley KC, Schmidt BJ. A comparison of motor patterns induced by N-methyl-D-aspartate, acetylcholine and serotonin in the in vitro neonatal rat spinal cord. Neurosci Lett 171: 147-150, 1994.
12. Crown ED, Grau JW. Evidence that descending serotonergic systems protect spinal cord plasticity against the disruptive effect of uncontrollable stimulation. Exp Neurol 196: 164-176, 2005.
13. Dai X, Noga BR, Douglas JR, Jordan LM. Localization of spinal neurons activated during locomotion using the c-fos immunohistochemical method. J Neurophysiol 93: 3442-3452, 2005.
14. 1B receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo. J Neurochem 75: 2113-2122, 2000.
15. Daws LC, Montañez S, Owens WA, Gould GG, Frazer A, Toney GM, Gerhardt GA. Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry. J Neurosci Methods 143: 49-62, 2005.
16. Daws LC, Toney GM, Davis DJ, Gerhardt GA, Frazer A. In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus. J Neurosci Methods 78: 139-150, 1997.
17. Daws LC, Toney GM, Gerhardt GA, Frazer A. In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepineprine transporters. J Pharmacol Exp Ther 286: 967-976, 1998.
18. Feraboli-Lohnherr D, Barthe J-V, Orsal D. Serotonin-induced activation of the network for locomotion in adult spinal rats. J Neurosci Res 55: 87-98, 1999.
19. Fong AJ, Cai LL, Otoshi CK, Reinkensmeyer DJ, Burdick JW, Roy RR, Edgerton VR. Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training. J Neurosci 25: 11738-11747, 2005.
20. 3 receptors modulate spinal nociceptive reflexes. Brain Res 510: 12-16, 1990.
21. Hains BC, Johnson KM, McAdoo DJ, Eaton MJ, Hulsebosch CE. Engraftment of serotonergic precursors enhances locomotor function and attenuates chronic central pain behavior following spinal hemisection injury in the rat. Exp Neurol 171: 361-378, 2001.
22. Hentall ID, Mesigil RP, Pinzon A, Noga BR. Temporal and spatial profiles of pontine-evoked monoamine release in the rat's spinal cord. J Neurophysiol 89: 2943-2951, 2003.
23. Hentall ID, Pinzon A, Noga BR. Spatial and temporal patterns of serotonin release in the rat's lumbar spinal cord following electrical stimulation of the nucleus raphe magnus. Neuroscience 142: 893-903, 2006.
24. Hochman S, Garraway S, Machacek D, Shay B. 5-HT receptors and the neuromodulatory control of spinal cord function. In: Methods and New Frontiers in Neuroscience Series: Motor Neurobiology of the Spinal Cord, edited by Cope T. Boca Raton, FL: CRC Press, 2001, p. 47-87.
25. Jackson BP, Wightman RM. Dynamics of 5-hydroxytryptamine released from dopamine neurons in the caudate putamen of the rat. Brain Res 674: 163-166, 1995.
26. Kiehn O, Kjærulff O. Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J Neurophysiol 75: 1472-1482, 1996.
27. Kjærulff O, Kiehn O. Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study. J Neurosci 16: 5777-5794, 1996.
28. Lopez-Garcia JA. Serotonergic modulation of the responses to excitatory amino acids of rat dorsal horn neurons in vitro: implications for somatosensory transmission. Eur J Neurosci 10: 1341-1349, 1998.
29. Madden CJ, Morrison SF. Serotonin potentiates sympathetic responses evoked by spinal NMDA. J Physiol 577: 525-537, 2006.
30. Marinesco S, Poncet L, Debilly G, Jouvet M, Cespuglio R. Effects of tianeptine, sertraline and clomipramine on brain serotonin metabolism: a voltammetric approach in the rat. Brain Res 736: 82-90, 1996.
31. McLone DG, Bondareff W. Developmental morphology of the subarachnoid space and contiguous structures in the mouse. Am J Anat 142: 273-294, 1975.
32. Michael D, Travis ER, Wightman RM. Color images for fast-scan CV measurements in biological systems. Anal Chem News Features 586A-592A, 1998.
33. Montañez S, Daws LC, Gould GG, Frazer A. Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons. J Neurochem 87: 861-867, 2003.
34. Morse DE, Low FN. The fine structure of the pia mater in the rat. Am J Anat 133: 349-368, 1972.
35. Nicholson C, Syková E. Extracellular space structure revealed by diffusion analysis. Trends Neurosci 21: 207-215, 1998.
36. Noga BR, Pinzon A, Ballester B, Ospina D, Hentall ID. Serotonin concentrations in the adult rat spinal cord (SC) measured simultaneously by fast cyclic voltammetry (FCV) at several locations following microinjection or surface application. Soc Neurosci Abstr 31: 749.12, 2005.
37. Noga BR, Pinzon A, Mesigil RP, Hentall ID. Steady-state levels of monoamines in the rat lumbar spinal cord: spatial mapping and the effect of acute spinal cord injury. J Neurophysiol 92: 567-577, 2004.
38. Phillips PEM, Stamford JA. Voltammogram "landscapes" aid detection of in vivo electrochemical signals. Electroanalysis 11: 301-307, 1999.
39. Prokopová S, Vargová L, Syková E. Hetergeneous and anisotropic diffusion in the developing rat spinal cord. Neuroreport 8: 3527-3532, 1997.
40. Reina MA, Casasola ODL, Villanueva MC, López A, Machés F, Andrés JAD. Ultrastructural findings in human spinal pia mater in relation to subarachnoid anesthesia. Anesth Analg 98: 1479-1485, 2004.
41. Rice ME, Okada YC, Nicholson C. Anisotropic and heterogeneous diffusion in the turtle cerebellum: implications for volume transmission. J Neurophysiol 70: 2035-2044, 1993.
42. Schmauss C, Hammond DL, Ochi JW, Yaksh TL. Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord. Eur J Pharmacol 90: 349-357, 1983.
43. Schmidt BJ, Jordan LM. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res Bull 53: 689-710, 2000.
44. Šimonová Z, Svoboda J, Orkand R, Bernard CCA, Lassmann H, Syková E. Changes of extracellular space volume and tortuosity in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis. Physiol Res 45: 11-22, 1996.
45. Stamford JA, Crespi F, Marsden CA. In vivo voltammetric methods for monitoring amine release and metabolism. In: Monitoring Neuronal Activity, edited by Stamford JA. New York: Oxford Univ. Press, 1992, p. 113-145.
46. Sur C, Betz H, Schloss P. Localization of the serotonin transporter in rat spinal cord. Eur J Neurosci 8: 2753-2757, 1996.
47. Syková E. Extrasynaptic volume transmission and diffusion parameters of the extracellular space. Neuroscience 129: 861-876, 2004.
48. Syková E, Chvátal A. Extracellular ionic and volume changes: the role in glia-neuron interaction. J Chem Neuroanat 6: 247-260, 1993.
49. Syková E, Mazel T, Vargová L, Voøíš ek I, Prokopová-Kubinová S. Extracellular space diffusion and pathological states. Prog Brain Res 125: 155-178, 2000.
50. Syková E, Svoboda J, Polák J, Chvátal A. Extracellular volume fraction and diffusion characteristics during progressive ischemia and terminal anoxia in the spinal cord of the rat. J Cereb Blood Flow Metab 14: 301-311, 1994.
51. Willis WD, Westlund KN. Neuroanatomy of the pain system and of the pathways that modulate pain. J Clin Neurophysiol 14: 2-31, 1997.
52. Xu W, Qiu XC, Han JS. Serotonin receptor subtypes in spinal antinociception in the rat. J Pharmacol Exp Ther 269: 1182-1189, 1994.
53. Zahniser NR, Dickinson SD, Gerhardt GA. High-speed chronoamperometric electrochemical measurements of dopamine clearance. Methods Enzymol 296: 708-719, 1998.
54. Zhou FC, Lesch K-P, Murphy D. Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res 942: 109-119, 2002.